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Research ArticleClinical Studies

Neoadjuvant Treatment for a cT4cN+ HER2+ Breast Cancer: Case Report of a Therapeutic Success

MARCO GUNNELLINI, ANTONIO TORNINCASA, MICHELE MONTEDORO, ANDREA CAPRODOSSI, ENRICO PROSPERI, MANOLA PEVERINI, ALESSANDRA MARIOTTINI SARTI, SILVIA AIUTI and TOMMASO MORINI
Anticancer Research June 2024, 44 (6) 2755-2758; DOI: https://doi.org/10.21873/anticanres.17084
MARCO GUNNELLINI
1Medical Oncology, Usl Umbria 1, Perugia, Italy
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  • For correspondence: marco.gunnellini{at}uslumbria1.it
ANTONIO TORNINCASA
1Medical Oncology, Usl Umbria 1, Perugia, Italy
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MICHELE MONTEDORO
1Medical Oncology, Usl Umbria 1, Perugia, Italy
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ANDREA CAPRODOSSI
2Pharmaceutical Service, Usl Umbria 1, Perugia, Italy
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ENRICO PROSPERI
3Pathological Anatomy, Usl Umbria 1, Perugia, Italy
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MANOLA PEVERINI
2Pharmaceutical Service, Usl Umbria 1, Perugia, Italy
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ALESSANDRA MARIOTTINI SARTI
2Pharmaceutical Service, Usl Umbria 1, Perugia, Italy
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SILVIA AIUTI
4Diagnostic Senology Unit, Usl Umbria 1, Perugia, Italy
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TOMMASO MORINI
2Pharmaceutical Service, Usl Umbria 1, Perugia, Italy
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Abstract

Background: HER2 positive disease accounts for 15-20% of early breast cancer. Achieving a pathological complete response after neoadjuvant chemotherapy (NACT) improves prognosis and decreases risk of recurrence. Case Report: Our case report aimed to highlight an emblematic clinical success and benefit of NACT with the addition of pertuzumab to the standard trastuzumab/taxane/anthracycline combination in a patient with a 9 cm breast neoplasm and extensive lymph node involvement (>4 pathological lymph nodes). Conclusion: Achieving a complete pathological response with NACT, should be the main goal, especially in patients with triple negative and HER2 positive breast cancer.

Key Words:
  • Breast cancer
  • neoadjuvant
  • HER2+
  • Received April 1, 2024.
  • Revision received April 9, 2024.
  • Accepted April 10, 2024.
  • Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 44 (6)
Anticancer Research
Vol. 44, Issue 6
June 2024
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Neoadjuvant Treatment for a cT4cN+ HER2+ Breast Cancer: Case Report of a Therapeutic Success
MARCO GUNNELLINI, ANTONIO TORNINCASA, MICHELE MONTEDORO, ANDREA CAPRODOSSI, ENRICO PROSPERI, MANOLA PEVERINI, ALESSANDRA MARIOTTINI SARTI, SILVIA AIUTI, TOMMASO MORINI
Anticancer Research Jun 2024, 44 (6) 2755-2758; DOI: 10.21873/anticanres.17084

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Neoadjuvant Treatment for a cT4cN+ HER2+ Breast Cancer: Case Report of a Therapeutic Success
MARCO GUNNELLINI, ANTONIO TORNINCASA, MICHELE MONTEDORO, ANDREA CAPRODOSSI, ENRICO PROSPERI, MANOLA PEVERINI, ALESSANDRA MARIOTTINI SARTI, SILVIA AIUTI, TOMMASO MORINI
Anticancer Research Jun 2024, 44 (6) 2755-2758; DOI: 10.21873/anticanres.17084
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Keywords

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