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Research ArticleExperimental Studies

The Privileged Scaffold Quinoline in Derivatives With Anticancer Potential Mediated by Late Apoptosis

DENISE DIEDRICH, ELENILSON F. SILVA, JULIA B. WILLIG, THAÍS C. RUARO, NÁDIA M.G. COUTO, MICKAEL JEAN, GLORIA N.S. SILVA, DIOGO A. PILGER, ALINE R. ZIMMER, PIERRE V. WEGUE and SIMONE C.B. GNOATTO
Anticancer Research March 2026, 46 (3) 1475-1487; DOI: https://doi.org/10.21873/anticanres.18042
DENISE DIEDRICH
1Laboratory of Phytochemistry and Organic Synthesis, Department of Raw Material Production, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;
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ELENILSON F. SILVA
1Laboratory of Phytochemistry and Organic Synthesis, Department of Raw Material Production, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;
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JULIA B. WILLIG
2Laboratory of Biochemical and Cytological Analysis, Postgraduate Program in Pharmaceutical Sciences, School of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;
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THAÍS C. RUARO
1Laboratory of Phytochemistry and Organic Synthesis, Department of Raw Material Production, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;
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NÁDIA M.G. COUTO
1Laboratory of Phytochemistry and Organic Synthesis, Department of Raw Material Production, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;
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MICKAEL JEAN
3Natural Products Syntheses and Medicinal Chemistry Laboratory, Rennes University 1, Rennes, France;
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GLORIA N.S. SILVA
4School of Pharmacy, Federal University of Bahia, Salvador, Brazil
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  • For correspondence: gloriasilva{at}ufba.br
DIOGO A. PILGER
2Laboratory of Biochemical and Cytological Analysis, Postgraduate Program in Pharmaceutical Sciences, School of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;
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ALINE R. ZIMMER
1Laboratory of Phytochemistry and Organic Synthesis, Department of Raw Material Production, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;
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PIERRE V. WEGUE
3Natural Products Syntheses and Medicinal Chemistry Laboratory, Rennes University 1, Rennes, France;
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SIMONE C.B. GNOATTO
1Laboratory of Phytochemistry and Organic Synthesis, Department of Raw Material Production, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;
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Article Information

vol. 46 no. 3 1475-1487
DOI 
https://doi.org/10.21873/anticanres.18042
PMID 
41760281

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received December 7, 2025
  • Revision received December 29, 2025
  • Accepted January 7, 2026
  • Published online February 27, 2026.

Copyright & Usage 
Copyright © 2026 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. DENISE DIEDRICH1,
  2. ELENILSON F. SILVA1,
  3. JULIA B. WILLIG2,
  4. THAÍS C. RUARO1,
  5. NÁDIA M.G. COUTO1,
  6. MICKAEL JEAN3,
  7. GLORIA N.S. SILVA4⇑,
  8. DIOGO A. PILGER2,
  9. ALINE R. ZIMMER1,
  10. PIERRE V. WEGUE3 and
  11. SIMONE C.B. GNOATTO1
  1. 1Laboratory of Phytochemistry and Organic Synthesis, Department of Raw Material Production, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;
  2. 2Laboratory of Biochemical and Cytological Analysis, Postgraduate Program in Pharmaceutical Sciences, School of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, Brazil;
  3. 3Natural Products Syntheses and Medicinal Chemistry Laboratory, Rennes University 1, Rennes, France;
  4. 4School of Pharmacy, Federal University of Bahia, Salvador, Brazil
  1. Gloria Narjara Santos da Silva, School of Pharmacy, Federal University of Bahia, Campus Ondina, Salvador, BA, Brazil. E-mail: gloriasilva{at}ufba.br
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The Privileged Scaffold Quinoline in Derivatives With Anticancer Potential Mediated by Late Apoptosis
DENISE DIEDRICH, ELENILSON F. SILVA, JULIA B. WILLIG, THAÍS C. RUARO, NÁDIA M.G. COUTO, MICKAEL JEAN, GLORIA N.S. SILVA, DIOGO A. PILGER, ALINE R. ZIMMER, PIERRE V. WEGUE, SIMONE C.B. GNOATTO
Anticancer Research Mar 2026, 46 (3) 1475-1487; DOI: 10.21873/anticanres.18042

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The Privileged Scaffold Quinoline in Derivatives With Anticancer Potential Mediated by Late Apoptosis
DENISE DIEDRICH, ELENILSON F. SILVA, JULIA B. WILLIG, THAÍS C. RUARO, NÁDIA M.G. COUTO, MICKAEL JEAN, GLORIA N.S. SILVA, DIOGO A. PILGER, ALINE R. ZIMMER, PIERRE V. WEGUE, SIMONE C.B. GNOATTO
Anticancer Research Mar 2026, 46 (3) 1475-1487; DOI: 10.21873/anticanres.18042
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Keywords

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