Book Reviews

Editorial Policy. Recently published books and journals (one copy) are invited by the Editorial Office for announcement and review in ANTICANCER RESEARCH (no fee). Each announcement should include the full title of the publication, authors or editors, the number of pages, price, year of publication, ISBN and publisher. Publishers will be notified upon receipt of books and tear sheets of reviews will be sent after publication. Books will be returned to the sender only if the announcement is rejected. Reviews will be objective and clear regarding the content, quality and usefulness of the publication.

Human Histology. A Text and Atlas for Physicians and Scientists.

Edited by B. Dudas.

2023, pp 386, USD 170.00, ISBN: 978-0-323-91891-6.

Academic Press, Elsevier, Cambridge, MA, USA.

Visually engaging and easy to use, Human Histology: A Text and Atlas for Physicians and Scientists covers the normal histology of every organ in the human body. This book presents full-page high-definition photomicrographs for organs and tissues, followed by a compact and simple-to-read description of the structures identified on the micrographs, offering a clear, visual understanding of this complex subject. With over 300 outstanding images, this reference is an invaluable resource for every clinical researcher and pathologist in need of easily accessible, relatively simple but detailed enough information on normal histology of different organs systems. Due to its compact, but detailed layout, the volume is an excellent tool for medical board review and can be recommended for medical students and histology course directors.

Key Features: Contains full-color photomicrographs that clarify microanatomy in detail; Provides easy-to-find comprehensive information on normal histology of different organs systems; Features high-resolution full-page micrographs of organs and tissues surrounded by inserts of magnified parts of the sample.

Comparative Mammalian Immunology. The Evolution and Diversity of the Immune Systems of Mammals. 1st Edition.

Edited by I.R. Tizard.

2023, pp 458, USD 127.50, ISBN: 978-0-323-95219-4.

Academic Press, Elsevier, Cambridge, MA, USA.

Comparative Mammalian Immunology: The Evolution and Diversity of the Immune Systems of Mammals provides a review on the current knowledge of mammalian immune systems from a comparative viewpoint. This reference encompasses recent work on the immune systems of marine mammals, bats and marsupials in addition to other lesser-known species, with the immune systems of humans and laboratory mice as components of chapters on primates and rodents respectively. The book also makes use of the most recent studies on the genomic sequences of the mammals to identify both common and unique features of each mammal’s immune system.

The book elucidates the complex, but coordinated and controlled series of interactions involving cells and molecules that has evolved to protect the host against disease. Mammals consist of a highly diverse group of animals in which the immune system has been subjected to a variety of selective pressures. This is reflected in differences in the organization and function of their immune systems, and is especially seen in those gene families characterized by complexity and polymorphism..

Key Features: Demonstrates multiple diverse pathways and mechanisms to optimize resistance and survival in the face of infectious diseases; Shows the clear patterns of emergence of different immunologic traits among the diverse orders of mammals; Reflects issues with innate or adaptive immune systems; Serves as a comprehensive review of the current state of knowledge of the immune system of each mammalian order.

Effect of High-Pressure Technologies on Enzymes. Science and Applications. 1st Edition.

Edited by B.R. Leite Junior, A.A. Tribst.

2023, pp 464, USD 148.75, ISBN: 978-0-323-98386-0.

Academic Press, Elsevier, Cambridge, MA, USA.

Effect of High-Pressure Technologies on Enzyme: Science and Applications provides a deep, practical discussion of high-pressure processing (HPP) and high-pressure homogenization (HPH) technologies and biochemical approaches, applied across research and industry, with applications ranging from food to pharmaceuticals and commercial enzyme production. Early chapters discuss foundational aspects of HPP and HPH approaches; the science of enzyme modification; and basic aspects of enzyme activity, stability, and structure as studied in biochemical processes. Later chapters consider the effect of HPP and HPH technologies and their mechanisms of controlling enzyme modification to improve enzyme performance for chosen applications. Special attention is paid to the application of HPP and HPH technologies and enzyme modifications in food processing, microbial enzyme modification, drug discovery, and production of other commercial enzymes, as well as the challenges of undesirable enzyme inactivation. The final chapter discusses future directions of the field and technologies, and expanded applications..

