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Research ArticleClinical Studies

Efficacy and Safety of Oral 5-FU Derivatives After Progression of HR+/HER2− Metastatic Breast Cancer on CDK4/6 Inhibitor

YUMIKO KOI, WAKAKO TAJIRI, JUNJI KAWASAKI, SAYURI AKIYOSHI, HIDEKI IJICHI, YOSHIAKI NAKAMURA, CHINAMI KOGA and ERIKO TOKUNAGA
Anticancer Research December 2025, 45 (12) 5609-5618; DOI: https://doi.org/10.21873/anticanres.17895
YUMIKO KOI
Department of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, Japan
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WAKAKO TAJIRI
Department of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, Japan
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JUNJI KAWASAKI
Department of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, Japan
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SAYURI AKIYOSHI
Department of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, Japan
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HIDEKI IJICHI
Department of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, Japan
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YOSHIAKI NAKAMURA
Department of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, Japan
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CHINAMI KOGA
Department of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, Japan
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ERIKO TOKUNAGA
Department of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, Japan
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  • For correspondence: tokunaga.eriko.pw{at}mail.hosp.go.jp
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Article Information

vol. 45 no. 12 5609-5618
DOI 
https://doi.org/10.21873/anticanres.17895
PMID 
41318158

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received September 4, 2025
  • Revision received September 21, 2025
  • Accepted September 24, 2025
  • Published online November 29, 2025.

Copyright & Usage 
Copyright © 2025 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. YUMIKO KOI,
  2. WAKAKO TAJIRI,
  3. JUNJI KAWASAKI,
  4. SAYURI AKIYOSHI,
  5. HIDEKI IJICHI,
  6. YOSHIAKI NAKAMURA,
  7. CHINAMI KOGA and
  8. ERIKO TOKUNAGA⇑
  1. Department of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, Japan
  1. Eriko Tokunaga, MD, Ph.D., Department of Breast Oncology, NHO Kyushu Cancer Center, Fukuoka, 811-1395, Japan. Tel: +81 925413231, e-mail: tokunaga.eriko.pw{at}mail.hosp.go.jp
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Anticancer Research: 45 (12)
Anticancer Research
Vol. 45, Issue 12
December 2025
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Efficacy and Safety of Oral 5-FU Derivatives After Progression of HR+/HER2− Metastatic Breast Cancer on CDK4/6 Inhibitor
YUMIKO KOI, WAKAKO TAJIRI, JUNJI KAWASAKI, SAYURI AKIYOSHI, HIDEKI IJICHI, YOSHIAKI NAKAMURA, CHINAMI KOGA, ERIKO TOKUNAGA
Anticancer Research Dec 2025, 45 (12) 5609-5618; DOI: 10.21873/anticanres.17895

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Efficacy and Safety of Oral 5-FU Derivatives After Progression of HR+/HER2− Metastatic Breast Cancer on CDK4/6 Inhibitor
YUMIKO KOI, WAKAKO TAJIRI, JUNJI KAWASAKI, SAYURI AKIYOSHI, HIDEKI IJICHI, YOSHIAKI NAKAMURA, CHINAMI KOGA, ERIKO TOKUNAGA
Anticancer Research Dec 2025, 45 (12) 5609-5618; DOI: 10.21873/anticanres.17895
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Keywords

  • Oral 5-FU derivatives
  • CDK4/6 inhibitors
  • HR-positive HER2-negative breast cancer
  • Metastatic breast cancer
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