Synergistic Effects of Melatonin on Radiosensitization in Carbon-ion Radiotherapy

MENGYANG JU; KAZUMASA MINAMI; SHOHEI KATSUKI; WATARU TAKENAKA; SHOTARO TATEKAWA; KEISUKE TAMARI; MASAHIKO KOIZUMI; YUTAKA TAKAHASHI; KAZUHIKO OGAWA

doi:10.21873/anticanres.17148

Research ArticleExperimental Studies

Synergistic Effects of Melatonin on Radiosensitization in Carbon-ion Radiotherapy

MENGYANG JU, KAZUMASA MINAMI, SHOHEI KATSUKI, WATARU TAKENAKA, SHOTARO TATEKAWA, KEISUKE TAMARI, MASAHIKO KOIZUMI, YUTAKA TAKAHASHI and KAZUHIKO OGAWA

Anticancer Research August 2024, 44 (8) 3295-3306; DOI: https://doi.org/10.21873/anticanres.17148

MENGYANG JU

1Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan;

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KAZUMASA MINAMI

1Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan;

2Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Osaka, Japan

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For correspondence: k_minami@radonc.med.osaka-u.ac.jp

SHOHEI KATSUKI

2Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Osaka, Japan

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WATARU TAKENAKA

2Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Osaka, Japan

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SHOTARO TATEKAWA

1Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan;

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KEISUKE TAMARI

1Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan;

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MASAHIKO KOIZUMI

2Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Osaka, Japan

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YUTAKA TAKAHASHI

2Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Osaka, Japan

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KAZUHIKO OGAWA

1Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan;

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vol. 44 no. 8 3295-3306

DOI

https://doi.org/10.21873/anticanres.17148

PubMed

39060064

Published By

International Institute of Anticancer Research

Print ISSN

0250-7005

Online ISSN

1791-7530

History

Received April 22, 2024
Revision received May 29, 2024
Accepted June 3, 2024
Published online July 26, 2024.

Author Information

MENGYANG JU¹,
KAZUMASA MINAMI¹,² ⇑,
SHOHEI KATSUKI²,
WATARU TAKENAKA²,
SHOTARO TATEKAWA¹,
KEISUKE TAMARI¹,
MASAHIKO KOIZUMI²,
YUTAKA TAKAHASHI² and
KAZUHIKO OGAWA¹

¹Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan;
²Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine, Osaka, Japan

Correspondence to: Kazumasa Minami, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871 Japan. Tel./Fax: +81 668792579, e-mail: k_minami{at}radonc.med.osaka-u.ac.jp

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Synergistic Effects of Melatonin on Radiosensitization in Carbon-ion Radiotherapy

MENGYANG JU, KAZUMASA MINAMI, SHOHEI KATSUKI, WATARU TAKENAKA, SHOTARO TATEKAWA, KEISUKE TAMARI, MASAHIKO KOIZUMI, YUTAKA TAKAHASHI, KAZUHIKO OGAWA

Anticancer Research Aug 2024, 44 (8) 3295-3306; DOI: 10.21873/anticanres.17148

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Synergistic Effects of Melatonin on Radiosensitization in Carbon-ion Radiotherapy

MENGYANG JU, KAZUMASA MINAMI, SHOHEI KATSUKI, WATARU TAKENAKA, SHOTARO TATEKAWA, KEISUKE TAMARI, MASAHIKO KOIZUMI, YUTAKA TAKAHASHI, KAZUHIKO OGAWA

Anticancer Research Aug 2024, 44 (8) 3295-3306; DOI: 10.21873/anticanres.17148

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Keywords

Carbon-ion radiotherapy
radiosensitivity
Melatonin
Melanoma
Osteosarcoma
DNA double-strand break
G2/M checkpoint
Gene Set Enrichment Analysis

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