Anticancer Research: 45 (5)

May 2025; Volume 45,Issue 5

Experimental Studies

Open Access
Inhibition of Plasminogen Activator Inhibitor-1 (PAI-1) by Tiplaxtinin Reduces Aggressiveness of Cervical Carcinoma Cells
SARAH WEHBE, JULIA GALLWAS and CARSTEN GRÜNDKER

Anticancer Research May 2025, 45 (5) 1793-1805; DOI: https://doi.org/10.21873/anticanres.17559
Open Access
Expression of YAP1 and TAZ in Melanoma-, Bronchial- and Breast Carcinoma Brain Metastasis: Primary vs. Relapsed Tumors
JILL DICKE, LAURA HERO, SASKIA KUHL, ROLAND GOLDBRUNNER and MARCO TIMMER

Anticancer Research May 2025, 45 (5) 1807-1812; DOI: https://doi.org/10.21873/anticanres.17560
Open Access
Advantages and Disadvantages of Drug Combination Treatment: Riluzole, Metformin and Dexamethasone Effect on Glioblastoma Cell
JONATHAN KEUL, SWETLANA SPERLING, VEIT ROHDE and MILENA NINKOVIC

Anticancer Research May 2025, 45 (5) 1813-1823; DOI: https://doi.org/10.21873/anticanres.17561
Open Access
Ubiquitin-proteasome Pathway-linked Gene Signatures as Prognostic Indicators in Prostate Cancer
YASUO TAKASHIMA, KENGO YOSHII, MASAMI TANAKA and KEI TASHIRO

Anticancer Research May 2025, 45 (5) 1825-1841; DOI: https://doi.org/10.21873/anticanres.17562
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Potential Role of PTEN and AKT/PKB Proteins in the Pathogenesis of Ovarian Mature Teratomas
JAROSŁAW BAL, LUKASZ FULAWKA, MARIAN GABRYŚ, MAREK MURAWSKI and AGNIESZKA HALON

Anticancer Research May 2025, 45 (5) 1843-1851; DOI: https://doi.org/10.21873/anticanres.17563
Open Access
Combination of Recombinant Methioninase With Rapamycin or Chloroquine Is Synergistic to Highly Inhibit Triple-negative Breast Cancer Cells In Vitro
JINSOO KIM, QINGHONG HAN, BYUNG MO KANG, KOHEI MIZUTA, YOHEI ASANO, MICHAEL BOUVET and ROBERT M. HOFFMAN

Anticancer Research May 2025, 45 (5) 1853-1859; DOI: https://doi.org/10.21873/anticanres.17564
Open Access
Contribution of Methylenetetrahydrofolate Reductase Genotypes to Brain Tumor Risk Determination in Taiwan
CHAO-HSUAN CHEN, CHUN-CHUNG CHEN, XIAN-XIU CHEN, WEN-SHIN CHANG, CHIA-WEN TSAI, MEI-CHIN MONG, SHIH-WEI HSU and DA-TIAN BAU

Anticancer Research May 2025, 45 (5) 1861-1870; DOI: https://doi.org/10.21873/anticanres.17565
Open Access
Recombinant Methioninase and Cisplatinum Act Synergistically to Inhibit Lewis Lung Carcinoma Cells But Not Normal Fibroblasts
YOHEI ASANO, QINGHONG HAN, KOHEI MIZUTA, BYUNG MO KANG, JIN SOO KIM, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, SEI MORINAGA, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Anticancer Research May 2025, 45 (5) 1871-1876; DOI: https://doi.org/10.21873/anticanres.17566
Open Access
Development of Acquired Resistance in Alpelisib-treated Gastric Cancer Cells With PIK3CA Mutations and Overcoming Strategies
MINSU KANG, KUI-JIN KIM, JI HEA SUNG, MILANG NAM, SUNG-HYUN HWANG, WOOCHAN PARK, JEONGMIN SEO, EUN HEE JUNG, KOUNG JIN SUH, JI-WON KIM, SE HYUN KIM, JIN WON KIM, YU JUNG KIM, JEE HYUN KIM and KEUN-WOOK LEE

