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Table of Contents

June 2025; Volume 45,Issue 6

Reviews

  • Open Access
    De Novo Testicular Cancers Arising After Renal Transplantation: A Narrative Review
    LUCIO DELL’ATTI and VIKTORIA SLYUSAR
    Anticancer Research June 2025, 45 (6) 2239-2247; DOI: https://doi.org/10.21873/anticanres.17598
  • Open Access
    Mobile and Wireless Technologies for Gastrointestinal Cancer Treatment
    TORU AOYAMA, HARUHIKO CHO and KENTARO HARA
    Anticancer Research June 2025, 45 (6) 2249-2256; DOI: https://doi.org/10.21873/anticanres.17599

Experimental Studies

  • Open Access
    Selective Synergy of Ivermectin Combined With Recombinant Methioninase Against Colon-Cancer Cells in Contrast to Normal Fibroblasts
    YOHEI ASANO, QINGHONG HAN, SHUKUAN LI, KOHEI MIZUTA, BYUNG MO KANG, JIN SOO KIM, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, SEI MORINAGA, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN
    Anticancer Research June 2025, 45 (6) 2257-2263; DOI: https://doi.org/10.21873/anticanres.17600
  • Open Access
    Acyclic Retinoid Overcomes Vemurafenib Resistance in Melanoma Cells via Dual Inhibition of MAPK and PI3K/AKT/mTOR Pathways
    YUI SUZUKI, SOICHIRO USUKI, MITSUAKI NISHIZAWA, NORIYOSHI TANAKA, YOSHITOMO SUHARA and ICHIRO YAJIMA
    Anticancer Research June 2025, 45 (6) 2265-2278; DOI: https://doi.org/10.21873/anticanres.17601
  • Open Access
    Tumor Immunology Visualized in Realtime in In-vivo-like 3-D Gelfoam® Histoculture by Color-coded Imaging
    KOHEI MIZUTA, JOSE REYNOSO, YOHEI ASANO, BYUNG MO KANG, JIN SOO KIM, MICHAEL BOUVET, YASUNORI TOME, KOTARO NISHIDA and ROBERT M. HOFFMAN
    Anticancer Research June 2025, 45 (6) 2279-2283; DOI: https://doi.org/10.21873/anticanres.17602
  • Open Access
    Trametinib Synergized With Abemaciclib to Inhibit Tumor Growth in Human Head and Neck Squamous Cell Carcinoma Cells
    ERNEST DUAH, MING POI and JUNAN LI
    Anticancer Research June 2025, 45 (6) 2285-2295; DOI: https://doi.org/10.21873/anticanres.17603
  • Open Access
    Association of Interleukin-12A Genotypes With Nasopharyngeal Carcinoma Risk
    KAI-YUAN CHEN, CHE-LUN HSU, SHIH-WEI HSU, YEN-FANG LIU, YUN-CHI WANG, HOU-YU SHIH, WEN-SHIN CHANG, DA-TIAN BAU and CHIA-WEN TSAI
    Anticancer Research June 2025, 45 (6) 2297-2308; DOI: https://doi.org/10.21873/anticanres.17604
  • Open Access
    Role of the Circadian Clock Gene DEC1 in Chemosensitivity and Apoptosis in Colorectal Cancer
    SOICHIRO MINAMI, NORIKATSU MIYOSHI, SHIKI FUJINO, MASAYOSHI YASUI, MASAYUKI OHUE, MITSUNOBU TAKEDA, YUKI SEKIDO, TSUYOSHI HATA, ATSUSHI HAMABE, TAKAYUKI OGINO, MAMORU UEMURA, HIROFUMI YAMAMOTO, YUICHIRO DOKI and HIDETOSHI EGUCHI
    Anticancer Research June 2025, 45 (6) 2309-2328; DOI: https://doi.org/10.21873/anticanres.17605
  • You have access
    Enhanced DNA Double-strand Break Induction by Carbon Ions Under Intratumoral Hypoxia
    AKIKO ADACHI, TAKAHIRO OIKE, RYOSUKE KAMBE, YUKARI YOSHIDA, AKIHISA TAKAHASHI, YUKA HIROTA and TATSUYA OHNO
