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Research ArticleExperimental Studies
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Selective Synergy of Rapamycin Combined With Methioninase on Cancer Cells Compared to Normal Cells

DANIEL ARDJMAND, YUTARO KUBOTA, MOTOKAZU SATO, QINGHONG HAN, KOHEI MIZUTA, SEI MORINAGA and ROBERT M. HOFFMAN
Anticancer Research March 2024, 44 (3) 929-933; DOI: https://doi.org/10.21873/anticanres.16887
DANIEL ARDJMAND
1AntiCancer Inc., San Diego, CA, U.S.A.;
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YUTARO KUBOTA
1AntiCancer Inc., San Diego, CA, U.S.A.;
2Department of Surgery, University of California San Diego, San Diego, CA, U.S.A.
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MOTOKAZU SATO
1AntiCancer Inc., San Diego, CA, U.S.A.;
2Department of Surgery, University of California San Diego, San Diego, CA, U.S.A.
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QINGHONG HAN
1AntiCancer Inc., San Diego, CA, U.S.A.;
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KOHEI MIZUTA
1AntiCancer Inc., San Diego, CA, U.S.A.;
2Department of Surgery, University of California San Diego, San Diego, CA, U.S.A.
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SEI MORINAGA
1AntiCancer Inc., San Diego, CA, U.S.A.;
2Department of Surgery, University of California San Diego, San Diego, CA, U.S.A.
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ROBERT M. HOFFMAN
1AntiCancer Inc., San Diego, CA, U.S.A.;
2Department of Surgery, University of California San Diego, San Diego, CA, U.S.A.
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  • For correspondence: all{at}anticancer.com
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Article Information

vol. 44 no. 3 929-933
DOI 
https://doi.org/10.21873/anticanres.16887
PMID 
38423628

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received November 21, 2023
  • Revision received December 21, 2023
  • Accepted January 10, 2024
  • Published online February 29, 2024.

Copyright & License 
Copyright © 2024 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

  1. DANIEL ARDJMAND1,
  2. YUTARO KUBOTA1,2,
  3. MOTOKAZU SATO1,2,
  4. QINGHONG HAN1,
  5. KOHEI MIZUTA1,2,
  6. SEI MORINAGA1,2 and
  7. ROBERT M. HOFFMAN1,2⇑
  1. 1AntiCancer Inc., San Diego, CA, U.S.A.;
  2. 2Department of Surgery, University of California San Diego, San Diego, CA, U.S.A.
  1. Correspondence to: Robert M. Hoffman, Ph.D., AntiCancer Inc, 7917 Ostrow St, San Diego, CA, 92111, U.S.A. Tel: +1 6198852284, e-mail: all{at}anticancer.com
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Anticancer Research: 44 (3)
Anticancer Research
Vol. 44, Issue 3
March 2024
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Selective Synergy of Rapamycin Combined With Methioninase on Cancer Cells Compared to Normal Cells
DANIEL ARDJMAND, YUTARO KUBOTA, MOTOKAZU SATO, QINGHONG HAN, KOHEI MIZUTA, SEI MORINAGA, ROBERT M. HOFFMAN
Anticancer Research Mar 2024, 44 (3) 929-933; DOI: 10.21873/anticanres.16887

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Selective Synergy of Rapamycin Combined With Methioninase on Cancer Cells Compared to Normal Cells
DANIEL ARDJMAND, YUTARO KUBOTA, MOTOKAZU SATO, QINGHONG HAN, KOHEI MIZUTA, SEI MORINAGA, ROBERT M. HOFFMAN
Anticancer Research Mar 2024, 44 (3) 929-933; DOI: 10.21873/anticanres.16887
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  • Lack of Cancer Specificity of Methionine Adenosyltransferase 2A (MAT2A) Inhibitor AG-270 in Combination With Recombinant Methioninase In Vitro
  • Simultaneous Targeting of Multiple Hallmarks of Cancer With Recombinant Methioninase, Rapamycin and Chloroquine Is Specific and Synergistic to MiaPaCa-2 Pancreatic-Cancer Cells in Contrast to Hs-27 Normal Fibroblasts
  • Very Rapid Eradication of a Large Squamous-Cell Carcinoma of the Head and Neck Treated With First-line Combination Chemotherapy, a Low-methionine Diet, and Oral Recombinant Methioninase
  • The Triple Combination of Recombinant Methioninase, Rapamycin, and Chloroquine Synergistically Eradicates HCT116 Colon Cancer Cells
  • Human fibrosarcoma cells selected for very-high doxorubicin resistance, acquire trabectedin and eribulin cross-resistance, remain sensitive to recombinant methioninase, and have increased c-MYC expression
  • Combination of Recombinant Methioninase With Rapamycin or Chloroquine Is Synergistic to Highly Inhibit Triple-negative Breast Cancer Cells In Vitro
  • Highly Synergistic Eradication of 143B Osteosarcoma Cells In Vitro by the Combination of Recombinant Methioninase, Chloroquine, and Rapamycin Targeting Methionine Addiction, Autophagy, and mTOR, Respectively
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Keywords

  • methioninase
  • rMETase
  • rapamycin
  • mTOR
  • SAMTOR
  • SAM
  • combination
  • synergy
  • cancer cells
  • normal cells
  • IC50
  • HCT-116
  • Hs-27
  • Methionine addiction
  • Hoffman effect
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