Anticancer Research: 45 (6)

June 2025; Volume 45,Issue 6

Reviews

Open Access
De Novo Testicular Cancers Arising After Renal Transplantation: A Narrative Review
LUCIO DELL’ATTI and VIKTORIA SLYUSAR

Anticancer Research June 2025, 45 (6) 2239-2247; DOI: https://doi.org/10.21873/anticanres.17598
Open Access
Mobile and Wireless Technologies for Gastrointestinal Cancer Treatment
TORU AOYAMA, HARUHIKO CHO and KENTARO HARA

Anticancer Research June 2025, 45 (6) 2249-2256; DOI: https://doi.org/10.21873/anticanres.17599

Experimental Studies

Open Access
Selective Synergy of Ivermectin Combined With Recombinant Methioninase Against Colon-Cancer Cells in Contrast to Normal Fibroblasts
YOHEI ASANO, QINGHONG HAN, SHUKUAN LI, KOHEI MIZUTA, BYUNG MO KANG, JIN SOO KIM, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, SEI MORINAGA, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Anticancer Research June 2025, 45 (6) 2257-2263; DOI: https://doi.org/10.21873/anticanres.17600
Open Access
Acyclic Retinoid Overcomes Vemurafenib Resistance in Melanoma Cells via Dual Inhibition of MAPK and PI3K/AKT/mTOR Pathways
YUI SUZUKI, SOICHIRO USUKI, MITSUAKI NISHIZAWA, NORIYOSHI TANAKA, YOSHITOMO SUHARA and ICHIRO YAJIMA

Anticancer Research June 2025, 45 (6) 2265-2278; DOI: https://doi.org/10.21873/anticanres.17601
Open Access
Tumor Immunology Visualized in Realtime in In-vivo-like 3-D Gelfoam^® Histoculture by Color-coded Imaging
KOHEI MIZUTA, JOSE REYNOSO, YOHEI ASANO, BYUNG MO KANG, JIN SOO KIM, MICHAEL BOUVET, YASUNORI TOME, KOTARO NISHIDA and ROBERT M. HOFFMAN

Anticancer Research June 2025, 45 (6) 2279-2283; DOI: https://doi.org/10.21873/anticanres.17602
Open Access
Trametinib Synergized With Abemaciclib to Inhibit Tumor Growth in Human Head and Neck Squamous Cell Carcinoma Cells
ERNEST DUAH, MING POI and JUNAN LI

Anticancer Research June 2025, 45 (6) 2285-2295; DOI: https://doi.org/10.21873/anticanres.17603
Open Access
Association of Interleukin-12A Genotypes With Nasopharyngeal Carcinoma Risk
KAI-YUAN CHEN, CHE-LUN HSU, SHIH-WEI HSU, YEN-FANG LIU, YUN-CHI WANG, HOU-YU SHIH, WEN-SHIN CHANG, DA-TIAN BAU and CHIA-WEN TSAI

Anticancer Research June 2025, 45 (6) 2297-2308; DOI: https://doi.org/10.21873/anticanres.17604
Open Access
Role of the Circadian Clock Gene DEC1 in Chemosensitivity and Apoptosis in Colorectal Cancer
SOICHIRO MINAMI, NORIKATSU MIYOSHI, SHIKI FUJINO, MASAYOSHI YASUI, MASAYUKI OHUE, MITSUNOBU TAKEDA, YUKI SEKIDO, TSUYOSHI HATA, ATSUSHI HAMABE, TAKAYUKI OGINO, MAMORU UEMURA, HIROFUMI YAMAMOTO, YUICHIRO DOKI and HIDETOSHI EGUCHI

Anticancer Research June 2025, 45 (6) 2309-2328; DOI: https://doi.org/10.21873/anticanres.17605
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Enhanced DNA Double-strand Break Induction by Carbon Ions Under Intratumoral Hypoxia
AKIKO ADACHI, TAKAHIRO OIKE, RYOSUKE KAMBE, YUKARI YOSHIDA, AKIHISA TAKAHASHI, YUKA HIROTA and TATSUYA OHNO

Anticancer Research June 2025, 45 (6) 2329-2337; DOI: https://doi.org/10.21873/anticanres.17606
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Antitumor Activity of Ex Vivo Expanded Tumor Antigen Priming Cytotoxic T Cells Against Malignant Melanoma
HOE-SUN YOON, YOUNG GYU PARK, DAE YOEN CHO, JONG-SEOK KIM and JONG GWON CHOI

