Neoadjuvant Chemoradiotherapy Enhances Tumor PD-L1 Expression in Pancreatic Cancer

KANECHIKA DEN; TAKASHI MURAKAMI; RYUSEI MATSUYAMA; KENTARO MIYAKE; YUKI HOMMA; YASUHIRO YABUSHITA; RYUTARO MORI; YUKIHIKO HIROSHIMA; IKUMA KATO; ITARU ENDO

doi:10.21873/anticanres.17554

Research ArticleClinical Studies

Neoadjuvant Chemoradiotherapy Enhances Tumor PD-L1 Expression in Pancreatic Cancer

KANECHIKA DEN, TAKASHI MURAKAMI, RYUSEI MATSUYAMA, KENTARO MIYAKE, YUKI HOMMA, YASUHIRO YABUSHITA, RYUTARO MORI, YUKIHIKO HIROSHIMA, IKUMA KATO and ITARU ENDO

Anticancer Research April 2025, 45 (4) 1731-1747; DOI: https://doi.org/10.21873/anticanres.17554

KANECHIKA DEN

1Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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TAKASHI MURAKAMI

1Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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RYUSEI MATSUYAMA

1Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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KENTARO MIYAKE

1Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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YUKI HOMMA

1Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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YASUHIRO YABUSHITA

1Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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RYUTARO MORI

1Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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YUKIHIKO HIROSHIMA

2Department of Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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IKUMA KATO

3Department of Molecular Pathology, Yokohama City University School of Medicine, Yokohama, Japan

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ITARU ENDO

1Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan;

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For correspondence: endoit{at}yokohama-cu.ac.jp

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Neoadjuvant Chemoradiotherapy Enhances Tumor PD-L1 Expression in Pancreatic Cancer

KANECHIKA DEN, TAKASHI MURAKAMI, RYUSEI MATSUYAMA, KENTARO MIYAKE, YUKI HOMMA, YASUHIRO YABUSHITA, RYUTARO MORI, YUKIHIKO HIROSHIMA, IKUMA KATO, ITARU ENDO

Anticancer Research Apr 2025, 45 (4) 1731-1747; DOI: 10.21873/anticanres.17554

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Neoadjuvant Chemoradiotherapy Enhances Tumor PD-L1 Expression in Pancreatic Cancer

KANECHIKA DEN, TAKASHI MURAKAMI, RYUSEI MATSUYAMA, KENTARO MIYAKE, YUKI HOMMA, YASUHIRO YABUSHITA, RYUTARO MORI, YUKIHIKO HIROSHIMA, IKUMA KATO, ITARU ENDO

Anticancer Research Apr 2025, 45 (4) 1731-1747; DOI: 10.21873/anticanres.17554

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Identification of Small Molecule Inhibitors Targeting PD-L1 Protein Using Computational Tools and an Experimental Assay

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Keywords

Pancreatic cancer
neoadjuvant chemoradiotherapy
PD-1
PD-L1
tumor-infiltrating lymphocyte

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