    Anticancer Research June 2025, 45 (6) 2329-2337; DOI: https://doi.org/10.21873/anticanres.17606
  • You have access
    Antitumor Activity of Ex Vivo Expanded Tumor Antigen Priming Cytotoxic T Cells Against Malignant Melanoma
    HOE-SUN YOON, YOUNG GYU PARK, DAE YOEN CHO, JONG-SEOK KIM and JONG GWON CHOI
    Anticancer Research June 2025, 45 (6) 2339-2350; DOI: https://doi.org/10.21873/anticanres.17607
  • You have access
    In Vitro Evaluation of the Dual Pharmacological Action of Vitamin D3 as Cardio-protectant and Anti-cancer Agent
    YESENIA L. FRANCO, HARDIK MODY and SIHEM AIT-OUDHIA
    Anticancer Research June 2025, 45 (6) 2351-2363; DOI: https://doi.org/10.21873/anticanres.17608
  • You have access
    Predictive Factors for Multiple Metastases of Clear-cell Renal Cell Carcinoma
    ANDREI-ALEXANDRU COSMA, ALINA GABRIELA NEGRU, OVIDIU CATALIN FERICIAN, MIHAELA MARIA PASCA FENESAN, VLAD VORNICU, ADELA MARIA FERICIAN, EUGEN MELNIC and ANCA MARIA CIMPEAN
    Anticancer Research June 2025, 45 (6) 2365-2375; DOI: https://doi.org/10.21873/anticanres.17609
  • You have access
    C-myc Oncogene Numerical Imbalances Analysis in Laryngeal Squamous Cell Carcinoma
    SOTIRIOS PAPOULIAKOS, VASILEIOS PAPANIKOLAOU, ARISTEIDIS CHRYSOVERGIS, EVANGELOS TSIAMBAS, DIMITRIOS ROUKAS, SOFIANIKI MASTRONIKOLI, GEORGE TSOUVELAS, GEORGE AGROGIANNIS, NIKOLAOS KAVANTZAS, VASILEIOS RAGOS, ANDREAS LAZARIS and EFTHYMIOS KYRODIMOS
    Anticancer Research June 2025, 45 (6) 2377-2383; DOI: https://doi.org/10.21873/anticanres.17610
  • You have access
    Immunogenicity of Neoantigens in Colorectal Cancer: Potential Influence of Tumor Mutation Burden, Stages, and Metastasis
    XIAOLIN YU, RYOUICHI TSUNEDOMI, SHOICHI HAZAMA, YUKI NAKAGAMI, SHINOBU TOMOCHIKA, MICHIHISA IIDA, TATSUYA IOKA, HIDENORI TAKAHASHI, KOJI TAMADA and HIROAKI NAGANO
    Anticancer Research June 2025, 45 (6) 2385-2399; DOI: https://doi.org/10.21873/anticanres.17611
  • You have access
    Tissue Prognostic Markers for Clear Cell Renal Cell Carcinoma Tumor-stroma Interaction: Impact on TNM Staging Parameters
    ANDREI ALEXANDRU COSMA, ALINA GABRIELA NEGRU, OVIDIU CATALIN FERICIAN, MIHAELA MARIA PASCA FENESAN, VLAD VORNICU, ADELA MARIA FERICIAN, EUGEN MELNIC and ANCA MARIA CIMPEAN
    Anticancer Research June 2025, 45 (6) 2401-2416; DOI: https://doi.org/10.21873/anticanres.17612
  • You have access
    The Role of EMP2 in Triple-negative Breast Cancer
    IN HEE LEE, EUN AE KIM, SOO JUNG LEE, BYEONGJU KANG, JEEYEON LEE, JIN HYANG JUNG, HO YONG PARK, JI-YOUNG PARK, NORA JEE-YOUNG PARK, JIEUN KANG and YEE SOO CHAE
    Anticancer Research June 2025, 45 (6) 2417-2427; DOI: https://doi.org/10.21873/anticanres.17613
  • You have access
    CA9-Positive Keloid Fibroblasts: Modulator of Local Inflammation Induced by the Hypoxic and Glycolysis-enhanced Microenvironment
    AIHUA GAO, ZHENLONG ZHENG, MI RYUNG ROH, GUOHUA ZHAO, MI YEON CHO, NA YEONG CHO, KEE YANG CHUNG, HAORAN XI and XIANGLAN ZHANG