Anticancer Research June 2025, 45 (6) 2339-2350; DOI: https://doi.org/10.21873/anticanres.17607
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In Vitro Evaluation of the Dual Pharmacological Action of Vitamin D₃ as Cardio-protectant and Anti-cancer Agent
YESENIA L. FRANCO, HARDIK MODY and SIHEM AIT-OUDHIA

Anticancer Research June 2025, 45 (6) 2351-2363; DOI: https://doi.org/10.21873/anticanres.17608
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Predictive Factors for Multiple Metastases of Clear-cell Renal Cell Carcinoma
ANDREI-ALEXANDRU COSMA, ALINA GABRIELA NEGRU, OVIDIU CATALIN FERICIAN, MIHAELA MARIA PASCA FENESAN, VLAD VORNICU, ADELA MARIA FERICIAN, EUGEN MELNIC and ANCA MARIA CIMPEAN

Anticancer Research June 2025, 45 (6) 2365-2375; DOI: https://doi.org/10.21873/anticanres.17609
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C-myc Oncogene Numerical Imbalances Analysis in Laryngeal Squamous Cell Carcinoma
SOTIRIOS PAPOULIAKOS, VASILEIOS PAPANIKOLAOU, ARISTEIDIS CHRYSOVERGIS, EVANGELOS TSIAMBAS, DIMITRIOS ROUKAS, SOFIANIKI MASTRONIKOLI, GEORGE TSOUVELAS, GEORGE AGROGIANNIS, NIKOLAOS KAVANTZAS, VASILEIOS RAGOS, ANDREAS LAZARIS and EFTHYMIOS KYRODIMOS

Anticancer Research June 2025, 45 (6) 2377-2383; DOI: https://doi.org/10.21873/anticanres.17610
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Immunogenicity of Neoantigens in Colorectal Cancer: Potential Influence of Tumor Mutation Burden, Stages, and Metastasis
XIAOLIN YU, RYOUICHI TSUNEDOMI, SHOICHI HAZAMA, YUKI NAKAGAMI, SHINOBU TOMOCHIKA, MICHIHISA IIDA, TATSUYA IOKA, HIDENORI TAKAHASHI, KOJI TAMADA and HIROAKI NAGANO

Anticancer Research June 2025, 45 (6) 2385-2399; DOI: https://doi.org/10.21873/anticanres.17611
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Tissue Prognostic Markers for Clear Cell Renal Cell Carcinoma Tumor-stroma Interaction: Impact on TNM Staging Parameters
ANDREI ALEXANDRU COSMA, ALINA GABRIELA NEGRU, OVIDIU CATALIN FERICIAN, MIHAELA MARIA PASCA FENESAN, VLAD VORNICU, ADELA MARIA FERICIAN, EUGEN MELNIC and ANCA MARIA CIMPEAN

Anticancer Research June 2025, 45 (6) 2401-2416; DOI: https://doi.org/10.21873/anticanres.17612
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The Role of EMP2 in Triple-negative Breast Cancer
IN HEE LEE, EUN AE KIM, SOO JUNG LEE, BYEONGJU KANG, JEEYEON LEE, JIN HYANG JUNG, HO YONG PARK, JI-YOUNG PARK, NORA JEE-YOUNG PARK, JIEUN KANG and YEE SOO CHAE

Anticancer Research June 2025, 45 (6) 2417-2427; DOI: https://doi.org/10.21873/anticanres.17613
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CA9-Positive Keloid Fibroblasts: Modulator of Local Inflammation Induced by the Hypoxic and Glycolysis-enhanced Microenvironment
AIHUA GAO, ZHENLONG ZHENG, MI RYUNG ROH, GUOHUA ZHAO, MI YEON CHO, NA YEONG CHO, KEE YANG CHUNG, HAORAN XI and XIANGLAN ZHANG

Anticancer Research June 2025, 45 (6) 2429-2442; DOI: https://doi.org/10.21873/anticanres.17614

Clinical Studies

Open Access
Impact of Surgery Refusal on Overall Survival in Merkel Cell Carcinoma
KYLE POPP, REED POPP, JADE BOWERS, SYEDA HOORULAIN AHMED, RAMIN SHEKOUHI, SHIVAM BANSAL, SEEMA SHARAN, HARSHEEN K. MANAISE, BANSI P. SAVALIY, SWATHI R. RAIKOT, PAOLA BERRIOS JIMENEZ, FATIMA MUBARAK, ESINAM P. EKPEH, KULKAEW B. SUKNIAM, GABRIELLE KOWKABANY, ANGEL AGUAYO and EMMANUEL M. GABRIEL

