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Research ArticleExperimental Studies

Concurrent Pemetrexed With EGFR-TKI Slows the Accumulation of De Novo Mutations During In Vitro Exposure

ESHAT F. HAQUE, RYOSUKE TANINO, TAMIO OKIMOTO, TAKAMASA HOTTA, TAKAE OKUNO, KENTO KONO, YUKARI TSUBATA and TAKESHI ISOBE
Anticancer Research March 2026, 46 (3) 1323-1335; DOI: https://doi.org/10.21873/anticanres.18032
ESHAT F. HAQUE
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Izumo, Japan
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RYOSUKE TANINO
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Izumo, Japan
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TAMIO OKIMOTO
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Izumo, Japan
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  • For correspondence: okimoto{at}med.shimane-u.ac.jp
TAKAMASA HOTTA
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Izumo, Japan
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TAKAE OKUNO
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Izumo, Japan
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KENTO KONO
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Izumo, Japan
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YUKARI TSUBATA
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Izumo, Japan
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TAKESHI ISOBE
Department of Internal Medicine, Division of Medical Oncology & Respiratory Medicine, Shimane University Faculty of Medicine, Izumo, Japan
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Article Information

vol. 46 no. 3 1323-1335
DOI 
https://doi.org/10.21873/anticanres.18032
PMID 
41760274

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received November 21, 2025
  • Revision received December 12, 2025
  • Accepted December 23, 2025
  • Published online February 27, 2026.

Copyright & Usage 
Copyright © 2026 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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Anticancer Research: 46 (3)
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Concurrent Pemetrexed With EGFR-TKI Slows the Accumulation of De Novo Mutations During In Vitro Exposure
ESHAT F. HAQUE, RYOSUKE TANINO, TAMIO OKIMOTO, TAKAMASA HOTTA, TAKAE OKUNO, KENTO KONO, YUKARI TSUBATA, TAKESHI ISOBE
Anticancer Research Mar 2026, 46 (3) 1323-1335; DOI: 10.21873/anticanres.18032

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Concurrent Pemetrexed With EGFR-TKI Slows the Accumulation of De Novo Mutations During In Vitro Exposure
ESHAT F. HAQUE, RYOSUKE TANINO, TAMIO OKIMOTO, TAKAMASA HOTTA, TAKAE OKUNO, KENTO KONO, YUKARI TSUBATA, TAKESHI ISOBE
Anticancer Research Mar 2026, 46 (3) 1323-1335; DOI: 10.21873/anticanres.18032
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Keywords

  • Concurrent therapy
  • EGFR-TKI
  • pemetrexed
  • tumor mutational burden
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