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Research ArticleExperimental Studies

Amentoflavone Enhances the Anti-tumor Activity of Regorafenib by Promoting Apoptosis and Inhibiting NF-κB–mediated Metastasis in Hepatocellular Carcinoma

KUANG-HSUAN LIN, CHIA-JUNG TSAI, YING-TZU CHEN, RONG-FONG LIN, FEI-TING HSU, CHE-CHENG SU and YU-CHENG KUO
Anticancer Research July 2025, 45 (7) 3045-3058; DOI: https://doi.org/10.21873/anticanres.17669
KUANG-HSUAN LIN
1Department of Radiation Oncology, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.
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CHIA-JUNG TSAI
2Department of Medical Imaging and Radiological Sciences, I-Shou University, Kaohsiung, Taiwan, R.O.C.
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YING-TZU CHEN
3Department of Dentistry, National Yang Ming Chiao Tung University, Taipei, Taiwan, R.O.C.
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RONG-FONG LIN
4Department of Optometry, Central Taiwan University of Science and Technology, Taichung, Taiwan, R.O.C.
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FEI-TING HSU
5Department of Life Sciences, National Central University, Taoyuan, Taiwan, R.O.C.
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CHE-CHENG SU
6Department of Emergency Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
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  • For correspondence: drccsu{at}gmail.com
YU-CHENG KUO
7School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.
8Department of Radiation Oncology, China Medical University Hsinchu Hospital, Hsinchu, Taiwan, R.O.C.
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  • For correspondence: shapico22{at}gmail.com
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Anticancer Research: 45 (7)
Anticancer Research
Vol. 45, Issue 7
July 2025
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Amentoflavone Enhances the Anti-tumor Activity of Regorafenib by Promoting Apoptosis and Inhibiting NF-κB–mediated Metastasis in Hepatocellular Carcinoma
KUANG-HSUAN LIN, CHIA-JUNG TSAI, YING-TZU CHEN, RONG-FONG LIN, FEI-TING HSU, CHE-CHENG SU, YU-CHENG KUO
Anticancer Research Jul 2025, 45 (7) 3045-3058; DOI: 10.21873/anticanres.17669

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Amentoflavone Enhances the Anti-tumor Activity of Regorafenib by Promoting Apoptosis and Inhibiting NF-κB–mediated Metastasis in Hepatocellular Carcinoma
KUANG-HSUAN LIN, CHIA-JUNG TSAI, YING-TZU CHEN, RONG-FONG LIN, FEI-TING HSU, CHE-CHENG SU, YU-CHENG KUO
Anticancer Research Jul 2025, 45 (7) 3045-3058; DOI: 10.21873/anticanres.17669
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Keywords

  • Regorafenib
  • Amentoflavone
  • Hepatocellular carcinoma
  • apoptosis
  • NF-κB
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