Anticancer Research May 2025, 45 (5) 1877-1896; DOI: https://doi.org/10.21873/anticanres.17567
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Correlation Analysis Between IFIT2 and HLA Class II in Oral Cancer
KUO-CHU LAI, CHI-WEI CHEN, PETER MU-HSIN CHANG, YI-CHUN LIAO, CHUANG-WEI WANG, CHIA-HSUN HSIEH and TSUNG-TENG HUANG

Anticancer Research May 2025, 45 (5) 1897-1914; DOI: https://doi.org/10.21873/anticanres.17568
Open Access
Elevated PD-L1 Expression on Circulating Classical Monocytes Upon Checkpoint Inhibitor Therapy Is Associated With Increased Plasma Interleukin 5 in Patients With Lung Cancer
EVA PROBST, CHRISTIAN IDEL, JONAS FLECKNER, KIRSTIN PLÖTZE-MARTIN, DIRK RADES, SABINE BOHNET, DANIEL DRÖMANN, KARL-LUDWIG BRUCHHAGE, KLAAS FRANZEN and RALPH PRIES

Anticancer Research May 2025, 45 (5) 1915-1925; DOI: https://doi.org/10.21873/anticanres.17569
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Role of Platelet Interactions in Promoting Melanoma Malignancy With Insights into Proliferation, Cyclin D1 Expression, and Migration
NORIKO YOSHIKAWA, CHINAMI IKUSHIMA, NANAKO TANAKA, ERIKO IWATA and KAZUKI NAKAMURA

Anticancer Research May 2025, 45 (5) 1927-1934; DOI: https://doi.org/10.21873/anticanres.17570
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Epigallocatechin Gallate Induces miR-192/215 Suppression of EGR1 in Gastric Cancer
NAN ZHOU, YUAN YUAN, HUIJUAN LIN, JIAN WANG, HUAN LIN, HASSAN ASHKTORAB, DUANE SMOOT, ZHE JIN, SHUTONG ZHUANG and YING QIN

Anticancer Research May 2025, 45 (5) 1935-1951; DOI: https://doi.org/10.21873/anticanres.17571
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Light Bladder Net: Non-invasive Bladder Cancer Prediction by Weighted Deep Learning Approaches and Graphical Data Transformation
CHI-HUA TUNG, SHIH-HUAN LIN, KAI-PO CHANG, YA-WEN XU, MIN-LING CHUANG and YEN-WEI CHU

Anticancer Research May 2025, 45 (5) 1953-1964; DOI: https://doi.org/10.21873/anticanres.17572
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SH003 Inhibits Proliferation and Induces Apoptosis in Colon Cancer Through the RTK-STAT3 Pathway
HYUN-HA HWANG, JI-SUNG YOO, JEONG-HUI JE, HYEONG-CHAN LEE, TAE HUN KIM, YUN-BEOM SIM, KWANG-JIN CHO, SUNG-GOOK CHO, CHUNHOO CHEON and SEONG-GYU KO

Anticancer Research May 2025, 45 (5) 1965-1980; DOI: https://doi.org/10.21873/anticanres.17573
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SH003 Inhibits Proliferation and Induces Apoptosis in NSCLC Cell Lines by Inhibiting the Receptor Tyrosine Kinase-related Pathway
HYUN-HA HWANG, JI-SUNG YOO, JEONG-HUI JE, HYEONG-CHAN LEE, TAE HUN KIM, YUN-BEOM SIM, KWANG-JIN CHO, TAEHYOUN KIM, SUNG-GOOK CHO and SEONG-GYU KO

