Article Figures & Data
Figures
- Figure 1.
Diverse immune cells constitute the meningioma TIME. (A) Representative image of CD4 (red), CD20 (brown), and BCL-6 (green) triple immunostaining. Red arrow, CD4+ monocytes/macrophages; red arrowhead CD4+ T-cells; brown arrowhead, CD20+ B-cells; green arrowhead, BCL-6+ T-cells. (B) Representative image of CD8 (red) and CD103 (green) double immunostaining. Pink arrowhead, CD8+ T-cells; black arrowhead, CD8+ CD103+ tissue-resident memory T-cells (TRMs). (C) Magnified image of the TRM in Figure B. (D) TIL aggregation composed of abundant CD20+ B-cells. Green arrow, CD4+ BCL-6+ follicular helper T-cells (Tfh). (E) Magnified image of the Tfh-cell in Figure D. The cell nuclei are positive for BCL-6 (green), and the surrounding cell membranes are positive for CD4 (red). (F) TIL aggregation mainly composed of CD4+ T-cells. Scale bar, 100 μm (A, B, and D), 50 μm (C and E), and 250 μm (F).
- Figure 2.
The densities of TIL aggregates in the meningioma TIME correlate with pathological tumor grades. (A) CD4+ monocyte/macrophages, (B) CD4+ T-cells, (C) CD8+ T-cells, (D) tissue-resident memory T-cells (TRMs), (E) CD20+ B-cells, and (F) TIL aggregates.
- Figure 3.
The density ratios of CD4+ T− and CD8+ T-cells are correlated in grade 2 meningiomas. (A) grade 1 and (B) grade 2 meningiomas.
