Table of Contents

Experimental Studies

• Open Access

  Fucoidan Treatment Leads to Attenuated Growth Factor Signaling and Reduced Proliferation in Neuroblastoma Cells

  NIKLAS WEBER, NINA SOPHIE POMMERT, MEIKE KAEHLER, INGOLF CASCORBI, SUSANNE ALBAN and VICKI WAETZIG

  Anticancer Research July 2025, 45 (7) 2749-2762; DOI: https://doi.org/10.21873/anticanres.17644
• Open Access

  Effects of Azelastine on Glioblastoma Cells

  YUKI UEMICHI, SEINA YASUDA, MIYUKI MABUCHI, SHUHEI NAKAO, SHUJI NAGANO and TADASHI SHIMIZU

  Anticancer Research July 2025, 45 (7) 2763-2771; DOI: https://doi.org/10.21873/anticanres.17645
• Open Access

  The Triple Combination of Recombinant Methioninase, Rapamycin, and Chloroquine Synergistically Eradicates HCT116 Colon Cancer Cells

  JINSOO KIM, QINGHONG HAN, BYUNG MO KANG, KOHEI MIZUTA, YOHEI ASANO, MICHAEL BOUVET and ROBERT M. HOFFMAN

  Anticancer Research July 2025, 45 (7) 2773-2779; DOI: https://doi.org/10.21873/anticanres.17646
• Open Access

  Apigenin-induced Apoptosis in Lung Adenocarcinoma A549 Cells: Involvement in IFNA2, TNF, and SPON2 With Different Time Points

  RIEKO AIDA, KAZUNORI OKANO, KYOKO NAKATA and HIROMI HAGIWARA

  Anticancer Research July 2025, 45 (7) 2781-2790; DOI: https://doi.org/10.21873/anticanres.17647
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  Heterogeneous c-Met Activation in Osteosarcoma Dictates Synergistic Vulnerability to Combined c-Met Inhibition and Methotrexate Therapy

  GUIDONG LI, HIROYUKI KAWASHIMA, TARO SASAKI, TAKASHI ARIIZUMI, NAOKI OIKE and AKIRA OGOSE

  Anticancer Research July 2025, 45 (7) 2791-2806; DOI: https://doi.org/10.21873/anticanres.17648
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  Development of a Benzoxazine-derived Inhibitor Targeting Epithelial-to-Mesenchymal Transition in Lung Cancer

  NAPHATSON PHANSOM, ZIN ZIN EI, BHURICHAYA INNETS, WORAWAT WATTANATHANA, THEERA RITTIROD, ACHARAWAN THONGMEE, KEERATI JOYJAMRAS and PITHI CHANVORACHOTE

  Anticancer Research July 2025, 45 (7) 2807-2815; DOI: https://doi.org/10.21873/anticanres.17649
• Open Access

  The Conditions of Non-rescuability of Methioninase-treated Cancer Cells by Methionine Replenishment: The Point of No Return

  BYUNG MO KANG, QINGHONG HAN, SHUKUAN LI, KOHEI MIZUTA, JIN SOO KIM, YOHEI ASANO, MICHAEL BOUVET and ROBERT M. HOFFMAN

  Anticancer Research July 2025, 45 (7) 2817-2823; DOI: https://doi.org/10.21873/anticanres.17650
• Open Access

  The Combination of the Autophagy Inhibitor Chloroquine and Recombinant Methioninase Has Selective Synergistic Efficacy on Human Colon Cancer Cells But Not on Normal Human Fibroblasts

  YOHEI ASANO, QINGHONG HAN, SHUKUAN LI, KOHEI MIZUTA, BYUNG MO KANG, JIN SOO KIM, YUTA MIYASHI, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, SEI MORINAGA, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

  Anticancer Research July 2025, 45 (7) 2825-2831; DOI: https://doi.org/10.21873/anticanres.17651
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  Artogomezianone Inhibits EGFR and Promotes Apoptosis in Non-small Cell Lung Cancer Cells