Anticancer Research May 2025, 45 (5) 1981-1995; DOI: https://doi.org/10.21873/anticanres.17574
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High Expression of OR1F1 Protein as a Potential Prognostic Biomarker for Esophageal Squamous Cell Carcinoma
SHUNSUKE YAMAGISHI, MITSURO KANDA, TAKAHIRO SHINOZUKA, YUSUKE SATO, DAI SHIMIZU, CHIE TANAKA, SHINICHI UMEDA, HARUYOSHI TANAKA, HIDEKI TAKAMI, NORIFUMI HATTORI, MASAMICHI HAYASHI, GORO NAKAYAMA, YASUHIRO KODERA and YUKIYASU OKAMURA

Anticancer Research May 2025, 45 (5) 1997-2009; DOI: https://doi.org/10.21873/anticanres.17575
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MAP17 as a Mediator of HGF-induced Proliferation and Invasion in Gastric Cancer
BYEONG IL JANG, JI YOON JUNG, SUNG AE KOH, YONG-EUN PARK and KYUNG HEE LEE

Anticancer Research May 2025, 45 (5) 2011-2024; DOI: https://doi.org/10.21873/anticanres.17576

Clinical Studies

Open Access
Long-term Outcomes of Helical Tomotherapy in Lymph Node-positive Breast Cancer Following Breast-conserving Surgery
FELIX ZWICKER, LUIS-PHILIPP RAETHER, RUDOLF KLEPPER, HENRIK HAUSWALD, SEBASTIAN HOEFEL, PETER E. HUBER, JUERGEN DEBUS and MICHAEL SCHEMPP

Anticancer Research May 2025, 45 (5) 2025-2040; DOI: https://doi.org/10.21873/anticanres.17577
Open Access
Role of Stromal CD25+/CD8+ Lymphocyte Ratio in Patients With Grade 2-3 Cervical Intraepithelial Neoplasia (CIN 2-3): A Retrospective Single-center Study
ENRICO SIMONETTI, SABINA PISTOLESI, AMERIGO FERRARI, MATTEO DELLA ROSA, FEDERICA MEI, FEDERICO DI COCCO, FABIO TAPONECO, STEFANIA COSIO, ALESSANDRO BONUCCELLI, ANGIOLO GADDUCCI, TOMMASO SIMONCINI, PIETRO BOTTONE, ANTONIO GIUSEPPE NACCARATO and LAVINIA DOMENICI

Anticancer Research May 2025, 45 (5) 2041-2050; DOI: https://doi.org/10.21873/anticanres.17578
Open Access
Efficacy of Esophagectomy Following Neoadjuvant Chemotherapy for Esophageal Neuroendocrine Carcinoma
TAKESHI YAMASHITA, KOICHIRO FUJIMASA, KOJI OTSUKA, AKIRA SAITO, MASAHIRO KOHMOTO, KENTARO MOTEGI, TOMOTAKE ARIYOSHI, SATORU GOTO, TOSHIKO YAMOCHI, MASAFUMI TAKIMOTO, YUYA HIRASAWA, YUTARO KUBOTA, KIYOSHI YOSHIMURA, TAKUYA TSUNODA, MASAHIKO MURAKAMI and TAKESHI AOKI

Anticancer Research May 2025, 45 (5) 2051-2058; DOI: https://doi.org/10.21873/anticanres.17579
Open Access
Sex-related Survival Differences in Patients With Glioblastoma – Results From a Retrospective Analysis
JAN LEPPERT, CLAUDIA DITZ, JAKOB MATSCHKE, HARALD KRENZLIN, NAUREEN KERIC, CHRISTIAN ZIEMANN, LORENZ HAHN, MARIA VITTORIA MATONE, LARYSA LIUBICH, KAROLIN STREUBEL, HANNES SCHACHT, CHRISTINA HILLBRICHT, PATRICK KUPPLER, DIRK RADES and ANASTASSIA LÖSER

Anticancer Research May 2025, 45 (5) 2059-2069; DOI: https://doi.org/10.21873/anticanres.17580
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Efficacy and Prognostic Factors of Surgical Resection for Pulmonary Metastases From Ovarian Cancer
YO TSUKAMOTO, TAKASHI OHTSUKA, YOSHIKANE YAMAUCHI, MINGYON MUN, HARUHISA MATSUGUMA, HIROSHI HASHIMOTO, HIROKI FUKUDA, ICHIRO YOSIHNO, YASUSHI SHINTANI and MASAFUMI KAWAMURA

