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Research ArticleClinical Studies

Blood Concentrations of Osimertinib and Its Active Metabolites: Impact on Treatment Efficacy and Safety

TAKAE OKUNO, MASAFUMI HONGOH, RYOSUKE TANINO, TAMIO OKIMOTO, YUKARI TSUBATA and TAKESHI ISOBE
Anticancer Research June 2025, 45 (6) 2551-2561; DOI: https://doi.org/10.21873/anticanres.17627
TAKAE OKUNO
1Division of Medical Oncology and Respiratory Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine, Shimane, Japan;
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MASAFUMI HONGOH
2Department of Pharmacy, Shimane University Hospital, Shimane, Japan
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RYOSUKE TANINO
1Division of Medical Oncology and Respiratory Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine, Shimane, Japan;
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TAMIO OKIMOTO
1Division of Medical Oncology and Respiratory Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine, Shimane, Japan;
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  • For correspondence: okimoto{at}med.shimane-u.ac.jp
YUKARI TSUBATA
1Division of Medical Oncology and Respiratory Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine, Shimane, Japan;
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TAKESHI ISOBE
1Division of Medical Oncology and Respiratory Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine, Shimane, Japan;
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Anticancer Research: 45 (6)
Anticancer Research
Vol. 45, Issue 6
June 2025
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Blood Concentrations of Osimertinib and Its Active Metabolites: Impact on Treatment Efficacy and Safety
TAKAE OKUNO, MASAFUMI HONGOH, RYOSUKE TANINO, TAMIO OKIMOTO, YUKARI TSUBATA, TAKESHI ISOBE
Anticancer Research Jun 2025, 45 (6) 2551-2561; DOI: 10.21873/anticanres.17627

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Blood Concentrations of Osimertinib and Its Active Metabolites: Impact on Treatment Efficacy and Safety
TAKAE OKUNO, MASAFUMI HONGOH, RYOSUKE TANINO, TAMIO OKIMOTO, YUKARI TSUBATA, TAKESHI ISOBE
Anticancer Research Jun 2025, 45 (6) 2551-2561; DOI: 10.21873/anticanres.17627
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Keywords

  • Osimertinib
  • NSCLC
  • AZ5104
  • AZ7550
  • blood concentration
  • adverse events
  • efficacy
  • hematological toxicity
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