Anticancer Research: 45 (2)

February 2025; Volume 45,Issue 2

Review

Open Access
The Impact of AI-driven Remote Patient Monitoring on Cancer Care: A Systematic Review
FAYHA AZIZ, DILETTA BIANCHINI, DAVID B. OLAWADE and STERGIOS BOUSSIOS

Anticancer Research February 2025, 45 (2) 407-418; DOI: https://doi.org/10.21873/anticanres.17430

Experimental Studies

Open Access
Noncancerous Exosomes Establish a Growth Promoting Paracrine Effect on Triple Negative Breast Cancer Cells
LETITIA A. YEARBY, MANASA KOTINA, AFIA OHEMENG, BIPIKA BANJARA, MOUNIKA PAMUKUNTLA, PAIGE ROBERTS, JASMINE JOHNSON, KAITLYN PERKINS, JOSIAH OCHIENG, JILLIAN L. POPE, SYREETA L. TILGHMAN and KITANI PARKER LEMIEUX

Anticancer Research February 2025, 45 (2) 419-431; DOI: https://doi.org/10.21873/anticanres.17431
Open Access
Acyclic Retinoid Inhibits the EGFR/AKT Signaling Pathway and Cancels Cisplatin-resistant Cell Characteristics
MAKITO MOTOYAMA, RYOTA SHIGEFUKU, NORIYOSHI TANAKA, MITSUAKI NISHIZAWA, KEIGO OSHIO, YOSHITOMO SUHARA and ICHIRO YAJIMA

Anticancer Research February 2025, 45 (2) 433-443; DOI: https://doi.org/10.21873/anticanres.17432
Open Access
Correlation of HLA-A and HLA-B/C Expression With ESR1 Expression in Patients With Metastatic Breast Cancer as a Potential Prognosticator of Favorable Distant Disease-free Survival
LUKAS GOERDT, ALEKSANDRA STEFANOVIC, RALPH WIRTZ, UROS KARIC, THOMAS M. DEUTSCH, MAXIMILIAN KOHLER, ANDREAS SCHNEEWEISS, MARC SÜTTERLIN, STEFAN STEFANOVIC, JAN HOFMANN and MARKUS WALLWIENER

Anticancer Research February 2025, 45 (2) 445-450; DOI: https://doi.org/10.21873/anticanres.17433
Open Access
Recombinant Methioninase (rMETase) Synergistically Sensitizes Ivermectin-resistant MCF-7 Breast Cancer Cells 9.9 Fold to Low-dose Ivermectin
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG MO KANG, CHIHIRO HOZUMI, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

Anticancer Research February 2025, 45 (2) 451-455; DOI: https://doi.org/10.21873/anticanres.17434
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Synthesis of Polymethoxylated 3-Styrylflavones and their Antiproliferative Activity in HL60 Cells
ARISA TSUTSUMI, SATORU KAWAII and YUKO YOSHIZAWA

Anticancer Research February 2025, 45 (2) 457-464; DOI: https://doi.org/10.21873/anticanres.17435
Open Access
Association of Matrix Metalloproteinase-1 Promoter Genotypes With Endometriosis Risk
PO-CHUEN SHIEH, HOU-YU SHIH, CHIN-LIANG CHUANG, CHIA-WEN TSAI, WEN-SHIN CHANG, MENG-GI BAU, YUN-CHI WANG, TE-CHUN HSIA, DA-TIAN BAU and JAI-SING YANG

Anticancer Research February 2025, 45 (2) 465-471; DOI: https://doi.org/10.21873/anticanres.17436
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MiR-5586-5p Suppresses Hypoxia-induced Angiogenesis Through Multiple Targeting of HIF-1α, HBEGF and ADAM17 in Breast Cancer
DONGJO SHIN, JE-OK YOO, JAE-HOON JEONG and YOUNG-HOON HAN

Anticancer Research February 2025, 45 (2) 473-489; DOI: https://doi.org/10.21873/anticanres.17437
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Adjusting Treatment Strategies Using Circulating Tumor Cells: Preliminary Results on Metastatic Colorectal Cancer
JOACHIM DREVS, MANDEEP SINGH MALHOTRA, HUSEYIN SAHINBAS, AGGELOS ILIOPOULOS, GEORGE BEIS, PANAGIOTIS APOSTOLOU and IOANNIS PAPASOTIRIOU

