P53-armed Oncolytic Adenovirus Enhances the Efficacy of PD-1 Blockade in Neuroblastoma by Inducing Immunogenic Cell Death

MORIMICHI TANI; HIROSHI TAZAWA; TERUTAKA TANIMOTO; HIROSHI NOUSO; HINAKO WATANABE; TAKANORI OYAMA; YASUO URATA; SHUNSUKE KAGAWA; TAKUO NODA; SHINJI KURODA; TOSHIYOSHI FUJIWARA

doi:10.21873/anticanres.18073

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P53-armed Oncolytic Adenovirus Enhances the Efficacy of PD-1 Blockade in Neuroblastoma by Inducing Immunogenic Cell Death

MORIMICHI TANI, HIROSHI TAZAWA, TERUTAKA TANIMOTO, HIROSHI NOUSO, HINAKO WATANABE, TAKANORI OYAMA, YASUO URATA, SHUNSUKE KAGAWA, TAKUO NODA, SHINJI KURODA and TOSHIYOSHI FUJIWARA

Anticancer Research April 2026, 46 (4) 1769-1784; DOI: https://doi.org/10.21873/anticanres.18073

MORIMICHI TANI

1Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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HIROSHI TAZAWA

2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

3Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan;

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For correspondence: htazawa{at}md.okayama-u.ac.jp

TERUTAKA TANIMOTO

1Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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HIROSHI NOUSO

1Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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HINAKO WATANABE

1Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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TAKANORI OYAMA

1Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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YASUO URATA

4Oncolys BioPharma, Inc., Tokyo, Japan

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SHUNSUKE KAGAWA

2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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TAKUO NODA

1Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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SHINJI KURODA

2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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TOSHIYOSHI FUJIWARA

2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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P53-armed Oncolytic Adenovirus Enhances the Efficacy of PD-1 Blockade in Neuroblastoma by Inducing Immunogenic Cell Death

MORIMICHI TANI, HIROSHI TAZAWA, TERUTAKA TANIMOTO, HIROSHI NOUSO, HINAKO WATANABE, TAKANORI OYAMA, YASUO URATA, SHUNSUKE KAGAWA, TAKUO NODA, SHINJI KURODA, TOSHIYOSHI FUJIWARA

Anticancer Research Apr 2026, 46 (4) 1769-1784; DOI: 10.21873/anticanres.18073

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P53-armed Oncolytic Adenovirus Enhances the Efficacy of PD-1 Blockade in Neuroblastoma by Inducing Immunogenic Cell Death

MORIMICHI TANI, HIROSHI TAZAWA, TERUTAKA TANIMOTO, HIROSHI NOUSO, HINAKO WATANABE, TAKANORI OYAMA, YASUO URATA, SHUNSUKE KAGAWA, TAKUO NODA, SHINJI KURODA, TOSHIYOSHI FUJIWARA

Anticancer Research Apr 2026, 46 (4) 1769-1784; DOI: 10.21873/anticanres.18073

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Keywords

Neuroblastoma
oncolytic adenovirus
p53
immunogenic cell death
PD-1

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