Anticancer Research June 2025, 45 (6) 2443-2451; DOI: https://doi.org/10.21873/anticanres.17615
Open Access
In-hospital Outcomes Between Total Parenteral Nutrition and Enteral Feeding in Esophageal and Gastric Cancer: A Nationwide Analysis
SURIYA BASKAR, ROBERT SCHOENEICH and UDHAYVIR S. GREWAL

Anticancer Research June 2025, 45 (6) 2453-2457; DOI: https://doi.org/10.21873/anticanres.17616
Open Access
Liposarcomas of the Kidney and Surgical Management
JACK D. SLEEMAN, JESSICA DELGADO, DANNY SLEEMAN, MARINA M. TABBARA and GAETANO CIANCIO

Anticancer Research June 2025, 45 (6) 2459-2465; DOI: https://doi.org/10.21873/anticanres.17617
Open Access
Gastrojejunostomy for Asymptomatic Gastric Outlet Obstruction in Pancreatic Cancer May Contribute to Early Recovery
KATSUHISA HIRANO, ISAYA HASHIMOTO, NANA KIMURA, MINA FUKASAWA, RYO MURANUSHI, YOSHIHIRO SHIRAI, TORU WATANABE, KAZUTO SHIBUYA, ISAKU YOSHIOKA and TSUTOMU FUJII

Anticancer Research June 2025, 45 (6) 2467-2476; DOI: https://doi.org/10.21873/anticanres.17618
Open Access
Four Different Artificial Intelligence Models Versus Logistic Regression to Enhance the Diagnostic Accuracy of Fecal Immunochemical Test in the Detection of Colorectal Carcinoma in a Screening Setting
MAARET ESKELINEN, TUOMAS SELANDER, DENISE PEIXOTO GUIMARÃES, KAI KAARNIRANTA, KARI SYRJÄNEN and MATTI ESKELINEN

Anticancer Research June 2025, 45 (6) 2477-2491; DOI: https://doi.org/10.21873/anticanres.17619
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Pathological Investigation of Grasping-related Mesenteric Injury During Laparoscopic Colorectal Cancer Resection
ATSUKO KATAOKA, TOMONORI KAWASAKI, KYOICHI KAIRA and YASUMITSU HIRANO

Anticancer Research June 2025, 45 (6) 2493-2499; DOI: https://doi.org/10.21873/anticanres.17620
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Pathologic Complete Response (pCR) in Patient With Myxofibrosarcoma Who Underwent Neoadjuvant Radiation Concurrent to Complementary and Alternative Medicine
GUSTAVO MIRANDA, MARWAN SHECKLEY, ROBERT R. KLEIN, ROBERT GIN, TOLGA TURKER and JENNIFER ERDRICH

Anticancer Research June 2025, 45 (6) 2501-2505; DOI: https://doi.org/10.21873/anticanres.17621
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Association of County-level Social Determinants and Pancreatic Cancer Incidence in the United States
KENNETH LUBERICE, MICHAEL C. CANTRELL, LAUREN EDGAR, CARMEN SMOTHERMAN, CHRISTINA GUERRIER, RAMZI G. SALLOUM, ALEXANDER S. PARKER, ERIN M. MOBLEY and ZIAD T. AWAD

Anticancer Research June 2025, 45 (6) 2507-2514; DOI: https://doi.org/10.21873/anticanres.17622
Open Access
Clinical Outcomes of Metastasis-directed Therapy for Oligo-metastatic Prostate Cancer Diagnosed Using PSMA-PET/CT or Whole-body MRI
RIHITO AIZAWA, TAKASHI OGATA, TAKAYUKI GOTO, TOMOAKI OTANI, KIYONAO NAKAMURA, YUKI KITA, RYUSUKE NAKAMOTO, YOICHI SHIMIZU, TAKAYUKI SUMIYOSHI, KAORU MURAKAMI, KEI MIZUNO, TAKASHI KOBAYASHI, YUJI NAKAMOTO and TAKASHI MIZOWAKI

Anticancer Research June 2025, 45 (6) 2515-2525; DOI: https://doi.org/10.21873/anticanres.17623
Open Access
Efficacy and Treatment Outcomes of First-line Pazopanib Therapy in Advanced Renal Cell Carcinoma in Greece
EVANGELOS BOURNAKIS, IOANNIS XANTHAKIS, MICHAIL VASLAMATZIS, PARISIS MAKRANTONAKIS, CHARISIOS KARANIKIOTIS, ILIAS ATHANASIADIS, ALEXANDROS ARDAVANIS, PAVLOS PAPAKOTOULAS, EPAMINONDAS SAMANTAS, CHRISTOS PAPANDREOU, MARIA MICHAILIDOU, PANAGIOTIS KATSAOUNIS and CHRISTOS CHRISTODOULOU

