Lack of Cancer Specificity of Methionine Adenosyltransferase 2A (MAT2A) Inhibitor AG-270 in Combination With Recombinant Methioninase In Vitro

JINSOO KIM; QINGHONG HAN; SHUKUAN LI; BYUNG MO KANG; KOHEI MIZUTA; YOHEI ASANO; YUTA MIYASHI; MICHAEL BOUVET; ROBERT M. HOFFMAN

doi:10.21873/anticanres.17980

Research ArticleExperimental Studies

Lack of Cancer Specificity of Methionine Adenosyltransferase 2A (MAT2A) Inhibitor AG-270 in Combination With Recombinant Methioninase In Vitro

JINSOO KIM, QINGHONG HAN, SHUKUAN LI, BYUNG MO KANG, KOHEI MIZUTA, YOHEI ASANO, YUTA MIYASHI, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research February 2026, 46 (2) 705-712; DOI: https://doi.org/10.21873/anticanres.17980

JINSOO KIM

1AntiCancer Inc., San Diego, CA, U.S.A.;

2Department of Surgery, University of California, San Diego, CA, U.S.A.;

3Department of Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea

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QINGHONG HAN

1AntiCancer Inc., San Diego, CA, U.S.A.;

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SHUKUAN LI

1AntiCancer Inc., San Diego, CA, U.S.A.;

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BYUNG MO KANG

1AntiCancer Inc., San Diego, CA, U.S.A.;

2Department of Surgery, University of California, San Diego, CA, U.S.A.;

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KOHEI MIZUTA

1AntiCancer Inc., San Diego, CA, U.S.A.;

2Department of Surgery, University of California, San Diego, CA, U.S.A.;

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YOHEI ASANO

1AntiCancer Inc., San Diego, CA, U.S.A.;

2Department of Surgery, University of California, San Diego, CA, U.S.A.;

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YUTA MIYASHI

1AntiCancer Inc., San Diego, CA, U.S.A.;

2Department of Surgery, University of California, San Diego, CA, U.S.A.;

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MICHAEL BOUVET

2Department of Surgery, University of California, San Diego, CA, U.S.A.;

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ROBERT M. HOFFMAN

1AntiCancer Inc., San Diego, CA, U.S.A.;

2Department of Surgery, University of California, San Diego, CA, U.S.A.;

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For correspondence: all{at}anticancer.com

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Lack of Cancer Specificity of Methionine Adenosyltransferase 2A (MAT2A) Inhibitor AG-270 in Combination With Recombinant Methioninase In Vitro

JINSOO KIM, QINGHONG HAN, SHUKUAN LI, BYUNG MO KANG, KOHEI MIZUTA, YOHEI ASANO, YUTA MIYASHI, MICHAEL BOUVET, ROBERT M. HOFFMAN

Anticancer Research Feb 2026, 46 (2) 705-712; DOI: 10.21873/anticanres.17980

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Lack of Cancer Specificity of Methionine Adenosyltransferase 2A (MAT2A) Inhibitor AG-270 in Combination With Recombinant Methioninase In Vitro

JINSOO KIM, QINGHONG HAN, SHUKUAN LI, BYUNG MO KANG, KOHEI MIZUTA, YOHEI ASANO, YUTA MIYASHI, MICHAEL BOUVET, ROBERT M. HOFFMAN

Anticancer Research Feb 2026, 46 (2) 705-712; DOI: 10.21873/anticanres.17980

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Keywords

MAT2A
AG-270
recombinant methioninase
combination
synergy
HCT116 colon cancer cells
Hs-27 normal fibroblasts
Methionine addiction
Hoffman effect

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