Table of Contents

Clinical Studies

• Open Access

  Geographic Variations in Demographics, Socioeconomic Status, and Stage at Diagnosis Among Hormone Receptor–positive Invasive Ductal Carcinoma: An NCDB Analysis (2004-2020)

  BERKAY DEMIRORS, SYEDA HOORULAIN AHMED, KAREN GRACE, PAOLA BERRIOS JIMENEZ, JADE C. BOWERS, VISHAL ABHIMUTT MAHESH, ANJALI YADAV, HARSHEEN K. MANAISE, GUIDO CHIRIBOGA, LOLA FUENTES BROCK, REED POPP, ANGEL AGUAYO MERLY and EMMANUEL GABRIEL

  Anticancer Research February 2026, 46 (2) 811-817; DOI: https://doi.org/10.21873/anticanres.17989
• Open Access

  Describing the Mutational Characteristics of Myxofibrosarcoma: An AACR Project GENIE Analysis

  MARLAENA NOONEY, BRYCE RIGDEN, ELIJAH TORBENSON, MARCO BRAATEN, BEAU HSIA, ABRAHAM MATHEWS and ABUBAKAR TAUSEEF

  Anticancer Research February 2026, 46 (2) 819-833; DOI: https://doi.org/10.21873/anticanres.17990
• Open Access

  Polymorphisms of FGFR Pathway-related Factors and Capecitabine-induced Hand-foot Syndrome in Japanese Patients With Colorectal Cancer

  RIKU YAMANAKA, NATSUMI MATSUMOTO, REMI MURASE, YUTARO KUBOTA, HIROO ISHIDA, KEN SHIMADA and KEN-ICHI FUJITA

  Anticancer Research February 2026, 46 (2) 835-846; DOI: https://doi.org/10.21873/anticanres.17991
• Open Access

  Clinical Parameters and Radiomics of Vestibular Schwannomas in NF2-related Schwannomatosis

  NINA BOE, VICTOR-F. MAUTNER, REINHARD E. FRIEDRICH, SAID C. FARSCHTSCHI, LASSE DÜHRSEN, HANNO S. MEYER and JOHANNES A. KOEPPEN

  Anticancer Research February 2026, 46 (2) 847-856; DOI: https://doi.org/10.21873/anticanres.17992
• Open Access

  Prognostic Factors and the Impact of Adjuvant S-1 Chemotherapy in Resected Ampulla of Vater Carcinoma: A Single-institution Retrospective Study

  HAJIME IMAMURA, TOMOHIKO ADACHI, TAKASHI HAMADA, KAZUSHIGE MIGITA, AYAKA SATOH, KOUKI KUROTAKI, SHUN NAKAMURA, SHINICHIRO OGAWA, BAGLAN ASKEYEV, HAJIME MATSUSHIMA, AYAKA KINOSHITA, AKIHIKO SOYAMA and SUSUMU EGUCHI

  Anticancer Research February 2026, 46 (2) 857-867; DOI: https://doi.org/10.21873/anticanres.17993
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  Over-expression of Anillin Actin Binding Protein in Adrenocortical Carcinoma Tissues Is Associated With Poorer Prognosis of Patients

  SHIN-NOSUKE YAMASHITA, YOSHIATSU TANAKA, SHAJEDUL ISLAM, TAKAO KITAGAWA, KAZUHIRO TOKUDA, DURGA PAUDEL, SARITA GIRI, TOHRU OHTA, FUMIYA HARADA, HIROKI NAGAYASU and YASUHIRO KURAMITSU

  Anticancer Research February 2026, 46 (2) 869-875; DOI: https://doi.org/10.21873/anticanres.17994
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  Short- and Long-term Results of Complete Resection and Vascular Reconstruction for Infrahepatic Inferior Vena Cava Leiomyosarcomas: A Retrospective Case Series of 33 Patients

  PRISCILLA NARDI, VALERIO RINALDI, VALERIA IACOUCCI, GRETA D’ONOFRIO, ELENA MARCELLI, MATTIA NICOLIS, KIM MAYBLUM, FEDERICA PETRUCCI, ENRICO COLETTA, ROCCO PASQUA, PIERGASPARE PALUMBO, GIAMPAOLO PREZIOSO, VITO D’ANDREA, JEAN-BAPTISTE RICCO and GIULIO ILLUMINATI

  Anticancer Research February 2026, 46 (2) 877-884; DOI: https://doi.org/10.21873/anticanres.17995
• Open Access