  WORAWICH SOMBOONVORAVONG, KORRAKOD PETSRI, SATAPAT RACHA, NICHARAT SRIRATANASAK, KEERATI JOYJAMRAS, BOONCHOO SRITULARAK and PITHI CHANVORACHOTE

  Anticancer Research July 2025, 45 (7) 2833-2845; DOI: https://doi.org/10.21873/anticanres.17652
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  Damnacanthal Suppresses TCF4 Expression in Colorectal Cancer Cells

  JAEHAK LEE, HAYEUN KIM, JIYOUNG MOON, THARARAT NUALSANIT, WORAPAPAR TREESUPPHARAT and SEUNG JOON BAEK

  Anticancer Research July 2025, 45 (7) 2847-2858; DOI: https://doi.org/10.21873/anticanres.17653
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  Macranthoside B Enhances Paclitaxel-induced Human Cervical Cancer Cell Apoptosis Through ROS-JNK Pathway

  MENGLING LI, JIE YAN, SHUAIJIE WEI, SONGJI ZHAO, ZHENG-GUO CUI and XIAOPENG TONG

  Anticancer Research July 2025, 45 (7) 2859-2870; DOI: https://doi.org/10.21873/anticanres.17654
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  Cytotoxic and Metalloproteinase-inhibitory Effects of Ellagic Acid Against Oral Squamous Cell Carcinoma

  PATRICIA MARIA WIZIACK ZAGO, LUIZA RODRIGUES HELLMEISTER, LUCAS NOVAES TEIXEIRA, RUI BARBOSA DE BRITO JUNIOR and ELIZABETH FERREIRA MARTINEZ

  Anticancer Research July 2025, 45 (7) 2871-2880; DOI: https://doi.org/10.21873/anticanres.17655
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  Study of the Cytotoxic and Antitumor Effect of L-lysine-α-oxidase from Trichoderma harzianum Rifai

  IRINA P. SMIRNOVA, EKATERINA V. NEBORAK, VICTOR F. LARICHEV, LYUDMILA A. GAVRILYUK and DMITRY D. ZHDANOV

  Anticancer Research July 2025, 45 (7) 2881-2889; DOI: https://doi.org/10.21873/anticanres.17656
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  Anti-cancer Effects of a Novel Curcumin Derivative, 4,4-Diallyl Curcumin Bis(2,2-Hydroxymethyl)Propanoate (35e), on Radio-resistant Colorectal Cancer Cells

  CHING-WEN HUANG, JAI-SING YANG, YUH-FENG TSAI, SHENG-CHU KUO, YU-NING JUAN, MENG-WEI LIN, YU-JEN CHIU and CHUNG-HUA HSU

  Anticancer Research July 2025, 45 (7) 2891-2904; DOI: https://doi.org/10.21873/anticanres.17657
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  High Antitumor Effects and Reduced Side Effects of Doxorubicin Prodrug Active Only Under Hypoxic Conditions

  KOKI YOSHIOKA, TAISUKE FURUTA, TOMOHIKO SAKUDA, AKIHIRO ODA, YUTAKA IKEDA, SHIGERU MIYAKI, YUKIO NAGASAKI and NOBUO ADACHI

  Anticancer Research July 2025, 45 (7) 2905-2916; DOI: https://doi.org/10.21873/anticanres.17658
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  Effective Targeting of Glioma Stem Cells by BSJ-04-122, a Novel Covalent MKK4/7 Dual Inhibitor

  KAZUKI NAKAMURA, YASUFUMI ITO, SENRI TAKENOUCHI, YURIKA NAKAGAWA-SAITO, SHUHEI SUZUKI, KEITA TOGASHI, ASUKA SUGAI, YUTA MITOBE, YUKIHIKO SONODA, CHIFUMI KITANAKA and MASASHI OKADA