    Anticancer Research June 2025, 45 (6) 2429-2442; DOI: https://doi.org/10.21873/anticanres.17614

Clinical Studies

  • Open Access
    Impact of Surgery Refusal on Overall Survival in Merkel Cell Carcinoma
    KYLE POPP, REED POPP, JADE BOWERS, SYEDA HOORULAIN AHMED, RAMIN SHEKOUHI, SHIVAM BANSAL, SEEMA SHARAN, HARSHEEN K. MANAISE, BANSI P. SAVALIY, SWATHI R. RAIKOT, PAOLA BERRIOS JIMENEZ, FATIMA MUBARAK, ESINAM P. EKPEH, KULKAEW B. SUKNIAM, GABRIELLE KOWKABANY, ANGEL AGUAYO and EMMANUEL M. GABRIEL
    Anticancer Research June 2025, 45 (6) 2443-2451; DOI: https://doi.org/10.21873/anticanres.17615
  • Open Access
    In-hospital Outcomes Between Total Parenteral Nutrition and Enteral Feeding in Esophageal and Gastric Cancer: A Nationwide Analysis
    SURIYA BASKAR, ROBERT SCHOENEICH and UDHAYVIR S. GREWAL
    Anticancer Research June 2025, 45 (6) 2453-2457; DOI: https://doi.org/10.21873/anticanres.17616
  • Open Access
    Liposarcomas of the Kidney and Surgical Management
    JACK D. SLEEMAN, JESSICA DELGADO, DANNY SLEEMAN, MARINA M. TABBARA and GAETANO CIANCIO
    Anticancer Research June 2025, 45 (6) 2459-2465; DOI: https://doi.org/10.21873/anticanres.17617
  • Open Access
    Gastrojejunostomy for Asymptomatic Gastric Outlet Obstruction in Pancreatic Cancer May Contribute to Early Recovery
    KATSUHISA HIRANO, ISAYA HASHIMOTO, NANA KIMURA, MINA FUKASAWA, RYO MURANUSHI, YOSHIHIRO SHIRAI, TORU WATANABE, KAZUTO SHIBUYA, ISAKU YOSHIOKA and TSUTOMU FUJII
    Anticancer Research June 2025, 45 (6) 2467-2476; DOI: https://doi.org/10.21873/anticanres.17618
  • Open Access
    Four Different Artificial Intelligence Models Versus Logistic Regression to Enhance the Diagnostic Accuracy of Fecal Immunochemical Test in the Detection of Colorectal Carcinoma in a Screening Setting
    MAARET ESKELINEN, TUOMAS SELANDER, DENISE PEIXOTO GUIMARÃES, KAI KAARNIRANTA, KARI SYRJÄNEN and MATTI ESKELINEN
    Anticancer Research June 2025, 45 (6) 2477-2491; DOI: https://doi.org/10.21873/anticanres.17619
  • You have access
    Pathological Investigation of Grasping-related Mesenteric Injury During Laparoscopic Colorectal Cancer Resection
    ATSUKO KATAOKA, TOMONORI KAWASAKI, KYOICHI KAIRA and YASUMITSU HIRANO
    Anticancer Research June 2025, 45 (6) 2493-2499; DOI: https://doi.org/10.21873/anticanres.17620
  • You have access
    Pathologic Complete Response (pCR) in Patient With Myxofibrosarcoma Who Underwent Neoadjuvant Radiation Concurrent to Complementary and Alternative Medicine
    GUSTAVO MIRANDA, MARWAN SHECKLEY, ROBERT R. KLEIN, ROBERT GIN, TOLGA TURKER and JENNIFER ERDRICH
    Anticancer Research June 2025, 45 (6) 2501-2505; DOI: https://doi.org/10.21873/anticanres.17621
  • You have access
    Association of County-level Social Determinants and Pancreatic Cancer Incidence in the United States
    KENNETH LUBERICE, MICHAEL C. CANTRELL, LAUREN EDGAR, CARMEN SMOTHERMAN, CHRISTINA GUERRIER, RAMZI G. SALLOUM, ALEXANDER S. PARKER, ERIN M. MOBLEY and ZIAD T. AWAD
