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Research ArticleClinical Studies

Immature Peritumoral Tertiary Lymphoid Structures Indicate Poor Prognosis in Pancreatic Ductal Adenocarcinoma After NAC

MARI NABEYA, MASAO NAKAJIMA, RYOUICHI TSUNEDOMI, TAKAHIRO OZASA, YUTA KIMURA, HIROTO MATSUI, YUKIO TOKUMITSU, YOSHITARO SHINDO, MICHIHISA IIDA, YUKI NAKAGAMI, YOSHINOBU HOSHII, TATSUYA IOKA, HIDENORI TAKAHASHI and HIROAKI NAGANO
Anticancer Research March 2026, 46 (3) 1661-1676; DOI: https://doi.org/10.21873/anticanres.18061
MARI NABEYA
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
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MASAO NAKAJIMA
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
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RYOUICHI TSUNEDOMI
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
2Research Institute for Cell Design Medical Science, Yamaguchi University, Ube, Japan;
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  • For correspondence: tsune-r{at}yamaguchi-u.ac.jp
TAKAHIRO OZASA
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
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YUTA KIMURA
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
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HIROTO MATSUI
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
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YUKIO TOKUMITSU
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
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YOSHITARO SHINDO
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
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MICHIHISA IIDA
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
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YUKI NAKAGAMI
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
3Health Data Science Laboratory, Faculty of Data Science, Shimonoseki City University, Shimonoseki, Japan;
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YOSHINOBU HOSHII
4Department of Diagnostic Pathology, Yamaguchi University Hospital, Ube, Japan;
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TATSUYA IOKA
5Oncology Center, Yamaguchi University Hospital, Ube, Japan
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HIDENORI TAKAHASHI
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
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HIROAKI NAGANO
1 Department of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan;
2Research Institute for Cell Design Medical Science, Yamaguchi University, Ube, Japan;
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Anticancer Research: 46 (3)
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March 2026
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Immature Peritumoral Tertiary Lymphoid Structures Indicate Poor Prognosis in Pancreatic Ductal Adenocarcinoma After NAC
MARI NABEYA, MASAO NAKAJIMA, RYOUICHI TSUNEDOMI, TAKAHIRO OZASA, YUTA KIMURA, HIROTO MATSUI, YUKIO TOKUMITSU, YOSHITARO SHINDO, MICHIHISA IIDA, YUKI NAKAGAMI, YOSHINOBU HOSHII, TATSUYA IOKA, HIDENORI TAKAHASHI, HIROAKI NAGANO
Anticancer Research Mar 2026, 46 (3) 1661-1676; DOI: 10.21873/anticanres.18061

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Immature Peritumoral Tertiary Lymphoid Structures Indicate Poor Prognosis in Pancreatic Ductal Adenocarcinoma After NAC
MARI NABEYA, MASAO NAKAJIMA, RYOUICHI TSUNEDOMI, TAKAHIRO OZASA, YUTA KIMURA, HIROTO MATSUI, YUKIO TOKUMITSU, YOSHITARO SHINDO, MICHIHISA IIDA, YUKI NAKAGAMI, YOSHINOBU HOSHII, TATSUYA IOKA, HIDENORI TAKAHASHI, HIROAKI NAGANO
Anticancer Research Mar 2026, 46 (3) 1661-1676; DOI: 10.21873/anticanres.18061
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Keywords

  • Pancreatic ductal adenocarcinoma
  • tertiary lymphoid structure
  • neoadjuvant chemotherapy
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