Key Features: Offers a broad overview of HPP and HPH approaches and technologies applied in enzyme modification; Introduces fundamental aspects of enzyme activity, stability, and structure as studied in biochemical processes and applications; Discusses applications of HPP- and HPH-based enzyme modifications in food processing, microbial enzyme modification, drug discovery, and production of other commercial enzymes; Includes chapter contributions from international leaders in the field, across research and industry.

Transcription and Translation in Health and Disease. 1st Edition.

Edited by M. Garg, G. Sethi, A.K. Pandey.

2023, pp 416, USD 140.25, ISBN: 978-0-323-99521-4.

Academic Press, Elsevier, Cambridge, MA, USA.

Transcription and Translation in Health and Disease provides a detailed overview of the regulators underlying transcription and translation in relation to a variety of human diseases and disorders. Beginning with an introduction into the current perspectives relating to these processes in human disease, the book expands to focus on specific mechanisms underlying conditions such as arthritis, cancer, neurological disorders, diabetes and cardiovascular disease. This book considers RNA processing and related mechanisms in eukaryotes including RNA splicing, RNA binding proteins, RNA interference, microRNAs, RNA editing, transcription factors, RNAi screening, CRISPR activation, CRISPR-Cas9 interference, and post-translational modifications.

It provides a structured and detailed overview of the various regulators underlying molecular processes and their impact on health and disease, equipping readers with the necessary knowledge for further investigation in the areas of treatment and therapeutic intervention..

Key Features: Discusses the role played by transcription and translational regulation in various diseases, including cancer, diabetes, cardiovascular disease and neurological disease; Considers a range of post-transcriptional regulators, including RNA-binding proteins, non-coding RNAs, epigenetic modifiers, alternative splicing and telomerase-binding proteins; Covers the topic from fundamental knowledge to the latest developments in clinical application; Includes a section dedicated to therapeutic applications.

Translational Autoimmunity, Volume 6. Advances in Autoimmune Rheumatic Diseases. 1st Edition.

Edited by N. Rezaei.

2023, pp 628, USD 148.75, ISBN: 978-0-323-85831-1.

Academic Press, Elsevier, Cambridge, MA, USA.

Translational Autoimmunity: Advances in Autoimmune Rheumatic Diseases, Volume Six addresses autoimmune diseases classified under the category of rheumatic diseases. Rheumatic diseases are heterogeneous groups of disorders in which inflammation affects not only joints, but also tendons, ligaments and bones. This updated release focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases, including rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, osteoarthritis and Sjogren’s syndrome, and will be of interest to researchers, students and clinicians interested in autoimmune diseases, especially rheumatic diseases.

From an introduction to rheumatic diseases to diagnostic laboratory tests, and from the microbiota-immunity to cell-based therapies, the bench to bedside approach to rheumatic diseases is the main subject of discussion in this comprehensive resource..

Key Features: Gives an introduction on rheumatic diseases, from bench to bedside; Describes diagnostic laboratory tests in rheumatic diseases; Meets the needs of basic scientists, clinicians and translational scientists and industry partners; Focuses on immunopathogenesis and clinical and laboratory details of rheumatic diseases.

Principles of Genomics and Proteomics. 1st Edition.

Edited by R.A. Mir, S. Shafi, S.M. Zargar.

2023, pp 274, USD 106.25, ISBN: 978-0-323-99045-5.

Academic Press, Elsevier, Cambridge, MA, USA.

Principles of Genomics and Proteomics is the perfect reference for graduate students and researchers in these areas to understand its principles and execute precise and reproducible experiments. Following an introductory chapter, the book dives into proper research, including genome mapping. Experiments covered in the book span from Sangers Sequencing, Shotgun sequencing, SAGE analysis, DNA footprinting, Gel retardation, ChIP, and protein resolution methods, including PAGE, 2D gel electrophoresis and isoelectric focusing. Biophysical techniques are also described in detail, including ultraviolet and visible light spectroscopy, fluorescence spectroscopy, NMR and X-ray diffraction.