    Anticancer Research June 2025, 45 (6) 2507-2514; DOI: https://doi.org/10.21873/anticanres.17622
  • Open Access
    Clinical Outcomes of Metastasis-directed Therapy for Oligo-metastatic Prostate Cancer Diagnosed Using PSMA-PET/CT or Whole-body MRI
    RIHITO AIZAWA, TAKASHI OGATA, TAKAYUKI GOTO, TOMOAKI OTANI, KIYONAO NAKAMURA, YUKI KITA, RYUSUKE NAKAMOTO, YOICHI SHIMIZU, TAKAYUKI SUMIYOSHI, KAORU MURAKAMI, KEI MIZUNO, TAKASHI KOBAYASHI, YUJI NAKAMOTO and TAKASHI MIZOWAKI
    Anticancer Research June 2025, 45 (6) 2515-2525; DOI: https://doi.org/10.21873/anticanres.17623
  • Open Access
    Efficacy and Treatment Outcomes of First-line Pazopanib Therapy in Advanced Renal Cell Carcinoma in Greece
    EVANGELOS BOURNAKIS, IOANNIS XANTHAKIS, MICHAIL VASLAMATZIS, PARISIS MAKRANTONAKIS, CHARISIOS KARANIKIOTIS, ILIAS ATHANASIADIS, ALEXANDROS ARDAVANIS, PAVLOS PAPAKOTOULAS, EPAMINONDAS SAMANTAS, CHRISTOS PAPANDREOU, MARIA MICHAILIDOU, PANAGIOTIS KATSAOUNIS and CHRISTOS CHRISTODOULOU
    Anticancer Research June 2025, 45 (6) 2527-2534; DOI: https://doi.org/10.21873/anticanres.17624
  • You have access
    End-of-life Androgen Deprivation Syndrome With Enzalutamide in Metastatic Prostate Cancer: A Case Report
    MINH DUNG NGUYEN, OLENA GOROBETS, YANNICK JOEL DJOUA, JOHAN ROSE-DITE-MODESTINE, VINCENT VINH-HUNG, CLAIRE VERSCHRAEGEN and NAM P. NGUYEN
    Anticancer Research June 2025, 45 (6) 2535-2538; DOI: https://doi.org/10.21873/anticanres.17625
  • You have access
    Phase II Study of the Effectiveness of the Germinated Wheat-derived Rigenase Plus Polyhexanide in the Prophylaxis for Hypofractionated Radiation-induced Acute Skin Toxicity in Breast Cancer
    VINCENZO IORIO, PIETRO DELIA, ANGELA PIA SOLAZZO, IVAN FAZIO, ANTONINO DAIDONE, ANDREA GIRLANDO, NICOLA DE ROSA, ALFIO DI GRAZIA, ANNALISA LA MACCHIA, SANTA BAMBACE, SALVATORE PARISI, CESARE GUIDA, MATTEO MUTO, VINCENZO CARFORA, MARIANGELA BOCCARDI, SALVATORE BONANNO, FRANCESCA DORIA, ALFONSINA PEPE, GIUSEPPE IATÌ, ANTONIO SPERA, GIANLUCA MORTELLARO, ALESSANDRO FANELLI, VINCENZO BARONE, PAOLO MUTO, MARIA ROSARIA VALERIO, GIUSEPPA SCANDURRA, DANIELA SAMBATARO, GRAZIA LAZZARI, MARIA ENFASI and VITTORIO GEBBIA
    Anticancer Research June 2025, 45 (6) 2539-2550; DOI: https://doi.org/10.21873/anticanres.17626
  • You have access
    Blood Concentrations of Osimertinib and Its Active Metabolites: Impact on Treatment Efficacy and Safety
    TAKAE OKUNO, MASAFUMI HONGOH, RYOSUKE TANINO, TAMIO OKIMOTO, YUKARI TSUBATA and TAKESHI ISOBE
    Anticancer Research June 2025, 45 (6) 2551-2561; DOI: https://doi.org/10.21873/anticanres.17627
  • You have access
    Efficacy of Pembrolizumab as Second or Third-line Therapy for Local Advanced and Metastatic Urothelial Cancer
    TOMOHIRO MATSUO, YASUYOSHI MIYATA, JUNKI HARADA, ITSUHO ITOH, TSUYOSHI MATSUDA, AKIHIRO ASAI, TSUBASA KONDO, HIROKI KURATA, SUZUNA SAKAI, HIDENORI ITOH, KENSUKE MITSUNARI and RYOICHI IMAMURA
    Anticancer Research June 2025, 45 (6) 2563-2573; DOI: https://doi.org/10.21873/anticanres.17628
