Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells

DÓRA HEGEDŰS; NIKOLETTA SZEMERÉDI; MAJA GÁBOR; JUDIT SAS; KHADIJA BELASRI; ISTVÁN SZATMÁRI; GABRIELLA SPENGLER

doi:10.21873/anticanres.16910

Research ArticleExperimental Studies

Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells

DÓRA HEGEDŰS, NIKOLETTA SZEMERÉDI, MAJA GÁBOR, JUDIT SAS, KHADIJA BELASRI, ISTVÁN SZATMÁRI and GABRIELLA SPENGLER

Anticancer Research March 2024, 44 (3) 1149-1160; DOI: https://doi.org/10.21873/anticanres.16910

DÓRA HEGEDŰS

1Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary;

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NIKOLETTA SZEMERÉDI

2Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary;

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MAJA GÁBOR

2Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary;

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JUDIT SAS

1Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary;

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KHADIJA BELASRI

1Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary;

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ISTVÁN SZATMÁRI

1Institute of Pharmaceutical Chemistry, University of Szeged, Szeged, Hungary;

3HUN-REN–SZTE Stereochemistry Research Group, University of Szeged, Szeged, Hungary

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For correspondence: szatmari.istvan{at}szte.hu

GABRIELLA SPENGLER

2Department of Medical Microbiology, Albert Szent-Györgyi Health Center and Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary;

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For correspondence: spengler.gabriella{at}med.u-szeged.hu

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Anticancer Research

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March 2024

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Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells

DÓRA HEGEDŰS, NIKOLETTA SZEMERÉDI, MAJA GÁBOR, JUDIT SAS, KHADIJA BELASRI, ISTVÁN SZATMÁRI, GABRIELLA SPENGLER

Anticancer Research Mar 2024, 44 (3) 1149-1160; DOI: 10.21873/anticanres.16910

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Cyclic Amines Coupled to Indole Derivatives With Improved Efflux Pump Inhibiting Activity in Bacteria and Cancer Cells

DÓRA HEGEDŰS, NIKOLETTA SZEMERÉDI, MAJA GÁBOR, JUDIT SAS, KHADIJA BELASRI, ISTVÁN SZATMÁRI, GABRIELLA SPENGLER

Anticancer Research Mar 2024, 44 (3) 1149-1160; DOI: 10.21873/anticanres.16910

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Keywords

aza-Friedel–Crafts reaction
indole skeleton
modified Mannich reaction
efflux pump inhibitor (EPI)
anti-biofilm
P-glycoprotein (ABCB1) inhibition

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