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Research ArticleExperimental Studies

Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells

DÓRA HEGEDŰS, NIKOLETTA SZEMERÉDI, MAJA GÁBOR, JUDIT SAS, KHADIJA BELASRI, ISTVÁN SZATMÁRI and GABRIELLA SPENGLER
Anticancer Research March 2024, 44 (3) 1149-1160; DOI: https://doi.org/10.21873/anticanres.16910
DÓRA HEGEDŰS
1Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary;
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NIKOLETTA SZEMERÉDI
2Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary;
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MAJA GÁBOR
2Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary;
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JUDIT SAS
1Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary;
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KHADIJA BELASRI
1Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary;
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ISTVÁN SZATMÁRI
1Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary;
3HUN-REN–SZTE Stereochemistry Research Group, University of Szeged, Szeged, Hungary
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  • For correspondence: szatmari.istvan{at}szte.hu
GABRIELLA SPENGLER
2Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary;
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  • For correspondence: spengler.gabriella{at}med.u-szeged.hu
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Article Information

vol. 44 no. 3 1149-1160
DOI 
https://doi.org/10.21873/anticanres.16910
PMID 
38423632

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received December 20, 2023
  • Revision received January 23, 2024
  • Accepted January 29, 2024
  • Published online February 29, 2024.

Copyright & Usage 
Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. DÓRA HEGEDŰS1,
  2. NIKOLETTA SZEMERÉDI2,
  3. MAJA GÁBOR2,
  4. JUDIT SAS1,
  5. KHADIJA BELASRI1,
  6. ISTVÁN SZATMÁRI1,3⇑ and
  7. GABRIELLA SPENGLER2⇑
  1. 1Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary;
  2. 2Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary;
  3. 3HUN-REN–SZTE Stereochemistry Research Group, University of Szeged, Szeged, Hungary
  1. Correspondence to: Gabriella Spengler, Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Semmelweis utca 6, 6725 Szeged, Hungary. Tel: +36 62545115, e-mail: spengler.gabriella{at}med.u-szeged.hu;
  2. Correspondence to: István Szatmári, Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary. Tel: +36 62545563, e-mail: szatmari.istvan{at}szte.hu
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Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells
DÓRA HEGEDŰS, NIKOLETTA SZEMERÉDI, MAJA GÁBOR, JUDIT SAS, KHADIJA BELASRI, ISTVÁN SZATMÁRI, GABRIELLA SPENGLER
Anticancer Research Mar 2024, 44 (3) 1149-1160; DOI: 10.21873/anticanres.16910

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Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells
DÓRA HEGEDŰS, NIKOLETTA SZEMERÉDI, MAJA GÁBOR, JUDIT SAS, KHADIJA BELASRI, ISTVÁN SZATMÁRI, GABRIELLA SPENGLER
Anticancer Research Mar 2024, 44 (3) 1149-1160; DOI: 10.21873/anticanres.16910
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Keywords

  • aza-Friedel–Crafts reaction
  • indole skeleton
  • modified Mannich reaction
  • efflux pump inhibitor (EPI)
  • anti-biofilm
  • P-glycoprotein (ABCB1) inhibition
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