Anticancer Research February 2025, 45 (2) 491-502; DOI: https://doi.org/10.21873/anticanres.17438
Open Access
Anti-tumor Effects of Erlotinib via Thymidylate Synthase Down-regulation in Pancreatic Cancer Cells
SATOSHI TABUCHI, TETSURO TOMINAGA, TOMOSHI TSUCHIYA, RYOICHIRO DOI, JYUNICHI ARAI, TAKASHI NONAKA, TAKURO MIYAZAKI, TATSUO INAMINE, KAZUHIRO TSUKAMOTO and KEITARO MATSUMOTO

Anticancer Research February 2025, 45 (2) 503-510; DOI: https://doi.org/10.21873/anticanres.17439
Open Access
Pterostilbene Suppressed Cell Viability, Induced Apoptosis and Autophagy of Cisplatin-resistant Gastric Cancer Cells
CHIEN-JUNG HUANG, PO-CHUEN SHIEH, JAI-SING YANG, YI-CHIA LI, YU-JEN CHIU, DA-TIAN BAU and CHIH-HSIN HUNG

Anticancer Research February 2025, 45 (2) 511-523; DOI: https://doi.org/10.21873/anticanres.17440
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Immunosuppressive State May Lead to Brain Metastases in Lung Squamous Cell Carcinoma: Gene Expression and Immunohistochemical Analysis
YOUNG WHA KOH, JAE-HO HAN, SEOKJIN HAAM and HYUN WOO LEE

Anticancer Research February 2025, 45 (2) 525-534; DOI: https://doi.org/10.21873/anticanres.17441
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A New PD-L1 Nanobody Enhances Cell Death in Lung Cancer In Vitro and In Vivo
XIAO-TONG TAN, SHI-WEI HUANG, YU-CHUAN LIN, FANG-YU LIN, DER-YANG CHO and SHAO-CHIH CHIU

Anticancer Research February 2025, 45 (2) 535-547; DOI: https://doi.org/10.21873/anticanres.17442
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PRPF4 Knockdown Suppresses Glioblastoma Progression via the p38 MAPK and ERK Signaling Pathways
WANSOO KIM, SONG PARK, SE-HYEON HAN, HEE-YEON KIM, SEOUNG-WOO LEE, DAEHWAN KIM, SOYOUNG JANG, JIN-KYU PARK, JEE EUN HAN, CHOONOK KIM, JAELIM CHO, ETHAN SEAH, JIYEON LEE, ZAE YOUNG RYOO and SEONG-KYOON CHOI

Anticancer Research February 2025, 45 (2) 549-564; DOI: https://doi.org/10.21873/anticanres.17443
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Camptothecin Triggers Apoptosis in Human and Mouse Drug-resistant Glioblastoma Cells via ROS-mediated Activation of the p53-p21-CD1/CDK2-E2F1-Bcl-xL Signaling Axis
GONG-JHE WU, JUI-TAI CHEN, YIH-GIUN CHERNG, CHIEN-JU LIN, SHING-HWA LIU and RUEI-MING CHEN

Anticancer Research February 2025, 45 (2) 565-577; DOI: https://doi.org/10.21873/anticanres.17444
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Characterization of Patient-derived Xenograft Models of Liver Fluke-associated Cholangiocarcinoma: From Establishment to Molecular Profiling
HASAYA DOKDUANG, APIWAT JARERNRAT, ATTAPOL TITAPUN, SIRINYA SITTHIRAK, SUREERAT PADTHAISONG, YINGPINYAPT KITTIRAT, SAKKARN SANGKAMANON, PRAKASIT SA-NGIAMWIBOOL, ARPORN WANGWIWATSIN, PORAMATE KLANRIT, NISANA NAMWAT, APINYA JUSAKUL, YOSHINORI MURAKAMI and WATCHARIN LOILOME

Anticancer Research February 2025, 45 (2) 579-592; DOI: https://doi.org/10.21873/anticanres.17445
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Computational Exploration of a Diverse Flavonoid Library for Targeted Allosteric Inhibition of AKT1 in Cancer Therapy
MOHD REHAN, ISHFAQ A. SHEIKH, MOHD SUHAIL, SHAMS TABREZ and SHAZI SHAKIL

Anticancer Research February 2025, 45 (2) 593-604; DOI: https://doi.org/10.21873/anticanres.17446

Clinical Studies

Open Access
Paired Comparison of Whole Genome Sequencing and Comprehensive Targeted Sequencing of Pancreatic Cancer Tissue
THEA AMALIE HVIDTFELDT, TIM SVENSTRUP POULSEN, INNA MARKOVNA CHEN, LOUISE LAURBERG KLARSKOV and ESTRID HØGDALL