Anticancer Research May 2025, 45 (5) 2071-2078; DOI: https://doi.org/10.21873/anticanres.17581
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HOX-PBX Up-regulation Predicts Favorable Prognosis in NPM1-mutated Normal Cytogenetic AML via WNT Signaling
GHALEB ELYAMANY, SULTAN ALOTAIBI, BANDER ALHARBI, OSAMA ATALLAH ALHAFI, HASSAN ALJASEM, HADI JAMIL, TARIQ M. ROSHAN, ARIZ AKHTER and ADNAN MANSOOR

Anticancer Research May 2025, 45 (5) 2079-2089; DOI: https://doi.org/10.21873/anticanres.17582
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Impact of Nivolumab Plus Chemotherapy on Conversion Therapy in Clinical Stage IVB HER2-negative Gastric Cancer
YUDAI HOJO, TOSHIHIKO TOMITA, MASATAKA IGETA, MOTOKI MURAKAMI, SHUGO KOHNO, EIICHIRO NAKAO, YOSHITAKA KITAYAMA, TATSURO NAKAMURA, YASUNORI KURAHASHI, YOSHINORI ISHIDA, SEIICHI HIROTA, SHINICHIRO SHINZAKI and HISASHI SHINOHARA

Anticancer Research May 2025, 45 (5) 2091-2102; DOI: https://doi.org/10.21873/anticanres.17583
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Palliative Radiotherapy for Large Osteolytic Metastatic Tumors Involving the Iliac Bone: A Report of 16 Cases
FEDERICO AMPIL, RUSSELL ANDERSON, TROY RICHARDS, CARRIE PORTER and MICHELLE NORTON

Anticancer Research May 2025, 45 (5) 2103-2108; DOI: https://doi.org/10.21873/anticanres.17584
Open Access
Rare Upper Mediastinal Oligometastasis from Early Esophagogastric Adenocarcinoma: A Case Report
LARRY WENG-HONG LAI, TAKESHI YAMASHITA, KOJI OTSUKA, AKIRA SAITO, MASAHIRO KOHMOTO, KENTARO MOTEGI, TOMOTAKE ARIYOSHI, SATORU GOTO, MASAHIKO MURAKAMI and TAKESHI AOKI

Anticancer Research May 2025, 45 (5) 2109-2114; DOI: https://doi.org/10.21873/anticanres.17585
Open Access
Two Scoring Tools to Estimate the Risk of Taxane-induced Peripheral Sensory Neuropathy (PNP) in Patients Irradiated for Non-metastatic Breast Cancer
DIRK RADES, TOBIAS BARTSCHT, ACHIM RODY and MARTIN BALLEGAARD

Anticancer Research May 2025, 45 (5) 2115-2121; DOI: https://doi.org/10.21873/anticanres.17586
Open Access
Chemotherapy-induced Moderate to Severe Peripheral Neuropathy in Patients Receiving Adjuvant Radiotherapy for Breast Cancer
DIRK RADES, TOBIAS BARTSCHT, ACHIM RODY, NATHAN Y. YU and MARTIN BALLEGAARD

Anticancer Research May 2025, 45 (5) 2123-2135; DOI: https://doi.org/10.21873/anticanres.17587
Open Access
Radiomics for Growth Prediction of Vestibular Schwannomas in Neurofibromatosis Type 2
NINA BOE, VICTOR F. MAUTNER, REINHARD E. FRIEDRICH, SAID C. FARSCHTSCHI, LASSE DÜHRSEN, HANNO S. MEYER and JOHANNES A. KOEPPEN

Anticancer Research May 2025, 45 (5) 2137-2146; DOI: https://doi.org/10.21873/anticanres.17588
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Survival and Chemotherapy in the Last 30 Days as a Quality Indicator for Pancreatic Cancer
MINA M. SOLHEIM, CARSTEN NIEDER and ELLINOR C. HAUKLAND

