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Research ArticleExperimental Studies

5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrin Zinc and Chloro-aluminum Phthalocyanine Disulfonate in Photodynamic Therapy of Colorectal Adenocarcinoma In Vitro

JAKUB HOSIK, BARBORA HOSIKOVA, HANA KOLAROVA and ROBERT BAJGAR
Anticancer Research October 2024, 44 (10) 4339-4346; DOI: https://doi.org/10.21873/anticanres.17263
JAKUB HOSIK
Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Olomouc, Czech Republic
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BARBORA HOSIKOVA
Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Olomouc, Czech Republic
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HANA KOLAROVA
Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Olomouc, Czech Republic
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ROBERT BAJGAR
Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University in Olomouc, Olomouc, Czech Republic
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  • For correspondence: robert.bajgar@upol.cz
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Abstract

Background/Aim: Colorectal cancer (CRC) is one of the most widespread malignancies. One of the alternative therapeutic methods appears to be photodynamic therapy (PDT). Materials and Methods: This study investigated the efficiency of 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin zinc (ZnTPPS4) and chloro-aluminum phthalocyanine disulfonate (ClAlPcS2) with two commercial photosensitive compounds 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP) and tetramethylthionine chloride (methylene blue, MB) in PDT for CRC in vitro. In addition to the study of the photodynamic effect on the viability of the colorectal carcinoma cell line HT29, cellular uptake, ROS production, and DNA damage were investigated. Results: All photosensitizers showed good accumulation within HT29 cells, high efficiency in killing the cells, and a concentration-dependent increase in the production of ROS. Conclusion: PDT using ZnTPPS4 and ClAlPcS2 may be effective in the treatment of CRC, achieving a similar photocytotoxic effect at much lower concentrations compared to MB.

Key Words:
  • Colorectal adenocarcinoma
  • DNA fragmentation
  • photodynamic therapy
  • phthalocyanines
  • porphyrins
  • reactive oxygen species
  • Received August 12, 2024.
  • Revision received September 2, 2024.
  • Accepted September 3, 2024.
  • Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 44 (10)
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October 2024
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5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrin Zinc and Chloro-aluminum Phthalocyanine Disulfonate in Photodynamic Therapy of Colorectal Adenocarcinoma In Vitro
JAKUB HOSIK, BARBORA HOSIKOVA, HANA KOLAROVA, ROBERT BAJGAR
Anticancer Research Oct 2024, 44 (10) 4339-4346; DOI: 10.21873/anticanres.17263

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5,10,15,20-Tetrakis(4-sulfonatophenyl)porphyrin Zinc and Chloro-aluminum Phthalocyanine Disulfonate in Photodynamic Therapy of Colorectal Adenocarcinoma In Vitro
JAKUB HOSIK, BARBORA HOSIKOVA, HANA KOLAROVA, ROBERT BAJGAR
Anticancer Research Oct 2024, 44 (10) 4339-4346; DOI: 10.21873/anticanres.17263
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Keywords

  • Colorectal adenocarcinoma
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  • phthalocyanines
  • porphyrins
  • reactive oxygen species
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