Anticancer Research February 2025, 45 (2) 605-612; DOI: https://doi.org/10.21873/anticanres.17447
Open Access
Unusual Presentation of Advanced Urothelial Cancer in a Young Patient
DANIELA GUEVARA, NARA SHIN, ALEXANDRA BOIKO, IVAN VALIEV, AHMED G. ELSAEED, JUAN MIGUEL MOSQUERA, MAJD AL ASSAAD, JYOTHI MANOHAR, MICHAEL SIGOUROS, ALISA ZAICHIKOVA, VICTORIA FOMCHENKOVA, LEYSAN YUNUSOVA, SOFIA SMIRNOVA, OLIVIER ELEMENTO, DAVID NANUS and CORA N. STERNBERG

Anticancer Research February 2025, 45 (2) 613-618; DOI: https://doi.org/10.21873/anticanres.17448
Open Access
Mesonephric Adenocarcinoma in a Young Male Patient
DANIELA GUEVARA, NARA SHIN, ALEXANDRA BOIKO, IVAN VALIEV, AHMED G. ELSAEED, JUAN MIGUEL MOSQUERA, MAJD AL ASSAAD, JYOTHI MANOHAR, MICHAEL SIGOUROS, ALISA ZAICHIKOVA, VICTORIA FOMCHENKOVA, LEYSAN YUNUSOVA, SOFIA SMIRNOVA, OLIVIER ELEMENTO, JONES NAUSEEF and CORA N. STERNBERG

Anticancer Research February 2025, 45 (2) 619-623; DOI: https://doi.org/10.21873/anticanres.17449
Open Access
Cyclin E Expression and p16 Loss Are Strong Prognostic Biomarkers in Primary Invasive Cutaneous Melanoma
IOANNIS G. GKIONIS, MARIA TZARDI, ATHANASIOS ALEGAKIS, GALATEIA DATSERI, ELENI MOUSTOU, GEORGIOS SARIDAKIS, DIMOSTHENIS MICHELAKIS, SABINE KRUGER-KRASAGAKIS, KONSTANTINOS KRASAGAKIS and EELCO DE BREE

Anticancer Research February 2025, 45 (2) 625-637; DOI: https://doi.org/10.21873/anticanres.17450
Open Access
Efficacy of Second-line Nivolumab Versus Tyrosine Kinase Inhibitors for Renal Cell Carcinoma With Bone Metastases
GAKU YAMAMICHI, TAIGO KATO, AKIHIRO YOSHIMURA, MASARU TANI, YUKI HORIBE, YUTONG LIU, NESRINE SASSI, YOHEI OKUDA, TOSHIKI OKA, TOSHIHIRO UEMURA, AKINARU YAMAMOTO, YU ISHIZUYA, TAKUJI HAYASHI, YOSHIYUKI YAMAMOTO, KOJI HATANO, ATSUNARI KAWASHIMA, TETSUYA TAKAO, KENSAKU NISHIMURA, SHINGO TAKADA, MASAO TSUJIHATA and NORIO NONOMURA

Anticancer Research February 2025, 45 (2) 639-650; DOI: https://doi.org/10.21873/anticanres.17451
Open Access
Clinical Impact of Cellular Senescence and RNA Dysregulation in HCC Is Associated With MASLD and HCV-SVR
SHOTARO MIYASHITA, TAKAYUKI SHIMIZU, MAIKO NIKI, SHUN SATO, GENKI TANAKA, TAKAMUNE YAMAGUCHI, KWANG HWA PARK, TAKATSUGU MATSUMOTO, TAKAYUKI SHIRAKI, SHOZO MORI and TAKU AOKI

Anticancer Research February 2025, 45 (2) 651-659; DOI: https://doi.org/10.21873/anticanres.17452
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Use of Indocyanine Green Fluorescence Angiography to Assess Bowel Anastomosis in Ovarian Cancer Surgery
BEATRIZ NAVARRO SANTANA, OCTAVIO ARENCIBIA, GUILLAUME BABIN, EUDALDO TOMMASETTI, SARA FORTE, ALICIA MARTÍN MARTÍNEZ and FREDERIC GUYON

Anticancer Research February 2025, 45 (2) 661-666; DOI: https://doi.org/10.21873/anticanres.17453
Open Access
Free Interleukin 18 (IL-18F) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer
MAARET ESKELINEN, TUOMAS SELANDER, JUKKA PULKKINEN, KAI KAARNIRANTA, ESA HÄMÄLÄINEN and MATTI ESKELINEN