Anticancer Research June 2025, 45 (6) 2527-2534; DOI: https://doi.org/10.21873/anticanres.17624
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End-of-life Androgen Deprivation Syndrome With Enzalutamide in Metastatic Prostate Cancer: A Case Report
MINH DUNG NGUYEN, OLENA GOROBETS, YANNICK JOEL DJOUA, JOHAN ROSE-DITE-MODESTINE, VINCENT VINH-HUNG, CLAIRE VERSCHRAEGEN and NAM P. NGUYEN

Anticancer Research June 2025, 45 (6) 2535-2538; DOI: https://doi.org/10.21873/anticanres.17625
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Phase II Study of the Effectiveness of the Germinated Wheat-derived Rigenase Plus Polyhexanide in the Prophylaxis for Hypofractionated Radiation-induced Acute Skin Toxicity in Breast Cancer
VINCENZO IORIO, PIETRO DELIA, ANGELA PIA SOLAZZO, IVAN FAZIO, ANTONINO DAIDONE, ANDREA GIRLANDO, NICOLA DE ROSA, ALFIO DI GRAZIA, ANNALISA LA MACCHIA, SANTA BAMBACE, SALVATORE PARISI, CESARE GUIDA, MATTEO MUTO, VINCENZO CARFORA, MARIANGELA BOCCARDI, SALVATORE BONANNO, FRANCESCA DORIA, ALFONSINA PEPE, GIUSEPPE IATÌ, ANTONIO SPERA, GIANLUCA MORTELLARO, ALESSANDRO FANELLI, VINCENZO BARONE, PAOLO MUTO, MARIA ROSARIA VALERIO, GIUSEPPA SCANDURRA, DANIELA SAMBATARO, GRAZIA LAZZARI, MARIA ENFASI and VITTORIO GEBBIA

Anticancer Research June 2025, 45 (6) 2539-2550; DOI: https://doi.org/10.21873/anticanres.17626
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Blood Concentrations of Osimertinib and Its Active Metabolites: Impact on Treatment Efficacy and Safety
TAKAE OKUNO, MASAFUMI HONGOH, RYOSUKE TANINO, TAMIO OKIMOTO, YUKARI TSUBATA and TAKESHI ISOBE

Anticancer Research June 2025, 45 (6) 2551-2561; DOI: https://doi.org/10.21873/anticanres.17627
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Efficacy of Pembrolizumab as Second or Third-line Therapy for Local Advanced and Metastatic Urothelial Cancer
TOMOHIRO MATSUO, YASUYOSHI MIYATA, JUNKI HARADA, ITSUHO ITOH, TSUYOSHI MATSUDA, AKIHIRO ASAI, TSUBASA KONDO, HIROKI KURATA, SUZUNA SAKAI, HIDENORI ITOH, KENSUKE MITSUNARI and RYOICHI IMAMURA

Anticancer Research June 2025, 45 (6) 2563-2573; DOI: https://doi.org/10.21873/anticanres.17628
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Combined Biomarkers for Prediction of Immune Checkpoint Inhibitor Response in Patients With Triple-negative Breast Cancer
HAN GYEOL KIM, SO YOUNG KANG, KYOUNG-MEE KIM, JI-YEON KIM, YEON HEE PARK, JIN SEOK AHN, YOUNG-HYUCK IM, YOOJOO LIM, SANGHOON SONG, KYUNGHYUN PAENG and EUN YOON CHO

Anticancer Research June 2025, 45 (6) 2575-2586; DOI: https://doi.org/10.21873/anticanres.17629
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Effect of a Biweekly Dosing Schedule on Severe Neutropenia Induced by Trifluridine/Tipiracil in Colorectal Cancer
YOSUKE ANDO, HANAHO ORITO, TOMOHIRO MIZUNO, HIDETOSHI KATSUNO, ZENICHI MORISE, AKIHIKO HORIGUCHI, HIROSHI MATSUOKA, KOICHI SUDA, TAKAHIRO HAYASHI and SHIGEKI YAMADA

Anticancer Research June 2025, 45 (6) 2587-2594; DOI: https://doi.org/10.21873/anticanres.17630
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Prognostic Nutritional Index Is the Key Prognostic Factor in Elderly Patients With Colorectal Cancer
YASUNOBU KOBAYASHI, YASUHIRO TAKANO, SAYA MATSUKIDA, TERUYUKI TAKISHIMA, WATARU KAI, SHU TSUKIHARA, DAISUKE ITO, HIRONORI KANNO, NOBUYOSHI HANYU and KEN ETO

