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Research ArticleClinical Studies
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Clinical Outcomes of Enfortumab Vedotin in Advanced Urothelial Carcinoma With Prior Avelumab Versus Pembrolizumab Therapy

AKINORI MINATO, NOBUKI FURUBAYASHI, TOSHIHISA TOMODA, HIROYUKI MASAOKA, YOOHYUN SONG, YOSHIFUMI HORI, KEIJIRO KIYOSHIMA, TAKAHITO NEGISHI, KENTARO KUROIWA, NARIHITO SEKI, IKKO TOMISAKI, MOTONOBU NAKAMURA, KENICHI HARADA and NAOHIRO FUJIMOTO
Anticancer Research August 2024, 44 (8) 3419-3426; DOI: https://doi.org/10.21873/anticanres.17162
AKINORI MINATO
1Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan;
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  • For correspondence: a-minato{at}med.uoeh-u.ac.jp
NOBUKI FURUBAYASHI
2Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan;
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TOSHIHISA TOMODA
3Department of Urology, Oita Prefectural Hospital, Oita, Japan;
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HIROYUKI MASAOKA
4Department of Urology, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan;
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YOOHYUN SONG
4Department of Urology, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan;
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YOSHIFUMI HORI
5Department of Urology, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan;
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KEIJIRO KIYOSHIMA
6Department of Urology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan;
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TAKAHITO NEGISHI
2Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan;
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KENTARO KUROIWA
5Department of Urology, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan;
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NARIHITO SEKI
4Department of Urology, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan;
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IKKO TOMISAKI
1Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan;
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MOTONOBU NAKAMURA
2Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan;
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KENICHI HARADA
1Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan;
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NAOHIRO FUJIMOTO
7Department of Urology, Kurate Hospital, Kurate, Japan
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    Figure 1.

    Kaplan–Meier curves for (A) progression-free survival and (B) overall survival after enfortumab vedotin monotherapy initiation in patients with advanced urothelial carcinoma stratified by the type of prior immune checkpoint inhibitors.

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    Figure 2.

    Kaplan–Meier curves for overall survival after enfortumab vedotin monotherapy initiation in patients with advanced urothelial carcinoma stratified by the Bellmunt risk score.

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    Figure 3.

    Kaplan–Meier curve for overall survival after first-line platinum-based chemotherapy initiation in patients treated with enfortumab vedotin as a late-line treatment stratified by the type of prior immune checkpoint inhibitors.

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    Figure 4.

    Treatment-related adverse events of enfortumab vedotin stratified by the type of prior immune checkpoint inhibitors.

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Anticancer Research: 44 (8)
Anticancer Research
Vol. 44, Issue 8
August 2024
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Clinical Outcomes of Enfortumab Vedotin in Advanced Urothelial Carcinoma With Prior Avelumab Versus Pembrolizumab Therapy
AKINORI MINATO, NOBUKI FURUBAYASHI, TOSHIHISA TOMODA, HIROYUKI MASAOKA, YOOHYUN SONG, YOSHIFUMI HORI, KEIJIRO KIYOSHIMA, TAKAHITO NEGISHI, KENTARO KUROIWA, NARIHITO SEKI, IKKO TOMISAKI, MOTONOBU NAKAMURA, KENICHI HARADA, NAOHIRO FUJIMOTO
Anticancer Research Aug 2024, 44 (8) 3419-3426; DOI: 10.21873/anticanres.17162

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Clinical Outcomes of Enfortumab Vedotin in Advanced Urothelial Carcinoma With Prior Avelumab Versus Pembrolizumab Therapy
AKINORI MINATO, NOBUKI FURUBAYASHI, TOSHIHISA TOMODA, HIROYUKI MASAOKA, YOOHYUN SONG, YOSHIFUMI HORI, KEIJIRO KIYOSHIMA, TAKAHITO NEGISHI, KENTARO KUROIWA, NARIHITO SEKI, IKKO TOMISAKI, MOTONOBU NAKAMURA, KENICHI HARADA, NAOHIRO FUJIMOTO
Anticancer Research Aug 2024, 44 (8) 3419-3426; DOI: 10.21873/anticanres.17162
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  • Real-world Outcomes of Enfortumab Vedotin in Elderly Patients With Metastatic Urothelial Carcinoma
  • Outcomes of Enfortumab Vedotin Treatment in Patients Ineligible for the EV-301 Trial
  • Survival and Safety Outcomes of Avelumab Maintenance Therapy for Advanced Urothelial Carcinoma from a Single-Center Experience
  • Cancer-induced Pain Is Associated With Poor Overall Survival of Urothelial Carcinoma Patients Treated With Enfortumab Vedotin
  • Outcomes of Avelumab Treatment in Advanced Urothelial Carcinoma According to Age, Performance Status, and Timing
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Keywords

  • Urothelial carcinoma
  • enfortumab vedotin
  • avelumab
  • pembrolizumab
  • overall survival
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