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Research ArticleExperimental Studies

Paired-sample Analysis of ERG Expression and TMPRSS2–ERG Fusion in Treatment-induced Neuroendocrine Prostate Cancer

RYUTA WATANABE, RYU SHIGEHISA, TATSUSHI KAWADA, SHINKURO YAMAMOTO, SATOSHI KATAYAMA, ATSUSHI TAKAMOTO, KENICHI NISHIMURA, NORIYOSHI MIURA, MOTOO ARAKI, KEIJI INOUE and TAKASHI SAIKA; on behalf of Chu-shikoku Japan Urological Consortium (CsJUC) Research Collaboration
Anticancer Research April 2026, 46 (4) 1929-1942; DOI: https://doi.org/10.21873/anticanres.18085
RYUTA WATANABE
1Department of Urology, Ehime University Graduate School of Medicine, Toon, Japan;
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  • For correspondence: watanabe.ryuta.cu{at}ehime-u.ac.jp
RYU SHIGEHISA
2Department of Urology, Kochi Medical School, Kochi University, Nankoku, Japan;
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TATSUSHI KAWADA
3Department of Urology, Okayama University Graduate School of Medicine, Okayama, Japan;
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SHINKURO YAMAMOTO
2Department of Urology, Kochi Medical School, Kochi University, Nankoku, Japan;
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SATOSHI KATAYAMA
3Department of Urology, Okayama University Graduate School of Medicine, Okayama, Japan;
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ATSUSHI TAKAMOTO
4Department of Urology, Fukuyama City Hospital, Fukuyama, Japan
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KENICHI NISHIMURA
1Department of Urology, Ehime University Graduate School of Medicine, Toon, Japan;
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NORIYOSHI MIURA
1Department of Urology, Ehime University Graduate School of Medicine, Toon, Japan;
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MOTOO ARAKI
3Department of Urology, Okayama University Graduate School of Medicine, Okayama, Japan;
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KEIJI INOUE
2Department of Urology, Kochi Medical School, Kochi University, Nankoku, Japan;
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TAKASHI SAIKA
1Department of Urology, Ehime University Graduate School of Medicine, Toon, Japan;
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Article Information

vol. 46 no. 4 1929-1942
DOI 
https://doi.org/10.21873/anticanres.18085
PMID 
41895744

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received December 28, 2025
  • Revision received January 20, 2026
  • Accepted February 4, 2026
  • Published online March 27, 2026.

Copyright & Usage 
Copyright © 2026 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. RYUTA WATANABE1⇑,
  2. RYU SHIGEHISA2,
  3. TATSUSHI KAWADA3,
  4. SHINKURO YAMAMOTO2,
  5. SATOSHI KATAYAMA3,
  6. ATSUSHI TAKAMOTO4,
  7. KENICHI NISHIMURA1,
  8. NORIYOSHI MIURA1,
  9. MOTOO ARAKI3,
  10. KEIJI INOUE2 and
  11. TAKASHI SAIKA1
  12. on behalf of Chu-shikoku Japan Urological Consortium (CsJUC) Research Collaboration
  1. 1Department of Urology, Ehime University Graduate School of Medicine, Toon, Japan;
  2. 2Department of Urology, Kochi Medical School, Kochi University, Nankoku, Japan;
  3. 3Department of Urology, Okayama University Graduate School of Medicine, Okayama, Japan;
  4. 4Department of Urology, Fukuyama City Hospital, Fukuyama, Japan
  1. Ryuta Watanabe, MD, PhD, Department of Urology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, 7910295, Japan. Tel: +81 899605356, Fax: +81 899605358, e-mail: watanabe.ryuta.cu{at}ehime-u.ac.jp
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Anticancer Research: 46 (4)
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Paired-sample Analysis of ERG Expression and TMPRSS2–ERG Fusion in Treatment-induced Neuroendocrine Prostate Cancer
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Paired-sample Analysis of ERG Expression and TMPRSS2–ERG Fusion in Treatment-induced Neuroendocrine Prostate Cancer
RYUTA WATANABE, RYU SHIGEHISA, TATSUSHI KAWADA, SHINKURO YAMAMOTO, SATOSHI KATAYAMA, ATSUSHI TAKAMOTO, KENICHI NISHIMURA, NORIYOSHI MIURA, MOTOO ARAKI, KEIJI INOUE, TAKASHI SAIKA
Anticancer Research Apr 2026, 46 (4) 1929-1942; DOI: 10.21873/anticanres.18085

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Paired-sample Analysis of ERG Expression and TMPRSS2–ERG Fusion in Treatment-induced Neuroendocrine Prostate Cancer
RYUTA WATANABE, RYU SHIGEHISA, TATSUSHI KAWADA, SHINKURO YAMAMOTO, SATOSHI KATAYAMA, ATSUSHI TAKAMOTO, KENICHI NISHIMURA, NORIYOSHI MIURA, MOTOO ARAKI, KEIJI INOUE, TAKASHI SAIKA
Anticancer Research Apr 2026, 46 (4) 1929-1942; DOI: 10.21873/anticanres.18085
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Keywords

  • AR-pathway positive prostate cancers (ARPC)
  • treatment induced NEPC (t-NEPC)
  • ERG expression
  • TMPRSS2-ERG fusion gene
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