Bioresorbable Membrane Composed of Sodium Hyaluronate and Carboxymethylcellulose (Seprafilm) Prevents Cancer Implantation at Peritoneal Defects in 3D-Peritoneum and Murine Models

YUTA UNE; SATORU KIKUCHI; TOMOHIRO OKURA; HIROSHI TAZAWA; EMA MITSUI; SHINJI KURODA; KAZUHIRO NOMA; SHUNSUKE KAGAWA; HOTAKA KAWAI; TOSHIAKI OHARA; JUNKO OHTSUKA; RIEKO OHKI; TOSHIYOSHI FUJIWARA

doi:10.21873/anticanres.17777

Research ArticleExperimental Studies

Bioresorbable Membrane Composed of Sodium Hyaluronate and Carboxymethylcellulose (Seprafilm) Prevents Cancer Implantation at Peritoneal Defects in 3D-Peritoneum and Murine Models

YUTA UNE, SATORU KIKUCHI, TOMOHIRO OKURA, HIROSHI TAZAWA, EMA MITSUI, SHINJI KURODA, KAZUHIRO NOMA, SHUNSUKE KAGAWA, HOTAKA KAWAI, TOSHIAKI OHARA, JUNKO OHTSUKA, RIEKO OHKI and TOSHIYOSHI FUJIWARA

Anticancer Research October 2025, 45 (10) 4261-4270; DOI: https://doi.org/10.21873/anticanres.17777

YUTA UNE

1Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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SATORU KIKUCHI

1Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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For correspondence: satorukc{at}okayama-u.ac.jp

TOMOHIRO OKURA

1Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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HIROSHI TAZAWA

1Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

2Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan;

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EMA MITSUI

1Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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SHINJI KURODA

1Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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KAZUHIRO NOMA

1Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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SHUNSUKE KAGAWA

1Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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HOTAKA KAWAI

3Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Density, and Pharmaceutical Science, Okayama, Japan;

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TOSHIAKI OHARA

1Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

4Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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JUNKO OHTSUKA

5Laboratory of Fundamental Oncology, National Cancer Center Research Institute, Tokyo, Japan

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RIEKO OHKI

5Laboratory of Fundamental Oncology, National Cancer Center Research Institute, Tokyo, Japan

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TOSHIYOSHI FUJIWARA

1Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;

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Bioresorbable Membrane Composed of Sodium Hyaluronate and Carboxymethylcellulose (Seprafilm) Prevents Cancer Implantation at Peritoneal Defects in 3D-Peritoneum and Murine Models

YUTA UNE, SATORU KIKUCHI, TOMOHIRO OKURA, HIROSHI TAZAWA, EMA MITSUI, SHINJI KURODA, KAZUHIRO NOMA, SHUNSUKE KAGAWA, HOTAKA KAWAI, TOSHIAKI OHARA, JUNKO OHTSUKA, RIEKO OHKI, TOSHIYOSHI FUJIWARA

Anticancer Research Oct 2025, 45 (10) 4261-4270; DOI: 10.21873/anticanres.17777

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Bioresorbable Membrane Composed of Sodium Hyaluronate and Carboxymethylcellulose (Seprafilm) Prevents Cancer Implantation at Peritoneal Defects in 3D-Peritoneum and Murine Models

YUTA UNE, SATORU KIKUCHI, TOMOHIRO OKURA, HIROSHI TAZAWA, EMA MITSUI, SHINJI KURODA, KAZUHIRO NOMA, SHUNSUKE KAGAWA, HOTAKA KAWAI, TOSHIAKI OHARA, JUNKO OHTSUKA, RIEKO OHKI, TOSHIYOSHI FUJIWARA

Anticancer Research Oct 2025, 45 (10) 4261-4270; DOI: 10.21873/anticanres.17777

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Keywords

peritoneal metastasis
Gastric cancer
implantation
Seprafilm
3D peritoneum model

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