A final proteome analysis is dedicated to functional analysis. Other chapters cover applications of omics technologies broadly. This book is the perfect reference for genetics labs around the world. Graduate students will benefit from the structured and detailed coverage of methods and established researchers will benefit from the book for staff training in research and may find it particularly helpful in enhancing reproducibility of experiments..

Key Features: Provides a comprehensive accounting of the technical aspects of genomic and proteomic analysis and applications in living organisms; Includes detailed and standardized coverage of basic research methods in areas covered; Presents advanced applications of genomics and proteomics that are highlighted with major significance in medical and agricultural fields.

Cann’s Principles of Molecular Virology. 7th Edition.

Edited by E. Rybicki.

2023, pp 398, USD 84.95, ISBN: 978-0-128-22784-8.

Academic Press, Elsevier, Cambridge, MA, USA.

Cann’s Principles of Molecular Virology, Seventh Edition provides an easily accessible introduction to modern virology, presenting principles in a clear and concise manner. The new edition provides the history of virology and the fundamentals of the molecular basis of how viruses work. It discusses the interactions which control the structure of virus particles, the ways viruses infect cells, how viruses replicate themselves, and the consequences and pathogenesis of virus infection for host organisms. This fully updated edition also reflects advances made in the field and includes new content on phage therapy, CRISPR as a phage defense / offense system, new ideas about evolution, and giant viruses. With the addition of ancillary resources, Principles of Molecular Virology, Seventh Edition is an essential foundational reference for academics, graduate students, and advance undergraduates in virology, molecular biology, and microbiology as well as researchers entering virology, infectious disease, and immunology research..

Key Features: Provides a conceptual approach to the principles of molecular virology, with important examples of new advances in virology; Includes new concepts in this edition include coverage of emerging topics and new technologies in viral research like phage therapy, CRISPR as a phage defense/offense system, new ideas about evolution, and giant viruses; Contains updated learning outcomes and further reading for each chapter; Supported by online resources for students and instructors.

Essential Oils. Extraction, Characterization and Applications. 1st Edition.

Edited by G. Nayik, M.J. Ansari.

2023, pp 526, USD 170.00, ISBN: 978-0-323-91740-7.

Academic Press, Elsevier, Cambridge, MA, USA.

Essential Oils: Extraction, Characterization and Applications covers sixteen essential oils from different herbal and aromatic plants, including production, composition and extraction techniques such as distillation, chemistry and properties, characterization and applications. The book also presents their safety, toxicity and regulation, alongside trade, storage, stability and transport concepts. Essential oils in plants, extraction and analysis, and current trends in the use of essential oils, like aroma therapy, agro-food and non-food usage are thoroughly explored. Remaining chapters are dedicated to different essential oils, including lavender, peppermint, sandalwood, citrus, eucalyptus, tea tree, clove, ginger, cinnamon, nutmeg, rosewood, juniper and pine, patchouli, clary, and more.

Edited by a global team of experts in essential oils, this book is designed to be a practical tool for the many diverse professionals who develop and market essential oils.

Key Features: Thoroughly explores the extraction and characterization of essential oils; Contains comprehensive information on major, popular essential oils; Provides an exceptional range of information on properties, applications, safety, toxicity and regulations.

Comprehensive Guide to Hepatitis Advances. 1st Edition.

Edited by W.-K. Seto, M. Eslam.

2023, pp 676, USD 148.75, ISBN: 978-0-323-98368-6.

Academic Press, Elsevier, Cambridge, MA, USA.

The Comprehensive Guide to Hepatitis Advances provides the most up-to-date information on all types of hepatitis in one resource. Coverage spans hepatitis in all forms (viral, alcoholic, metabolic, drug, autoimmune, etc.), showing the implications of current research in clinical practice and discussing future research directions. Discussions focus on the scientific advancements in understanding the disease process and in the treatment of different groups of hepatitis. This reference is perfect for basic science researchers in the field of hepatology; practicing gastroenterologists and hepatologists as well as primary care physicians attending to liver disease; and medical residents undergoing specialist training in gastroenterology and hepatology.