Anticancer Research February 2025, 45 (2) 667-675; DOI: https://doi.org/10.21873/anticanres.17454
Open Access
Prognostic Significance of the Detection of Human Papilloma Virus L1 Protein in Smears of Cervical Intraepithelial Neoplasia Grade 3 in Pregnant Women
FREDERIK A. STUEBS, ANNA K. DIETL, CARLA E. SCHULMEYER, ANNIKA S. BEHRENS, ANJA SEIBOLD, LENA BRUECKNER, OLIVER SCHLEICHER, WERNER ADLER, CAROL GEPPERT, ARNDT HARTMAN, ANTJE KNÖLL, MATTHIAS W. BECKMANN, PAUL GASS, RALF HILFRICH and GRIT MEHLHORN

Anticancer Research February 2025, 45 (2) 677-683; DOI: https://doi.org/10.21873/anticanres.17455
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Enhanced Potential of Durvalumab in the Initial Treatment of Advanced Biliary Tract Cancer
JUNGO YASUDA, HIRONORI SHIOZAKI, TARO SAKAMOTO, YASURO FUTAGAWA, TOMOYOSHI OKAMOTO and TORU IKEGAMI

Anticancer Research February 2025, 45 (2) 685-690; DOI: https://doi.org/10.21873/anticanres.17456
Open Access
Peak-postoperative Serum Transaminases Correlate With Post-hepatectomy Liver Failure and Inflow Occlusion After Laparoscopic Liver Resection
HAJIME KAMIYA, TAISUKE IMAMURA, HISASHI IKOMA, RYO MORIMURA, YUSUKE YAMAMOTO, JUN KIUCHI, KENJI NANISHI, HIROKI SHIMIZU, TOMOHIRO ARITA, HIROTAKA KONISHI, ATSUSHI SHIOZAKI, TAKESHI KUBOTA, HITOSHI FUJIWARA and EIGO OTSUJI

Anticancer Research February 2025, 45 (2) 691-700; DOI: https://doi.org/10.21873/anticanres.17457
Open Access
Bladder Volume <200 ml During a Course of Moderate Hypofractionated Irradiation in Patients With Localized Prostate Cancer
DIRK RADES, CHARLOTTE KRISTIANSEN, CHRISTINE VESTERGAARD MADSEN, JAN-DIRK KÜTER, LAURA SPLETTSTÖSSER, CATHRIN THIEME, JON CACICEDO and STEFAN JANSSEN

Anticancer Research February 2025, 45 (2) 701-708; DOI: https://doi.org/10.21873/anticanres.17458
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The Impact of Tonsillectomy on Oropharyngeal Cancer Development
SHIRRELL GLITZKY, ACHIM FRANZEN and ANNEKATRIN COORDES

Anticancer Research February 2025, 45 (2) 709-718; DOI: https://doi.org/10.21873/anticanres.17459
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Clinicopathological and Molecular Insights into Primary Retroperitoneal Squamous Cell Carcinoma: HPV Association and Discovery of Recurrent PIK3CA E545K Mutation
HAN GYEOL KIM, SUNG KYOUNG MOON, HYUN-SOO KIM and KIYONG NA

Anticancer Research February 2025, 45 (2) 719-731; DOI: https://doi.org/10.21873/anticanres.17460
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Efficacy and Safety of Amrubicin Monotherapy After Chemoradiotherapy in Patients With Relapsed Limited Disease Small-cell Lung Cancer
AKIRA MATSUKIDA, HISAO IMAI, AYAKO SHIONO, YASUHIRO RYUNO, KOSUKE HASHIMOTO, YU MIURA, SATOSHI ENDO, SHOHEI OKAZAKI, OU YAMAGUCHI, ATSUTO MOURI, TAKANORI ABE, KYOICHI KAIRA, KUNIHIKO KOBAYASHI, SHINGO KATO and HIROSHI KAGAMU

Anticancer Research February 2025, 45 (2) 733-741; DOI: https://doi.org/10.21873/anticanres.17461
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Negative Impact of Low Serum Cholinesterase on Short- and Long-term Outcomes in Elderly Patients Undergoing Scheduled Surgery for Colorectal Cancer
TERUYUKI TAKISHIMA, YASUNOBU KOBAYASHI, SAYA MATSUKIDA, WATARU KAI, YASUHIRO TAKANO, HIRONORI KANNO, TOSHIAKI MORIKAWA, NOBUYOSHI HANNYU and KEN ETO

Anticancer Research February 2025, 45 (2) 743-750; DOI: https://doi.org/10.21873/anticanres.17462
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Prognostic Stratification Using Early Prostate-specific Antigen Kinetics in Men With Metastatic Hormone-sensitive Prostate Cancer
TASUKU HIROSHIGE, HIROKI SUEKANE, TAKAHO TOKUNAGA, MAMI UEGAKI, MASAHITO IWASHITA, HIROKI TAURA, TAISHI HIRANO, TOMOTARO MITANI, MITSUNORI MATSUO and TSUKASA IGAWA