  Anatomical-specific Lymphatic Route Beyond Mesorectal Fascia: Analyses from Female Cadavers and Patients With Rectal Cancer

  DAISUKE KUWATA, HIROSHI SHIMODA, TAKUYA MIURA, TOMOHIRO CHIBA, KENTARO SATO, YUKI SHIROTO, YOSHIYUKI SAKAMOTO, HAJIME MOROHASHI, TAKUJI KAGIYA and KENICHI HAKAMADA

  Anticancer Research February 2026, 46 (2) 885-899; DOI: https://doi.org/10.21873/anticanres.17996
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  Clinicopathological Significance of HER2 Expression Redefined by the HER2-low Concept in Ductal Carcinoma In Situ

  KOJI TAKADA, SHINICHIRO KASHIWAGI, MAYUKO HIRATA, MARIKO NISHIKAWA, CHIKA WATANABE, YUKIE TAUCHI, KANA OGISAWA, MASATSUNE SHIBUTANI, HARUHITO KINOSHITA and TAMAMI MORISAKI

  Anticancer Research February 2026, 46 (2) 901-909; DOI: https://doi.org/10.21873/anticanres.17997
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  Tumor Location Significantly Correlates With PD-L1 Status in Patients With Small Sized Non-small Cell Lung Cancer

  TAKUMA TSUKIOKA, RYU NAKAJIMA, KYUKWANG CHUNG, SATOSHI OKADA, KAZUYA KISHIMOTO and HIROYUKI KOCHI

  Anticancer Research February 2026, 46 (2) 911-916; DOI: https://doi.org/10.21873/anticanres.17998
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  First-Line Afatinib 30 mg Versus 40 mg in Non-small Cell Lung Cancer Patients With Uncommon EGFR Mutations: Real-world Efficacy and Tolerability in Taiwan

  HUI-YANG HUNG, TAI-HUANG LEE, CHENG-HAO CHUANG, MEI-HSUAN LEE, KUAN-LI WU, CHIA-YU KUO, HUNG-LING HUANG, CHUNG-WEN HUANG, YU-CHEN TSAI, JEN-YU HUNG, INN-WEN CHONG and CHIH-JEN YANG

  Anticancer Research February 2026, 46 (2) 917-938; DOI: https://doi.org/10.21873/anticanres.17999
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  Prognostic Impact of Residual T and N Status After Neoadjuvant Therapy in Breast Cancer

  SAE FUJIOKA, SHINICHIRO KASHIWAGI, YUKO KIKUKAWA, CHIKA WATANABE, KOJI TAKADA, YUKIE TAUCHI, KANA OGISAWA, MASATSUNE SHIBUTANI, HARUHITO KINOSHITA, TAMAMI MORISAKI and KEIKO YOSHIMURA

  Anticancer Research February 2026, 46 (2) 939-947; DOI: https://doi.org/10.21873/anticanres.18000
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  Treatment Patterns and Prognostic Factors of Anti-HER2 Therapy in HER2-positive Advanced/Recurrent Gastric Cancer

  NORIKO WADA, YUKINORI KUROKAWA, TSUYOSHI TAKAHASHI, TAKURO SAITO, TAKAOMI HAGI, SHIGETO NAKAI, KOTA MOMOSE, KOTARO YAMASHITA, KOJI TANAKA, TOMOKI MAKINO, HIDETOSHI EGUCHI, YUICHIRO DOKI and TAROH SATOH

  Anticancer Research February 2026, 46 (2) 949-961; DOI: https://doi.org/10.21873/anticanres.18001
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  Clinical Relevance of the CALLY Index in Prognostic Stratification of Intrahepatic Cholangiocarcinoma

  SATOSHI MATSUI, YOSHIYASU KATO, KATSUHISA OHGI, RYO ASHIDA, SHIMPEI OTSUKA, HIDEYUKI DEI, KATSUHIKO UESAKA and TEIICHI SUGIURA

  Anticancer Research February 2026, 46 (2) 963-974; DOI: https://doi.org/10.21873/anticanres.18002
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  First-line FOLFOXIRI-based Chemotherapy for Unresectable Metastatic Colorectal Cancer: Real-world Outcomes, Safety, and Conversion Surgery