Anticancer Research May 2025, 45 (5) 2147-2159; DOI: https://doi.org/10.21873/anticanres.17589
Open Access
The Impact of State-trait Anxiety Inventory (STAI) Self-evaluation versus 25-year Outcome: A Prospective Follow-up Study in Patients With Breast Cancer Symptoms
MATTI ESKELINEN, RIIKA KOSKELA, TUOMAS SELANDER, KAI KAARNIRANTA, PAULA OLLONEN and MAARET ESKELINEN

Anticancer Research May 2025, 45 (5) 2161-2169; DOI: https://doi.org/10.21873/anticanres.17590
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Prediction of Severe Anemia and Neutropenia Induced by Abemaciclib in Patients With Breast Cancer
SHINYA TAKADA, KENGO UMEHARA, TAHATSU KANAE, YUTA KIMURA, FUKAI YUTA, MITSUGU YAMAMOTO, NOBUMOTO TOMIOKA, KENICHI WATANABE and HASHISHITA HIROKAZU

Anticancer Research May 2025, 45 (5) 2171-2183; DOI: https://doi.org/10.21873/anticanres.17591
Open Access
Treatment Outcomes After Progression With Enfortumab Vedotin in Patients With Advanced Urothelial Carcinoma
NOBUKI FURUBAYASHI, MANABU MOCHIDA, ATSUHIRO KIJIMA, YUSHI FUJIMOTO, MOTONOBU NAKAMURA and TAKAHITO NEGISHI

Anticancer Research May 2025, 45 (5) 2185-2193; DOI: https://doi.org/10.21873/anticanres.17592
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Comparison of BRCA2 Single Nucleotide Variants Between Japanese Patients With Familial Prostate Cancer, Sporadic Prostate Cancer, and Benign Prostatic Hyperplasia
MASANORI AOKI, HIROSHI MATSUI, SOTA KURIHARA, NOBUAKI OHTAKE, SHUN NAKAZAWA, YUSUKE TSUJI, YUJI FUJIZUKA, SEIJI ARAI, MASASHI NOMURA, YOSHITAKA SEKINE, HIDEKAZU KOIKE, KAZUHIRO SUZUKI and YOSHIYUKI MIYAZAWA

Anticancer Research May 2025, 45 (5) 2195-2204; DOI: https://doi.org/10.21873/anticanres.17593
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Appendectomy Mitigates Ulcerative Colitis Activity and Delays Colorectal Cancer Onset: A Retrospective Cohort Study
YUSUKE IZUTANI, TAKAYUKI OGINO, MAKOTO FUJII, YUKI SEKIDO, NORIKATSU MIYOSHI, MAMORU UEMURA, TSUNEKAZU MIZUSHIMA, HIROAKI ITO, YUICHIRO DOKI and HIDETOSHI EGUCHI

Anticancer Research May 2025, 45 (5) 2205-2214; DOI: https://doi.org/10.21873/anticanres.17594
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Immune Checkpoint Inhibitor-induced Uveitis: Disproportionality and Timing Analyses of the Japanese Pharmacovigilance Database
NAOHITO IDE, KEN-ICHI SAKO and TOMOJI MAEDA

Anticancer Research May 2025, 45 (5) 2215-2223; DOI: https://doi.org/10.21873/anticanres.17595
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The Long-term Outcomes of Borderline Resectable T3 in Locally Advanced Esophageal Squamous Cell Carcinoma Treated With Neoadjuvant Triplet Chemotherapy
JUNYA KITADANI, KEIJI HAYATA, TARO GODA, SHINTA TOMINAGA, NAOKI FUKUDA, TOMOKI NAKAI, SHOTARO NAGANO and MANABU KAWAI

Anticancer Research May 2025, 45 (5) 2225-2235; DOI: https://doi.org/10.21873/anticanres.17596

Corrigendum

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Corrigendum
Anticancer Research May 2025, 45 (5) 2237; DOI: https://doi.org/10.21873/anticanres.17597

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