Key Features: Provides comprehensive coverage of the different types of hepatitis; Highlights the most recent research findings related to different types of hepatitis and their impact on clinical care; Discusses future development specific to different types of hepatitis.

Introductory Immunology. Basic Concepts for Interdisciplinary Applications. 3rd Edition

Edited by J. Actor.

2023, pp 224, USD 102.00, ISBN: 978-0-443-15307-5.

Academic Press, Elsevier, Cambridge, MA, USA.

Introductory Immunology: Basic Concepts for Interdisciplinary Applications, 3rd Edition, is a completely updated, revised, and expanded concise, conceptual approach to understanding the immune systems as a primary defense to maintain health and homeostasis. This expanded version includes the aspects of microbiology and related immune defense mechanisms important in combating disease, as well critical components related to the field of vaccine development.

Immunology as a subject is no longer confined to the realms of “immunology” or “microbiology” studies. Indeed, the subject matter has become increasingly important to understand complex mechanisms found within a wider range of biological systems. This book aims specifically at educated audiences who do not have a deep understanding of medical, biochemical, or cellular knowledge. The overall text will present concepts that portray a comprehensive picture of the natural defenses to infectious agents as well as provide an introduction to mechanisms that lead to autoimmune dysfunction. In addition, immunological diseases will be detailed, with the goal of allowing the readers to gain sufficient knowledge to make sound choices for clinical decisions to affect treatment outcomes.

This new edition expands on the existing chapters, focusing on updating the previous text. It has been expanded to include knowledge on effector mechanisms addressing components inherent within cellular responses that are either newly discovered or missing from the previous edition. It has an extra emphasis on aspects related to mechanisms important in combating microbial agents and critical sections on how vaccines protect against pathogenic invaders to limit associated pathology.

The goal is that Introductory Immunology will become the preferred provider of core knowledge in immunology to build a foundation to explore components of the human immune system that work together to confer and understand dysregulation that causes clinical diseases. This book serves as a basic platform to define therapeutic interventions by: creating appreciation for components of the human immune system to work together to confer lifelong protection; providing a core knowledge in immunology to build a foundation to explore mechanisms involved in clinical disease, and defining functional aspects of immunological terms to permit the reader easy access to comprehend specific topics; presenting introduction to complex immunological concepts in a concise and easy manner that relates to clinical disease; breaking down all of immunology into manageable, logically digestible building blocks, and providing a map to explore overlapping mechanisms of immune protective responses; providing a platform to readers without medical, biochemical, or cellular expertise to understand and appreciate how immunology controls homeostasis and protects against pathogens.

Laboratory Animal Anaesthesia and Analgesia. 5th Edition.

Edited by P. Flecknell.

2023, pp 376, USD 127.50, ISBN: 978-0-128-18268-0.

Academic Press, Elsevier, Cambridge, MA, USA.

Laboratory Animal Anaesthesia and Analgesia, Fifth Edition provides a basic guide to anesthesia for a very diverse audience involved in animal testing. This has been the go-to resource for current, clear, and evidence-based information for over 30 years. The book is divided into four parts that deal with preparation for anesthesia, including definitions, equipment, preparations, anesthetic and analgesic agents, the management and monitoring of anesthesia, including pre-procedural preparations, monitoring and problems and emergencies through the procedure, advanced and specialized techniques, and analgesia and post-operative care, including recovery and the prevention and management of postoperative pain.

Final sections cover anesthesia in common laboratory species, specifically: rodents, rabbits, cats, dogs, ferrets, pigs, sheep and goats, primates, reptiles, amphibians and new specific chapters on birds, fish and cephalopods. This edition keeps up with the tradition of bringing a balanced dose of practical advice, foundational content, and current, updated references, drugs and procedures to veterinarians, technicians, researchers and ethics committee personnel.

Key Features: Includes an updated list of agents and current anesthetic procedures; Expanded to cover fish, birds, and cephalopods; Provides a new and comprehensive formulary table covering anesthetics and analgesics for all species presented.