  AKIRA INOUE, HIROFUMI OTA, YUSUKE MATSUURA, KOJI MUNAKATA, MASATAKA FUJIWARA, KOSUKE NISHIHARA, RYUTARO WADA, RYOHEI WADA, YU TAKEDA, SAKAE MAEDA and KOU TAKACHI

  Anticancer Research February 2026, 46 (2) 975-985; DOI: https://doi.org/10.21873/anticanres.18003
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  Delayed Initiation of S-1 Adjuvant Chemotherapy Impairs Survival in Patients With Curatively Resected Pancreatic Cancer

  DONGHA LEE, HIROCHIKA TOYAMA, YOSHIHIDE NANNO, HIROYUKI NAKAMURA, TAISUKE OKAWA, TAKUYA MIZUMOTO, JUN ISHIDA, MASAYUKI AKITA, KEISUKE ARAI, TOSHIHIKO YOSHIDA, SHINICHI SO, TSUYOSHI URADE, KENJI FUKUSHIMA, SHOHEI KOMATSU, SADAKI ASARI, HIROAKI YANAGIMOTO, MASAHIRO KIDO and TAKUMI FUKUMOTO

  Anticancer Research February 2026, 46 (2) 987-999; DOI: https://doi.org/10.21873/anticanres.18004
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  Clinicopathologic Predictors of Outcome and Implications for Adjuvant Therapy in Pathologic Stage II Non-small Cell Lung Cancer

  YI-WEN SHEN, TAI-HUANG LEE, HUI-YANG HUNG, YU-WEI LIU, JUI-YING LEE, YU-TING LO, WEI-AN LAI, SHIH-YU KAO, YI-HSIEN LI, CHIA-HUA LIU and CHIH-JEN YANG

  Anticancer Research February 2026, 46 (2) 1001-1020; DOI: https://doi.org/10.21873/anticanres.18005
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  Prognostic Impact of Claudin18.2 and TROP2 Expression in Advanced Gastric Cancer Treated With Nivolumab

  TAKAHITO AWATSU, TORU KADONO, HIROKAZU SHOJI, TOSHIHARU HIROSE, HIDEKAZU HIRANO, NATSUKO OKITA, ATSUO TAKASHIMA, AKIHITO NAGAHARA and KEN KATO

  Anticancer Research February 2026, 46 (2) 1021-1035; DOI: https://doi.org/10.21873/anticanres.18006
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  Radiotherapy Strategies for Stage II Breast Cancer With Lymphovascular Invasion After Mastectomy

  SHUANG GAO, XUEQIAO YU, YANG LI, LINGLING TAO, SAIHAN BAO, SILIANG ZHANG and LIQIU MA

  Anticancer Research February 2026, 46 (2) 1037-1052; DOI: https://doi.org/10.21873/anticanres.18007
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  Early Predictive Factors for Severe Postoperative Complications Following Major Liver and Pancreatic Surgery

  MASAHIRO FUKADA, NORIKI MITSUI, TAKESHI HORAGUCHI, ITARU YASUFUKU, YUTA SATO, JESSE YU TAJIMA, YOSHIHIRO TANAKA and NOBUHISA MATSUHASHI

  Anticancer Research February 2026, 46 (2) 1053-1066; DOI: https://doi.org/10.21873/anticanres.18008
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  Clinical Activity of MET-TKIs in METex14 Skipping NSCLC With Poor Performance Status

  YOH YAMAGUCHI, TATSUYA YOSHIDA, RYOKO INABA HIGASHIYAMA, KEN MASUDA, YUKI SHINNO, YUSUKE OKUMA, YASUSHI GOTO, HIDEHITO HORINOUCHI, NOBORU YAMAMOTO and YUICHIRO OHE

  Anticancer Research February 2026, 46 (2) 1067-1077; DOI: https://doi.org/10.21873/anticanres.18009
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  Neck Dissection and Immune Checkpoint Inhibitor Efficacy in Head and Neck Cancer: A Retrospective Study

  YOH-ICHIRO IWASA, KENTARO HORI, YOH YOKOTA, RYOSUKE KITOH, SHINTARO YAMAZAKI, TAKUYA OKUBO and YUTAKA TAKUMI

  Anticancer Research February 2026, 46 (2) 1079-1087; DOI: https://doi.org/10.21873/anticanres.18010
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  Prognostic Significance of Extrapancreatic Invasion in Pancreatic Cancer: Excellent Outcomes in Patients With Disease Confined Within the Pancreas