Anticancer Research June 2025, 45 (6) 2595-2603; DOI: https://doi.org/10.21873/anticanres.17631
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Feasibility of an Exercise Training Program Among Patients With Newly Diagnosed Advanced Breast Cancer
KRISTIINA KOKKONEN, MERI UTRIAINEN, HEIDI PENTTINEN, LEENA VEHMANEN, HANNU KAUTIAINEN, MARKKU KANKAANPÄÄ, RIKU NIKANDER and TIINA SAARTO

Anticancer Research June 2025, 45 (6) 2605-2618; DOI: https://doi.org/10.21873/anticanres.17632
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Tumor Budding Grade and T Stage as Recurrence Predictors of High-risk Stage II Colorectal Cancer
HIROYUKI KODAMA, TOSHIFUMI YAMAGUCHI, SHIN KAMEISHI, TORU KADONO, HIROKI YUKAMI, HIROKI HAMAMOTO, SANG-WOONG LEE and HIROKI NISHIKAWA

Anticancer Research June 2025, 45 (6) 2619-2628; DOI: https://doi.org/10.21873/anticanres.17633
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Machine Learning Model to Guide Empirical Antimicrobial Therapy in Febrile Neutropenic Patients With Hematologic Malignancies
KOSUKE HOASHI, KOUTAROU MATSUMOTO, JUNICHI KIYASU, TARO SAWABE, MAKOTO OYAMA, MARIKO TSUDA, AKIKO TAKAMATSU, ERIKO FUJIOKA, YUJI YUFU, MOTOAKI SHIRATSUCHI and KENTA MUROTANI

Anticancer Research June 2025, 45 (6) 2629-2642; DOI: https://doi.org/10.21873/anticanres.17634
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Correlation Between Body Mass Index and Clinical Outcomes in Advanced Renal Cell Carcinoma Patients
KENSUKE BEKKU, SHOTA INOUE, KASUMI YOSHINAGA, YOSUKE MITSUI, TOMOAKI YAMANOI, TATSUSHI KAWADA, YUSUKE TOMINAGA, TAKUYA SADAHIRA, SATOSHI KATAYAMA, TAKEHIRO IWATA, SHINGO NISHIMURA, KOHEI EDAMURA, TOMOKO KOBAYASHI and MOTOO ARAKI

Anticancer Research June 2025, 45 (6) 2643-2651; DOI: https://doi.org/10.21873/anticanres.17635
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Randomized Study of Short-time Continuous Saline Irrigation After Transurethral Resection in Non-muscle Invasive Bladder Cancer
TAKEHISA ONISHI, SHO SEKITO, TAKUJI SHIBAHARA and TADASHI YABANA

Anticancer Research June 2025, 45 (6) 2653-2660; DOI: https://doi.org/10.21873/anticanres.17636
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Effect of Monofilament Sutures on Incisional Hernia After Laparoscopic Colorectal Surgery: A Focus on Patients With Umbilical Hernia
HIROKAZU TANAKA, MASATO KITAZAWA, SATOSHI NAKAMURA, YUTA YAMAMOTO, SATORU MIYAZAKI, NAO HONDO, MASAHIRO KATAOKA, NAOKI ISHIZAKA, TADAAKI SHIMIZU, RYOHEI MIYASHITA and YUJI SOEJIMA

Anticancer Research June 2025, 45 (6) 2661-2668; DOI: https://doi.org/10.21873/anticanres.17637
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Intratumoral Injection of Allogeneic NK Cell With Chemotherapy in a Triple-negative Breast Cancer Preclinical Model
SA DEOK HONG, MIN SIL KANG, NAR BAHADUR KATUWAL, MITHUN GHOSH, NAHEE PARK, YOUNG BIN CHO, KAMAL PANDEY, AH-YOUNG KOWN, HEE JUNG AHN, SEUL-GI KIM, YOUNG SEOK BAEK, IN JEE LEE, SEUNG RYEOL LEE and YONG WHA MOON

Anticancer Research June 2025, 45 (6) 2669-2688; DOI: https://doi.org/10.21873/anticanres.17638
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A Case of Complete Response to ICI Therapy for Unresectable Esophageal Squamous Cell Carcinoma
KOSUKE KANEMITSU, YOSHIYUKI TAGAYASU, RIN YAMADA, MASAAKI IWATSUKI and YOSHIHIRO KOMOHARA

Anticancer Research June 2025, 45 (6) 2689-2695; DOI: https://doi.org/10.21873/anticanres.17639

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