Methoxy and Ketone Substitutions of Resveratrol Enhance Its Anticancer Activity by Increasing MEK and ERK Binding Affinity in Colorectal Cancer Cells

PATTHARAPORN SAELIM; ZIN ZIN EI; SATAPAT RACHA; MASASHI YOKOYA; RIKAKO YAMASHITA; PREEDAKORN CHUNHACHA; PITHI CHANVORACHOTE

doi:10.21873/anticanres.18087

Research ArticleExperimental Studies

Methoxy and Ketone Substitutions of Resveratrol Enhance Its Anticancer Activity by Increasing MEK and ERK Binding Affinity in Colorectal Cancer Cells

PATTHARAPORN SAELIM, ZIN ZIN EI, SATAPAT RACHA, MASASHI YOKOYA, RIKAKO YAMASHITA, PREEDAKORN CHUNHACHA and PITHI CHANVORACHOTE

Anticancer Research April 2026, 46 (4) 1957-1966; DOI: https://doi.org/10.21873/anticanres.18087

PATTHARAPORN SAELIM

1Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;

2Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;

3College of Interdisciplinary and Integrative Studies,, Graduate School, Chulalongkorn University, Bangkok, Thailand;

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ZIN ZIN EI

1Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;

2Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;

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SATAPAT RACHA

1Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;

2Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;

3College of Interdisciplinary and Integrative Studies,, Graduate School, Chulalongkorn University, Bangkok, Thailand;

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MASASHI YOKOYA

4Department of Pharmaceutical Chemistry, Meiji Pharmaceutical University, Tokyo, Japan;

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RIKAKO YAMASHITA

4Department of Pharmaceutical Chemistry, Meiji Pharmaceutical University, Tokyo, Japan;

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PREEDAKORN CHUNHACHA

2Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;

5Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;

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PITHI CHANVORACHOTE

1Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;

2Center of Excellence in Cancer Cell and Molecular Biology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand;

6Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand;

7Sustainable Environment Research Institute, Chulalongkorn University, Bangkok, Thailand

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For correspondence: pithi.c{at}chula.ac.th

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Methoxy and Ketone Substitutions of Resveratrol Enhance Its Anticancer Activity by Increasing MEK and ERK Binding Affinity in Colorectal Cancer Cells

PATTHARAPORN SAELIM, ZIN ZIN EI, SATAPAT RACHA, MASASHI YOKOYA, RIKAKO YAMASHITA, PREEDAKORN CHUNHACHA, PITHI CHANVORACHOTE

Anticancer Research Apr 2026, 46 (4) 1957-1966; DOI: 10.21873/anticanres.18087

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Methoxy and Ketone Substitutions of Resveratrol Enhance Its Anticancer Activity by Increasing MEK and ERK Binding Affinity in Colorectal Cancer Cells

PATTHARAPORN SAELIM, ZIN ZIN EI, SATAPAT RACHA, MASASHI YOKOYA, RIKAKO YAMASHITA, PREEDAKORN CHUNHACHA, PITHI CHANVORACHOTE

Anticancer Research Apr 2026, 46 (4) 1957-1966; DOI: 10.21873/anticanres.18087

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Keywords

Resveratrol
SM-23
colorectal cancer
MEK
ERK

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