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Research ArticleExperimental Studies

Methoxy and Ketone Substitutions of Resveratrol Enhance Its Anticancer Activity by Increasing MEK and ERK Binding Affinity in Colorectal Cancer Cells

PATTHARAPORN SAELIM, ZIN ZIN EI, SATAPAT RACHA, MASASHI YOKOYA, RIKAKO YAMASHITA, PREEDAKORN CHUNHACHA and PITHI CHANVORACHOTE
Anticancer Research April 2026, 46 (4) 1957-1966; DOI: https://doi.org/10.21873/anticanres.18087
PATTHARAPORN SAELIM
1Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
2Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
3College of Interdisciplinary and Integrative Studies,, Graduate School, Chulalongkorn University, Bangkok, Thailand;
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ZIN ZIN EI
1Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
2Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
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SATAPAT RACHA
1Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
2Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
3College of Interdisciplinary and Integrative Studies,, Graduate School, Chulalongkorn University, Bangkok, Thailand;
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MASASHI YOKOYA
4Department of Pharmaceutical Chemistry, Meiji Pharmaceutical University, Tokyo, Japan;
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RIKAKO YAMASHITA
4Department of Pharmaceutical Chemistry, Meiji Pharmaceutical University, Tokyo, Japan;
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PREEDAKORN CHUNHACHA
2Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
5Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
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PITHI CHANVORACHOTE
1Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
2Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
6Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand;
7Sustainable Environment Research Institute, Chulalongkorn University, Bangkok, Thailand
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  • For correspondence: pithi.c{at}chula.ac.th
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Article Information

vol. 46 no. 4 1957-1966
DOI 
https://doi.org/10.21873/anticanres.18087
PMID 
41895748

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received November 13, 2025
  • Revision received December 16, 2025
  • Accepted December 29, 2025
  • Published online March 27, 2026.

Copyright & Usage 
Copyright © 2026 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. PATTHARAPORN SAELIM1,2,3,
  2. ZIN ZIN EI1,2,
  3. SATAPAT RACHA1,2,3,
  4. MASASHI YOKOYA4,
  5. RIKAKO YAMASHITA4,
  6. PREEDAKORN CHUNHACHA2,5 and
  7. PITHI CHANVORACHOTE1,2,6,7⇑
  1. 1Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
  2. 2Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
  3. 3College of Interdisciplinary and Integrative Studies,, Graduate School, Chulalongkorn University, Bangkok, Thailand;
  4. 4Department of Pharmaceutical Chemistry, Meiji Pharmaceutical University, Tokyo, Japan;
  5. 5Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;
  6. 6Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand;
  7. 7Sustainable Environment Research Institute, Chulalongkorn University, Bangkok, Thailand
  1. Pithi Chanvorachote, 254 Phaya Thai Rd, Wang Mai, Pathum Wan, Bangkok 10330, Thailand. Tel: +66 22188344, e-mail: pithi.c{at}chula.ac.th
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Methoxy and Ketone Substitutions of Resveratrol Enhance Its Anticancer Activity by Increasing MEK and ERK Binding Affinity in Colorectal Cancer Cells
PATTHARAPORN SAELIM, ZIN ZIN EI, SATAPAT RACHA, MASASHI YOKOYA, RIKAKO YAMASHITA, PREEDAKORN CHUNHACHA, PITHI CHANVORACHOTE
Anticancer Research Apr 2026, 46 (4) 1957-1966; DOI: 10.21873/anticanres.18087

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Methoxy and Ketone Substitutions of Resveratrol Enhance Its Anticancer Activity by Increasing MEK and ERK Binding Affinity in Colorectal Cancer Cells
PATTHARAPORN SAELIM, ZIN ZIN EI, SATAPAT RACHA, MASASHI YOKOYA, RIKAKO YAMASHITA, PREEDAKORN CHUNHACHA, PITHI CHANVORACHOTE
Anticancer Research Apr 2026, 46 (4) 1957-1966; DOI: 10.21873/anticanres.18087
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Keywords

  • Resveratrol
  • SM-23
  • colorectal cancer
  • MEK
  • ERK
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