Anticancer Research February 2025, 45 (2) 751-759; DOI: https://doi.org/10.21873/anticanres.17463
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Ex Vivo Endocytoscopic Evaluation of Pancreatobiliary Cancers: A Step Toward Real-time In Vivo Diagnosis
SUGURU SASAMOTO, TAKESHI AOKI, YOSHIHIKO TASHIRO, KAZUHIRO MATSUDA, TATSUYA YAMAZAKI, HIROKI YAMAUE, JUN OHARA, MAYUMI HOMMA, MASAFUMI TAKIMOTO and TOSHIKO YAMOCHI

Anticancer Research February 2025, 45 (2) 761-771; DOI: https://doi.org/10.21873/anticanres.17464
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Prognostic Significance of Splenic Vein Invasion for Pancreatic Cancer Patients With Pancreatectomy: A Retrospective Study
RYO SAITO, HIDETAKE AMEMIYA, WATARU IZUMO, YUUKI NAKATA, SUGURU MARUYAMA, KOICHI TAKIGUCHI, KATSUTOSHI SHODA, KENSUKE SHIRAISHI, SHINJI FURUYA, YOSHIHIKO KAWAGUCHI, HIROMICHI KAWAIDA and DAISUKE ICHIKAWA

Anticancer Research February 2025, 45 (2) 773-779; DOI: https://doi.org/10.21873/anticanres.17465
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Negative Impact of High FOXP3 Status in Lymph Nodes of Esophageal Squamous Cell Carcinoma Patients
YUKIKO NONAKA, TAISUKE BABA, SHIZUKI SUGITA, KAZUSHI MIYATA, MASAKI SUNAGAWA, JUNPEI YAMAGUCHI, TOSHIO KOKURYO, YUKIHIRO YOKOYAMA and TOMOKI EBATA

Anticancer Research February 2025, 45 (2) 781-787; DOI: https://doi.org/10.21873/anticanres.17466
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Clinical Utility of Sentinel Lymph Node Biopsy Using the Medical Imaging Projection System in Breast Cancer Patients, Including Those Following Neoadjuvant Chemotherapy
AOI OSHIRO, MASAYUKI NAGAHASHI, YUSA TOGASHI, HARUKA KANAOKA, AKIRA HATTORI, JUNKO TSUCHIDA, TOMOKO HIGUCHI, ARISA NISHIMUKAI and YASUO MIYOSHI

Anticancer Research February 2025, 45 (2) 789-796; DOI: https://doi.org/10.21873/anticanres.17467
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Safety and Survival Benefit of Adjuvant Chemotherapy for Elderly Patients With Stage II/III Colon Cancer
IN JUN YANG, DONG HA KIM, KYUNG-HA LEE and JI YEON KIM

Anticancer Research February 2025, 45 (2) 797-809; DOI: https://doi.org/10.21873/anticanres.17468
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Up-regulated DDX39 in Adrenocortical Carcinoma Is Associated With Patient Survival
YOSHIATSU TANAKA, SHIN-NOSUKE YAMASHITA, SHAJEDUL ISLAM, TAKAO KITAGAWA, KAZUHIRO TOKUDA, DURGA PAUDEL, SARITA GIRI, TOHRU OHTA, FUMIYA HARADA, HIROKI NAGAYASU and YASUHIRO KURAMITSU

Anticancer Research February 2025, 45 (2) 811-815; DOI: https://doi.org/10.21873/anticanres.17469
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Impact of Perioperative Rehabilitation on Postoperative Length of Hospital Stay for Patients With Gastric Cancer
KEISUKE KOMORI, FUMIYO ABIKO, TAKU ICHIKAWA, KANAKO ANDO, RIKA SHIGEEDA, TOMOHIRO YAMAGUCHI, KEIICHI KURUSU, MASAYUKI ARAI, KAORI MISAWA, SHUJI ANDO, KAZUKI KOYAMA, KOICHIRO SHIMIZU, YUTA NAKAYAMA, YO MIKAYAMA, YOSHIHIRO SUZUKI, YASUSHI RINO and AYA SAITO

Anticancer Research February 2025, 45 (2) 817-822; DOI: https://doi.org/10.21873/anticanres.17470

Corrigenda

Open Access
Corrigenda
Anticancer Research February 2025, 45 (2) 823; DOI: https://doi.org/10.21873/anticanres.17471

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