Simultaneous Targeting of Multiple Hallmarks of Cancer With Recombinant Methioninase, Rapamycin and Chloroquine Is Specific and Synergistic to MiaPaCa-2 Pancreatic-Cancer Cells in Contrast to Hs-27 Normal Fibroblasts

JINSOO KIM; QINGHONG HAN; SHUKUAN LI; BYUNG MO KANG; KOHEI MIZUTA; YOHEI ASANO; YUTA MIYASHI; MICHAEL BOUVET; ROBERT M. HOFFMAN

doi:10.21873/anticanres.17825

Article Information

vol. 45 no. 11 4765-4770

DOI

https://doi.org/10.21873/anticanres.17825

PMID

41151914

Published By

International Institute of Anticancer Research

Print ISSN

0250-7005

Online ISSN

1791-7530

History

Received July 24, 2025
Revision received August 19, 2025
Accepted September 5, 2025
Published online October 28, 2025.

Copyright © 2025 The Author(s). Published by the International Institute of Anticancer Research. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Author Information

JINSOO KIM¹,²,³,
QINGHONG HAN¹,
SHUKUAN LI¹,
BYUNG MO KANG¹,²,
KOHEI MIZUTA¹,²,
YOHEI ASANO¹,²,
YUTA MIYASHI¹,²,
MICHAEL BOUVET² and
ROBERT M. HOFFMAN¹,² ⇑

¹AntiCancer Inc., San Diego, CA, U.S.A.;
²Department of Surgery, University of California, San Diego, CA, U.S.A.;
³Department of Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea

Robert M. Hoffman, Ph.D., AntiCancer, Inc., 7917 Ostrow Street, Suite B, San Diego, CA, 92111, U.S.A. Tel: +1 6198852284, e-mail: all{at}anticancer.com

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