  Anticancer Research July 2025, 45 (7) 2917-2924; DOI: https://doi.org/10.21873/anticanres.17659
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  The Polyphenol (−)-Epigallocatechin-3-gallate (EGCG) Inhibits the Proliferation of Gastric Cancer Cells and Alters microRNA Signatures

  KOTA SASAKI, KOJI FUJITA, SHINTARO FUJIHARA, HISAKAZU IWAMA, ATSUO KITAOKA, FUMIYUKI SUETSUGU, SHIMA MIMURA, JOJI TANI, ASAHIRO MORISHITA, TSUTOMU MASAKI and HIDEKI KOBARA

  Anticancer Research July 2025, 45 (7) 2925-2936; DOI: https://doi.org/10.21873/anticanres.17660
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  Antitumor Effects of Epigallocatechin-3-Gallate on Colorectal Cancer: An In Vitro and In Vivo Study

  FUMIYUKI SUETSUGU, TOMOKO TADOKORO, KOJI FUJITA, SHINTARO FUJIHARA, KOTA SASAKI, ERIKA OMAYU, KAHO NAKATANI, YUKIKO KOYAMA, KAZUHIRO KOZUKA, TAKANORI MATSUI, MAI NAKAHARA, KYOKO OURA, ATSUO KITAOKA, TATSUO YACHIDA, JOJI TANI, ASAHIRO MORISHITA, TSUTOMU MASAKI and HIDEKI KOBARA

  Anticancer Research July 2025, 45 (7) 2937-2947; DOI: https://doi.org/10.21873/anticanres.17661
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  Magnolol Suppresses Osteosarcoma Progression via Apoptosis Induction and EGFR/AKT Pathway Inactivation in a U-2 OS Xenograft Model

  CHI-HUAN LI, CHIA-JUNG TSAI, FEI-TING HSU, BING-RU PENG, MAO-CHI WENG, TSAI-LAN LIAO, HSIAO-CHIA WANG, CHING-YU HAN and JIANN-HWA CHEN

  Anticancer Research July 2025, 45 (7) 2949-2961; DOI: https://doi.org/10.21873/anticanres.17662
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  Integrating Network Pharmacology and Optimization of Preparation Methods to Enhance the Anticancer Effect of Cordyceps militaris on Lung Cancer

  HYE-LIN KIM, JUNKYU PARK, HYO IN KIM, MINA BOO, JAE HEON SIM, HARIM KIM, HYUNYOUNG CHOI, SUHYEON AN, HYUNSOO YANG, SUJIN SHIN, YOHAN HAN, HYOJEONG KIM, JINBONG PARK and KYUNGJIN LEE

  Anticancer Research July 2025, 45 (7) 2963-2984; DOI: https://doi.org/10.21873/anticanres.17663
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  Tetrahydroindazolone-substituted Benzamide Compound W-H4 Induces Apoptosis and Autophagy of Acute Myeloid Leukemia Cells

  YAWEN LI, SHENG WANG, HAN WANG, JIAHUA ZOU, CHUIWEN QIAN and ZHONG LIU

  Anticancer Research July 2025, 45 (7) 2985-2996; DOI: https://doi.org/10.21873/anticanres.17664
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  ITGAV Regulation of LGALS3BP-JUNB Axis Facilitates the Cell-to-Cell Adhesion and Invasiveness of Hepatic Cancer Cells

  HYUN JEONG SHIM, MYONG-SUK PARK, WOO-KYUN BAE, SANG-HEE CHO, IK-JOO CHUNG and DAE-HWAN KIM

  Anticancer Research July 2025, 45 (7) 2997-3008; DOI: https://doi.org/10.21873/anticanres.17665
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  Piperine Targets MAOB and Enhances Temozolomide-induced Cytotoxicity in Glioblastoma Cell Lines

  HYEON JI KIM, CHANG-HOON SHIN, TAE-JUN KIM and DO-YEON KIM

  Anticancer Research July 2025, 45 (7) 3009-3020; DOI: https://doi.org/10.21873/anticanres.17666
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  Resveratrol Derivatives Inhibit Pro-survival Akt Signaling Pathway in Lung Cancer

