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Research ArticleClinical Studies

Whole-liver Palliative Radiotherapy Using SIB for Diffuse Liver Metastases: 3D-CRT versus 99mTc-GSA SPECT Image-guided VMAT

YOSHINOBU SHIMOHIGASHI, RYO TOYA, YUDAI KAI, YASUHIRO DOI, SHINYA SHIRAISHI, MASATO MARUYAMA, YOSHIFUMI MATSUSHIMA, JUN NAKAGAWA, TAKAAKI NAKAMURA, TOSHINORI HIRAI and NATSUO OYA
Anticancer Research April 2026, 46 (4) 2277-2284; DOI: https://doi.org/10.21873/anticanres.18115
YOSHINOBU SHIMOHIGASHI
1Department of Radiological Technology, Kumamoto University Hospital, Kumamoto, Japan;
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RYO TOYA
2Department of Radiological Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan;
3Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan;
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  • For correspondence: toya{at}nagasaki-u.ac.jp
YUDAI KAI
1Department of Radiological Technology, Kumamoto University Hospital, Kumamoto, Japan;
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YASUHIRO DOI
1Department of Radiological Technology, Kumamoto University Hospital, Kumamoto, Japan;
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SHINYA SHIRAISHI
4Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
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MASATO MARUYAMA
1Department of Radiological Technology, Kumamoto University Hospital, Kumamoto, Japan;
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YOSHIFUMI MATSUSHIMA
2Department of Radiological Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan;
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JUN NAKAGAWA
2Department of Radiological Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan;
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TAKAAKI NAKAMURA
2Department of Radiological Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan;
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TOSHINORI HIRAI
4Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
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NATSUO OYA
3Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan;
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Article Information

vol. 46 no. 4 2277-2284
DOI 
https://doi.org/10.21873/anticanres.18115
PMID 
41895767

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received January 29, 2026
  • Revision received February 22, 2026
  • Accepted February 24, 2026
  • Published online March 27, 2026.

Copyright & Usage 
Copyright © 2026 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. YOSHINOBU SHIMOHIGASHI1,
  2. RYO TOYA2,3⇑,
  3. YUDAI KAI1,
  4. YASUHIRO DOI1,
  5. SHINYA SHIRAISHI4,
  6. MASATO MARUYAMA1,
  7. YOSHIFUMI MATSUSHIMA2,
  8. JUN NAKAGAWA2,
  9. TAKAAKI NAKAMURA2,
  10. TOSHINORI HIRAI4 and
  11. NATSUO OYA3
  1. 1Department of Radiological Technology, Kumamoto University Hospital, Kumamoto, Japan;
  2. 2Department of Radiological Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan;
  3. 3Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan;
  4. 4Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
  1. Ryo Toya, Department of Radiological Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. Tel: +81 958197354, Fax: +81 958197357, e-mail: toya{at}nagasaki-u.ac.jp
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Anticancer Research: 46 (4)
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Whole-liver Palliative Radiotherapy Using SIB for Diffuse Liver Metastases: 3D-CRT versus 99mTc-GSA SPECT Image-guided VMAT
YOSHINOBU SHIMOHIGASHI, RYO TOYA, YUDAI KAI, YASUHIRO DOI, SHINYA SHIRAISHI, MASATO MARUYAMA, YOSHIFUMI MATSUSHIMA, JUN NAKAGAWA, TAKAAKI NAKAMURA, TOSHINORI HIRAI, NATSUO OYA
Anticancer Research Apr 2026, 46 (4) 2277-2284; DOI: 10.21873/anticanres.18115

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Whole-liver Palliative Radiotherapy Using SIB for Diffuse Liver Metastases: 3D-CRT versus 99mTc-GSA SPECT Image-guided VMAT
YOSHINOBU SHIMOHIGASHI, RYO TOYA, YUDAI KAI, YASUHIRO DOI, SHINYA SHIRAISHI, MASATO MARUYAMA, YOSHIFUMI MATSUSHIMA, JUN NAKAGAWA, TAKAAKI NAKAMURA, TOSHINORI HIRAI, NATSUO OYA
Anticancer Research Apr 2026, 46 (4) 2277-2284; DOI: 10.21873/anticanres.18115
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Keywords

  • Diffuse liver metastases
  • whole-liver radiotherapy
  • 99mTc-labeled diethylenetriamine pentaacetate-galactosyl human serum albumin
  • single-photon emission computed tomography
  • inverse planning
  • volumetric modulated arc therapy
  • simultaneous integrated boost
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