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Research ArticleExperimental Studies

Associations of Matrix Metalloproteinase-8 Genotypes to Renal Cell Carcinoma in Taiwan

CHENG-HSI LIAO, WEI-CHING CHIEN, SHU-YU CHANG, YU-HSIN LIN, YUN-CHI WANG, WEN-CHIN HUANG, MEI-CHIN MONG, YA-CHEN YANG, WEN-TZU WU, JAW-CHYUN CHEN, CHAO-HSIANG CHANG, CHIA-WEN TSAI, DA-TIAN BAU and WEN-SHIN CHANG
Anticancer Research May 2024, 44 (5) 1931-1938; DOI: https://doi.org/10.21873/anticanres.16995
CHENG-HSI LIAO
1Division of Urology, Department of Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.;
2National Defense Medical Center, Taipei, Taiwan, R.O.C.;
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WEI-CHING CHIEN
3Cell Therapy Center, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan, R.O.C.;
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SHU-YU CHANG
4Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
5Department of Nephrology, Chang-Hua Hospital, Ministry of Health and Welfare, Changhua, Taiwan, R.O.C.;
6Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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YU-HSIN LIN
4Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
6Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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YUN-CHI WANG
4Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
6Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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WEN-CHIN HUANG
4Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
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MEI-CHIN MONG
7Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.;
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YA-CHEN YANG
7Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.;
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WEN-TZU WU
7Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.;
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JAW-CHYUN CHEN
8Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.;
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CHAO-HSIANG CHANG
6Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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CHIA-WEN TSAI
4Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
6Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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DA-TIAN BAU
4Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
6Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
9Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.
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  • For correspondence: artbau2@gmail.com
WEN-SHIN CHANG
4Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.;
6Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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  • For correspondence: halittlemelon@hotmail.com
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Abstract

Background/Aim: Renal cell carcinoma (RCC) presents a formidable clinical challenge due to its aggressive behavior and limited therapeutic options. Matrix metalloproteinase-8 (MMP-8) has recently emerged as a potential biomarker and therapeutic target for various cancers. However, the genetic involvement of MMP-8 in RCC has remained largely obscure. This study aimed to elucidate the role of MMP-8 genotypes in RCC susceptibility. Materials and Methods: The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was employed to scrutinize the genotypes of MMP-8 C-799T (rs11225395), Val436Ala (rs34009635), and Lys460Thr (rs35866072) among 118 RCC patients and 590 controls. Furthermore, potential associations between MMP-8 genotypes and age, sex, smoking, alcohol consumption, hypertension, diabetes, and family history status in relation to RCC risk were assessed. Results: No significant disparities in the distribution of MMP-8 rs11225395, rs34009635, and rs35866072 genotypes were observed between the RCC case and control cohorts (p>0.05). Individuals with CT and TT genotypes at MMP-8 rs11225395 exhibited 0.86- and 0.80-fold RCC risks, respectively (OR=0.57-1.31 and 0.42-1.55, p=0.5585 and 0.6228, respectively). Intriguingly, hypertensive individuals carrying the MMP-8 rs11225395 CT or TT genotype demonstrated an elevated risk for RCC compared to those with wild-type CC genotype (p=0.0440). No interactions of MMP-8 genotypes with age, sex, smoking, alcohol consumption, or diabetes status were evident (all p>0.05). No significant association was discerned for MMP-8 rs34009635 or rs35866072 genotypes. Conclusion: MMP-8 genotypes appear to have a modest influence on individual susceptibility to RCC. Hypertensive patients with the CT or TT MMP-8 rs11225395 genotype may have an elevated risk of RCC.

Key Words:
  • Genotype
  • MMP-8
  • polymorphism
  • renal cell carcinoma
  • Taiwan
  • Received March 18, 2024.
  • Revision received March 31, 2024.
  • Accepted April 1, 2024.
  • Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Associations of Matrix Metalloproteinase-8 Genotypes to Renal Cell Carcinoma in Taiwan
CHENG-HSI LIAO, WEI-CHING CHIEN, SHU-YU CHANG, YU-HSIN LIN, YUN-CHI WANG, WEN-CHIN HUANG, MEI-CHIN MONG, YA-CHEN YANG, WEN-TZU WU, JAW-CHYUN CHEN, CHAO-HSIANG CHANG, CHIA-WEN TSAI, DA-TIAN BAU, WEN-SHIN CHANG
Anticancer Research May 2024, 44 (5) 1931-1938; DOI: 10.21873/anticanres.16995

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Associations of Matrix Metalloproteinase-8 Genotypes to Renal Cell Carcinoma in Taiwan
CHENG-HSI LIAO, WEI-CHING CHIEN, SHU-YU CHANG, YU-HSIN LIN, YUN-CHI WANG, WEN-CHIN HUANG, MEI-CHIN MONG, YA-CHEN YANG, WEN-TZU WU, JAW-CHYUN CHEN, CHAO-HSIANG CHANG, CHIA-WEN TSAI, DA-TIAN BAU, WEN-SHIN CHANG
Anticancer Research May 2024, 44 (5) 1931-1938; DOI: 10.21873/anticanres.16995
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Keywords

  • genotype
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  • polymorphism
  • Renal cell carcinoma
  • Taiwan
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