  BHURICHAYA INNETS, SATAPAT RACHA, ZIN ZIN EI, NICHARAT SRIRATANASAK and PITHI CHANVORACHOTE

  Anticancer Research July 2025, 45 (7) 3021-3029; DOI: https://doi.org/10.21873/anticanres.17667
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  Physalin F Inhibits Cell Viability and Induces Apoptosis in Non-small Cell Lung Cancer Cells

  JHY-MING LI, KAO-TAI YANG and CHEAN-PING WU

  Anticancer Research July 2025, 45 (7) 3031-3044; DOI: https://doi.org/10.21873/anticanres.17668
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  Amentoflavone Enhances the Anti-tumor Activity of Regorafenib by Promoting Apoptosis and Inhibiting NF-κB–mediated Metastasis in Hepatocellular Carcinoma

  KUANG-HSUAN LIN, CHIA-JUNG TSAI, YING-TZU CHEN, RONG-FONG LIN, FEI-TING HSU, CHE-CHENG SU and YU-CHENG KUO

  Anticancer Research July 2025, 45 (7) 3045-3058; DOI: https://doi.org/10.21873/anticanres.17669
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  Adiponectin Receptor Agonist Suppresses Human Colorectal Cancer

  MAI LY THI NGUYEN, LAN ANH BUI, CHI PHAM, PHUONG LINH THI NHAM, VAN MAO CAN, TRAN DUY HAI DOAN, PRZEMYSLAW BOZKO, KHAC CUONG BUI and LINH TOAN NGUYEN

  Anticancer Research July 2025, 45 (7) 3059-3068; DOI: https://doi.org/10.21873/anticanres.17670
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  Bis-type Triaziquone Induces Apoptotic Effects in Human OEC-M1 Oral Cancer Cells

  CHUNG-CHI HSU, BU-MIIN HUANG, YENG-TING WU, CHIH-CHUN WANG, CHIH-CHIEH TAO, YUH-LING LIN and YU-YAN LAN

  Anticancer Research July 2025, 45 (7) 3069-3075; DOI: https://doi.org/10.21873/anticanres.17671
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  A Novel Three Small Molecule Inhibitor Combination Therapy For Prostate Cancer

  UMMUHAN DEMIR, HILAL BADOGLU, IREM NUR CETIN and MUHAMMED YASAR BENER

  Anticancer Research July 2025, 45 (7) 3077-3087; DOI: https://doi.org/10.21873/anticanres.17672
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  Ketone Bodies Inhibit Growth of Hepatoblastoma and Rhabdoid Tumor of the Kidney Cells

  ERI MUTO-FUJITA, BIN YAMAOKA, NAOKO ABE, KYOKO FUJIWARA and SHUICHIRO UEHARA

  Anticancer Research July 2025, 45 (7) 3089-3097; DOI: https://doi.org/10.21873/anticanres.17673
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  Periostin Promotes Invasiveness and Metastasis of Oral Cancer via Epithelial-mesenchymal Transition

  SEONGJUN WON, YOUNG-SOOL HAH, SO YOUNG CHEON, CHAE DONG YIM, SANG-WOOK PARK, SEUNG-JUN LEE, JI HYUN SEO and JUNG JE PARK

  Anticancer Research July 2025, 45 (7) 3099-3115; DOI: https://doi.org/10.21873/anticanres.17674
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  Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhance Cisplatin-induced Apoptotic Effects via the ROS-Fas Pathway in Human NPC-TW01 Nasopharyngeal Carcinoma Cells

  YINGXIAO LI, BU-MIIN HUANG, CHIH-CHIEH TAO and YU-YAN LAN

  Anticancer Research July 2025, 45 (7) 3117-3126; DOI: https://doi.org/10.21873/anticanres.17675