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Research ArticleClinical Studies

Combined Biomarkers for Prediction of Immune Checkpoint Inhibitor Response in Patients With Triple-negative Breast Cancer

HAN GYEOL KIM, SO YOUNG KANG, KYOUNG-MEE KIM, JI-YEON KIM, YEON HEE PARK, JIN SEOK AHN, YOUNG-HYUCK IM, YOOJOO LIM, SANGHOON SONG, KYUNGHYUN PAENG and EUN YOON CHO
Anticancer Research June 2025, 45 (6) 2575-2586; DOI: https://doi.org/10.21873/anticanres.17629
HAN GYEOL KIM
1Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
2Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea;
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SO YOUNG KANG
1Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
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KYOUNG-MEE KIM
1Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
3Center of Companion Diagnostics, Samsung Medical Center, Seoul, Republic of Korea;
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JI-YEON KIM
4Division of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
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YEON HEE PARK
4Division of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
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JIN SEOK AHN
4Division of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
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YOUNG-HYUCK IM
4Division of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
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YOOJOO LIM
5Lunit, Seoul, Republic of Korea
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SANGHOON SONG
5Lunit, Seoul, Republic of Korea
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KYUNGHYUN PAENG
5Lunit, Seoul, Republic of Korea
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EUN YOON CHO
1Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
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  • For correspondence: eunyoon.cho{at}samsung.com
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Article Information

vol. 45 no. 6 2575-2586
DOI 
https://doi.org/10.21873/anticanres.17629
PMID 
40425338

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received February 12, 2025
  • Revision received April 10, 2025
  • Accepted April 16, 2025
  • Published online May 27, 2025.

Copyright & Usage 
Copyright © 2025 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. HAN GYEOL KIM1,2,*,
  2. SO YOUNG KANG1,*,
  3. KYOUNG-MEE KIM1,3,
  4. JI-YEON KIM4,
  5. YEON HEE PARK4,
  6. JIN SEOK AHN4,
  7. YOUNG-HYUCK IM4,
  8. YOOJOO LIM5,
  9. SANGHOON SONG5,
  10. KYUNGHYUN PAENG5 and
  11. EUN YOON CHO1⇑
  1. 1Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
  2. 2Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea;
  3. 3Center of Companion Diagnostics, Samsung Medical Center, Seoul, Republic of Korea;
  4. 4Division of Hematology-Oncology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;
  5. 5Lunit, Seoul, Republic of Korea
  1. Eun Yoon Cho, Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, #81, Irwon-ro, Gangnam-Gu, Seoul 06351, Republic of Korea. Tel: +82 234102796, Fax: +82 234106396, e-mail: eunyoon.cho{at}samsung.com
  1. ↵* These Authors contributed equally to this work as first authors.

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Combined Biomarkers for Prediction of Immune Checkpoint Inhibitor Response in Patients With Triple-negative Breast Cancer
HAN GYEOL KIM, SO YOUNG KANG, KYOUNG-MEE KIM, JI-YEON KIM, YEON HEE PARK, JIN SEOK AHN, YOUNG-HYUCK IM, YOOJOO LIM, SANGHOON SONG, KYUNGHYUN PAENG, EUN YOON CHO
Anticancer Research Jun 2025, 45 (6) 2575-2586; DOI: 10.21873/anticanres.17629

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Combined Biomarkers for Prediction of Immune Checkpoint Inhibitor Response in Patients With Triple-negative Breast Cancer
HAN GYEOL KIM, SO YOUNG KANG, KYOUNG-MEE KIM, JI-YEON KIM, YEON HEE PARK, JIN SEOK AHN, YOUNG-HYUCK IM, YOOJOO LIM, SANGHOON SONG, KYUNGHYUN PAENG, EUN YOON CHO
Anticancer Research Jun 2025, 45 (6) 2575-2586; DOI: 10.21873/anticanres.17629
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Keywords

  • biomarker
  • immune checkpoint inhibitors
  • Tumor-infiltrating lymphocytes
  • Triple-negative breast cancer
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