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    Combined Biomarkers for Prediction of Immune Checkpoint Inhibitor Response in Patients With Triple-negative Breast Cancer
    HAN GYEOL KIM, SO YOUNG KANG, KYOUNG-MEE KIM, JI-YEON KIM, YEON HEE PARK, JIN SEOK AHN, YOUNG-HYUCK IM, YOOJOO LIM, SANGHOON SONG, KYUNGHYUN PAENG and EUN YOON CHO
    Anticancer Research June 2025, 45 (6) 2575-2586; DOI: https://doi.org/10.21873/anticanres.17629
  • You have access
    Effect of a Biweekly Dosing Schedule on Severe Neutropenia Induced by Trifluridine/Tipiracil in Colorectal Cancer
    YOSUKE ANDO, HANAHO ORITO, TOMOHIRO MIZUNO, HIDETOSHI KATSUNO, ZENICHI MORISE, AKIHIKO HORIGUCHI, HIROSHI MATSUOKA, KOICHI SUDA, TAKAHIRO HAYASHI and SHIGEKI YAMADA
    Anticancer Research June 2025, 45 (6) 2587-2594; DOI: https://doi.org/10.21873/anticanres.17630
  • You have access
    Prognostic Nutritional Index Is the Key Prognostic Factor in Elderly Patients With Colorectal Cancer
    YASUNOBU KOBAYASHI, YASUHIRO TAKANO, SAYA MATSUKIDA, TERUYUKI TAKISHIMA, WATARU KAI, SHU TSUKIHARA, DAISUKE ITO, HIRONORI KANNO, NOBUYOSHI HANYU and KEN ETO
    Anticancer Research June 2025, 45 (6) 2595-2603; DOI: https://doi.org/10.21873/anticanres.17631
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    Feasibility of an Exercise Training Program Among Patients With Newly Diagnosed Advanced Breast Cancer
    KRISTIINA KOKKONEN, MERI UTRIAINEN, HEIDI PENTTINEN, LEENA VEHMANEN, HANNU KAUTIAINEN, MARKKU KANKAANPÄÄ, RIKU NIKANDER and TIINA SAARTO
    Anticancer Research June 2025, 45 (6) 2605-2618; DOI: https://doi.org/10.21873/anticanres.17632
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    Tumor Budding Grade and T Stage as Recurrence Predictors of High-risk Stage II Colorectal Cancer
    HIROYUKI KODAMA, TOSHIFUMI YAMAGUCHI, SHIN KAMEISHI, TORU KADONO, HIROKI YUKAMI, HIROKI HAMAMOTO, SANG-WOONG LEE and HIROKI NISHIKAWA
    Anticancer Research June 2025, 45 (6) 2619-2628; DOI: https://doi.org/10.21873/anticanres.17633
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    Machine Learning Model to Guide Empirical Antimicrobial Therapy in Febrile Neutropenic Patients With Hematologic Malignancies
    KOSUKE HOASHI, KOUTAROU MATSUMOTO, JUNICHI KIYASU, TARO SAWABE, MAKOTO OYAMA, MARIKO TSUDA, AKIKO TAKAMATSU, ERIKO FUJIOKA, YUJI YUFU, MOTOAKI SHIRATSUCHI and KENTA MUROTANI
    Anticancer Research June 2025, 45 (6) 2629-2642; DOI: https://doi.org/10.21873/anticanres.17634
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    Correlation Between Body Mass Index and Clinical Outcomes in Advanced Renal Cell Carcinoma Patients
    KENSUKE BEKKU, SHOTA INOUE, KASUMI YOSHINAGA, YOSUKE MITSUI, TOMOAKI YAMANOI, TATSUSHI KAWADA, YUSUKE TOMINAGA, TAKUYA SADAHIRA, SATOSHI KATAYAMA, TAKEHIRO IWATA, SHINGO NISHIMURA, KOHEI EDAMURA, TOMOKO KOBAYASHI and MOTOO ARAKI
    Anticancer Research June 2025, 45 (6) 2643-2651; DOI: https://doi.org/10.21873/anticanres.17635
