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Research ArticleClinical Studies
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Tertiary Lymphoid Structures in Brain Metastases of Lung Cancer: Prognostic Significance and Correlation With Clinical Outcomes

SHOTA NOHIRA, SHUNICHIRO KURAMITSU, MASASUKE OHNO, MITSUGU FUJITA, KIMIHIRO YAMASHITA, TORU NAGASAKA, SHOICHI HAIMOTO, NORIAKI SAKAKURA, HIROKAZU MATSUSHITA and RYUTA SAITO
Anticancer Research August 2024, 44 (8) 3615-3621; DOI: https://doi.org/10.21873/anticanres.17184
SHOTA NOHIRA
1Department of Neurosurgery, Nagoya University Faculty of Medicine, Nagoya, Japan;
2Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan;
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SHUNICHIRO KURAMITSU
2Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan;
3Department of Neurosurgery, Nagoya Medical Center, Nagoya, Japan;
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MASASUKE OHNO
4Department of Neurosurgery, Aichi Cancer Center, Nagoya, Japan;
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  • For correspondence: tennjikunezumi{at}gmail.com
MITSUGU FUJITA
5Center for Medical Education and Clinical Training, Kindai University Faculty of Medicine, Osaka-Sayama, Japan;
6Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan;
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  • For correspondence: mfujita47{at}gmail.com
KIMIHIRO YAMASHITA
6Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan;
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TORU NAGASAKA
6Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan;
7Association of Medical Artificial Intelligence Curation (AMAIC), Nagoya, Japan;
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SHOICHI HAIMOTO
4Department of Neurosurgery, Aichi Cancer Center, Nagoya, Japan;
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NORIAKI SAKAKURA
8Department of Thoracic Surgery, Aichi Cancer Center, Nagoya, Japan
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HIROKAZU MATSUSHITA
2Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan;
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RYUTA SAITO
1Department of Neurosurgery, Nagoya University Faculty of Medicine, Nagoya, Japan;
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Article Information

vol. 44 no. 8 3615-3621
DOI 
https://doi.org/10.21873/anticanres.17184
PMID 
39060050

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received May 21, 2024
  • Revision received June 14, 2024
  • Accepted June 17, 2024
  • Published online July 26, 2024.

Copyright & License 
Copyright © 2024 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

  1. SHOTA NOHIRA1,2,
  2. SHUNICHIRO KURAMITSU2,3,
  3. MASASUKE OHNO4⇑,
  4. MITSUGU FUJITA5,6⇑,
  5. KIMIHIRO YAMASHITA6,
  6. TORU NAGASAKA6,7,
  7. SHOICHI HAIMOTO4,
  8. NORIAKI SAKAKURA8,
  9. HIROKAZU MATSUSHITA2 and
  10. RYUTA SAITO1
  1. 1Department of Neurosurgery, Nagoya University Faculty of Medicine, Nagoya, Japan;
  2. 2Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan;
  3. 3Department of Neurosurgery, Nagoya Medical Center, Nagoya, Japan;
  4. 4Department of Neurosurgery, Aichi Cancer Center, Nagoya, Japan;
  5. 5Center for Medical Education and Clinical Training, Kindai University Faculty of Medicine, Osaka-Sayama, Japan;
  6. 6Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan;
  7. 7Association of Medical Artificial Intelligence Curation (AMAIC), Nagoya, Japan;
  8. 8Department of Thoracic Surgery, Aichi Cancer Center, Nagoya, Japan
  1. Correspondence to: Dr. Masasuke Ohno, MD, Ph.D., Department of Neurosurgery, Nagoya Medical Center, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan. Tel: +81 527626111 (Ext 6957), e-mail: tennjikunezumi{at}gmail.com;
  2. Correspondence to: Dr. Mitsugu Fujita, MD, Ph.D., Center for Medical Education and Clinical Training, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan. Tel: +81 723660221 (Ext 5456), e-mail: mfujita47{at}gmail.com
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Tertiary Lymphoid Structures in Brain Metastases of Lung Cancer: Prognostic Significance and Correlation With Clinical Outcomes
SHOTA NOHIRA, SHUNICHIRO KURAMITSU, MASASUKE OHNO, MITSUGU FUJITA, KIMIHIRO YAMASHITA, TORU NAGASAKA, SHOICHI HAIMOTO, NORIAKI SAKAKURA, HIROKAZU MATSUSHITA, RYUTA SAITO
Anticancer Research Aug 2024, 44 (8) 3615-3621; DOI: 10.21873/anticanres.17184

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Tertiary Lymphoid Structures in Brain Metastases of Lung Cancer: Prognostic Significance and Correlation With Clinical Outcomes
SHOTA NOHIRA, SHUNICHIRO KURAMITSU, MASASUKE OHNO, MITSUGU FUJITA, KIMIHIRO YAMASHITA, TORU NAGASAKA, SHOICHI HAIMOTO, NORIAKI SAKAKURA, HIROKAZU MATSUSHITA, RYUTA SAITO
Anticancer Research Aug 2024, 44 (8) 3615-3621; DOI: 10.21873/anticanres.17184
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Keywords

  • Tertiary lymphoid structures
  • brain metastases
  • Lung cancer
  • tumor immune microenvironment (TIME)
  • prognostic biomarkers
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