  RYO SAITO, HIDETAKE AMEMIYA, WATARU IZUMO, TAISHU OKA, SUGURU MARUYAMA, KOICHI TAKIGUCHI, KATSUTOSHI SHODA, KENSUKE SHIRAISHI, SHINJI FURUYA, YOSHIHIKO KAWAGUCHI, HIROMICHI KAWAIDA and DAISUKE ICHIKAWA

  Anticancer Research February 2026, 46 (2) 1089-1096; DOI: https://doi.org/10.21873/anticanres.18011
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  The Usefulness of the Modified Controlling Nutritional Status Score for Assessing Prognosis in Patients With Colorectal Cancer

  HIDEKI TANDA, MASATSUNE SHIBUTANI, YUKI SEKI, TSUYOSHI NISHIYAMA, HIROAKI KASASHIMA, TATSUNARI FUKUOKA and KIYOSHI MAEDA

  Anticancer Research February 2026, 46 (2) 1097-1105; DOI: https://doi.org/10.21873/anticanres.18012
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  Prolonged Castration Prior to Docetaxel Reduces Febrile Neutropenia in Patients With Metastatic Hormone-sensitive Prostate Cancer Receiving Triple Therapy

  YASUTAKA YAMADA, TOMOKI SHIRAFUJI, KODAI SATO, TAKUYA TSUJINO, SATOSHI YAMAMOTO, TAKAYUKI ARAI, HIROAKI SATO, KOSUKE HIGUCHI, MANATO KANESAKA, NOBUSHIGE TAKESHITA, TAKAAKI TAMURA, TOMOKAZU SAZUKA, YUSUKE IMAMURA, KAZUO MIKAMI, KAZUYOSHI NAKAMURA, SATOSHI FUKASAWA, AKIRA KUROZUMI, NORIYUKI SUZUKI, HARUHITO AZUMA and SHINICHI SAKAMOTO

  Anticancer Research February 2026, 46 (2) 1107-1116; DOI: https://doi.org/10.21873/anticanres.18013
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  Impact of the Immunonutritional Status on the Feasibility of Subsequent Treatment After the Discontinuation of Trifluridine-Tipiracil Plus Bevacizumab Therapy in Patients With Metastatic Colorectal Cancer

  YUKI SEKI, MASATSUNE SHIBUTANI, HIDEKI TANDA, TOMOYA TSUKIDA, HIROAKI KASASHIMA, SHINICHIRO KASHIWAGI and KIYOSHI MAEDA

  Anticancer Research February 2026, 46 (2) 1117-1122; DOI: https://doi.org/10.21873/anticanres.18014
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  Differences of HER2 Status by HercepTest and PATHWAY 4B5 Immunohistochemical Assays in Breast Cancer

  SHINSUKE SASADA, MOMOKO TAKAYA, KANAKO SUZUKI, MUTSUMI FUJIMOTO, HARUKA IKEJIRI, AI AMIOKA, HIDEO SHIGEMATSU, KOJI ARIHIRO and MORIHITO OKADA

  Anticancer Research February 2026, 46 (2) 1123-1130; DOI: https://doi.org/10.21873/anticanres.18015
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  Awareness, Utilization, and Barriers to Fluorescence Ureteral Navigation in Japan: A Nationwide Survey Study

  SHUNJIN RYU, YUTA IMAIZUMI, SHUNSUKE NAKASHIMA, HYUGA KAWAKUBO, HIRONARI KAWAI, DAIKI SUZUKI, RYUSUKE ITO, KEISUKE GOTO, TEPPEI KAMADA and KEN ETO

  Anticancer Research February 2026, 46 (2) 1131-1141; DOI: https://doi.org/10.21873/anticanres.18016
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  Prognostic Factors for Pulmonary Metastasectomy for Colorectal Cancer: A Propensity Score Matching Analysis

  SHOJI OKADO, SHOTA NAKAMURA, MINORU SUGIHARA, FUMIE KINOSHITA, YOSHITO IMAMURA, YUJI NOMATA, HIROFUMI TAKENAKA, HIROKI WATANABE, YUTA KAWASUMI, KEITA NAKANISHI, YUKA KADOMATSU, HARUSHI UENO, TAKETO KATO, TETSUYA MIZUNO, TETSUO TANIGUCHI and TOYOFUMI FENGSHI CHEN-YOSHIKAWA

  Anticancer Research February 2026, 46 (2) 1143-1152; DOI: https://doi.org/10.21873/anticanres.18017