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    Randomized Study of Short-time Continuous Saline Irrigation After Transurethral Resection in Non-muscle Invasive Bladder Cancer
    TAKEHISA ONISHI, SHO SEKITO, TAKUJI SHIBAHARA and TADASHI YABANA
    Anticancer Research June 2025, 45 (6) 2653-2660; DOI: https://doi.org/10.21873/anticanres.17636
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    Effect of Monofilament Sutures on Incisional Hernia After Laparoscopic Colorectal Surgery: A Focus on Patients With Umbilical Hernia
    HIROKAZU TANAKA, MASATO KITAZAWA, SATOSHI NAKAMURA, YUTA YAMAMOTO, SATORU MIYAZAKI, NAO HONDO, MASAHIRO KATAOKA, NAOKI ISHIZAKA, TADAAKI SHIMIZU, RYOHEI MIYASHITA and YUJI SOEJIMA
    Anticancer Research June 2025, 45 (6) 2661-2668; DOI: https://doi.org/10.21873/anticanres.17637
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    Intratumoral Injection of Allogeneic NK Cell With Chemotherapy in a Triple-negative Breast Cancer Preclinical Model
    SA DEOK HONG, MIN SIL KANG, NAR BAHADUR KATUWAL, MITHUN GHOSH, NAHEE PARK, YOUNG BIN CHO, KAMAL PANDEY, AH-YOUNG KOWN, HEE JUNG AHN, SEUL-GI KIM, YOUNG SEOK BAEK, IN JEE LEE, SEUNG RYEOL LEE and YONG WHA MOON
    Anticancer Research June 2025, 45 (6) 2669-2688; DOI: https://doi.org/10.21873/anticanres.17638
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    A Case of Complete Response to ICI Therapy for Unresectable Esophageal Squamous Cell Carcinoma
    KOSUKE KANEMITSU, YOSHIYUKI TAGAYASU, RIN YAMADA, MASAAKI IWATSUKI and YOSHIHIRO KOMOHARA
    Anticancer Research June 2025, 45 (6) 2689-2695; DOI: https://doi.org/10.21873/anticanres.17639
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In this issue

Anticancer Research: 45 (6)
Anticancer Research
Vol. 45, Issue 6
June 2025
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)

Issue highlights

  • Role of the Circadian Clock Gene DEC1 in Chemosensitivity and Apoptosis in Colorectal Cancer
  • Selective Synergy of Ivermectin Combined With Recombinant Methioninase Against Colon-Cancer Cells in Contrast to Normal Fibroblasts
  • Trametinib Synergized With Abemaciclib to Inhibit Tumor Growth in Human Head and Neck Squamous Cell Carcinoma Cells
  • Gastrojejunostomy for Asymptomatic Gastric Outlet Obstruction in Pancreatic Cancer May Contribute to Early Recovery
  • Clinical Outcomes of Metastasis-directed Therapy for Oligo-metastatic Prostate Cancer Diagnosed Using PSMA-PET/CT or Whole-body MRI
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Role of Resveratrol in Prevention and Therapy of Cancer: Preclinical and Clinical Studies
The Association of Solar Ultraviolet B (UVB) with Reducing Risk of Cancer: Multifactorial Ecologic Analysis of Geographic Variation in Age-adjusted Cancer Mortality Rates
Epithelial−Mesenchymal Transition in EGFR-TKI Acquired Resistant Lung Adenocarcinoma
Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention
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