Targeted Protein Degradation. 1st Edition.

Edited by G. Burslem.

2023, pp 340, USD 169.15, ISBN: 978-0-323-99200-8.

Academic Press, Elsevier, Cambridge, MA, USA.

Targeted Protein Degradation, Volume 681 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of timely topics, with each written by an international board of authors.

Key Features: Provides the authority and expertise of leading contributors from an international board of authors; Presents the latest release in Methods in Enzymology serials; Updated release includes the latest information on Targeted Protein Degradation.

Environmental Carcinogenesis. 1st Edition.

Edited by M. Costa.

2023, pp 380, USD 192.00, ISBN: 978-0-323-99775-1.

Academic Press, Elsevier, Cambridge, MA, USA.

Environmental Carcinogenesis, Volume 96 in the Advances in Pharmacology series, reports on work done with carcinogenic metals and the mechanisms of their carcinogenicity, including Arsenic and Chromate. Chapters in this release include Breast cancer carcinogenesis by organophosphate pesticides, Polyadenylation of Canonical histone H3.1 in Carcinogenesis, Epigenomic reprogramming in iAs-mediated carcinogenesis, MicroRNAs and epigenetic regulation in metal-induced angiogenesis and carcinogenesis, Environmental epigenetics and new mechanistic markers of chemical exposure, Arsenic carcinogenesis by inhibition of DNA repair, Genetic and environmental reprogramming of the sarcoma epigenome, Mechanism of chromate carcinogenesis by chromatin alterations, and more.

Other chapters cover Arsenic carcinogenesis and microRNAs, Epigenetic mechanism of Cr(VI)-induced cell malignant transformation and tumorigenesis, The dark side of NRF2 in arsenic carcinogenesis, and Chemical mechanisms of DNA damage by carcinogenic chromium(VI).

Key Features: Covers metal carcinogens; Includes discussions on the mechanisms of cancer formation; Provides updates on the diverse mechanisms that drive cancer formation by metals.

Novel Methods and Pathways in Cancer Glycobiology Research. 1st Edition.

Edited by C. Dimitroff, D. Abbott.

2023, pp 304, USD 145.35, ISBN: 978-0-323-99177-3.

Academic Press, Elsevier, Cambridge, MA, USA.

Cancer glycobiology is a blazing hot area of cancer research with aberrant post-translational glycosylations on lipids and proteins considered critical for cancer development and metastasis. The NIH/NCI Alliance of Glycobiologists for Cancer Research is a consortium of 10 tumor glycobiology laboratories funded to investigate how cancer-associated glycans (CAG) impact the development and metastasis of cancer. The hope of this momentous effort is to discover CAGs for use as novel biomarkers to detect early-stage cancer or its aggressive behavior or, alternatively, as novel molecular targets with the promise of a curative approach to cancer therapy. The mission of the ‘Alliance’ is to study structure and function of CAGs in cancer development and to provide clinically useful biomarkers for detecting cancer early or the potential of metastasis. This charge has stimulated extensive collaborations across US and International institutions to accelerate discovery of glycan-based biomarkers to the forefront of NCI’s efforts to diagnose early-stage cancer and provide curative anti-cancer therapies.

The main goals of these research efforts are: 1. To identify and study how cancer-associated glycans functionally impact cancer growth and metastasis; 2. To identify cancer-associated glycans that can serve as biomarkers for the detection or progression of cancer; 3. To develop cancer-associated glycans as novel therapeutic targets for the treatment and cure of cancer.

This volume consists of 9 chapters, one from each funded laboratory, that reviews new methods and mechanisms highlighting glycoconjugates and their roles as cancer biomarkers and/or anti-cancer therapeutic targets.

Key Features: Historical and novel glycobiological biomarkers of cancer and disease progression; Novel glycobiological mechanisms driving cancer progression; Novel methods for discovering glycobiological biomarkers of cancer.

Receptor Endocytosis and Signalling in Health and Disease - Part A. 1st Edition.

Edited by I. Mani, V. Singh.

2023, pp 422, USD 145.35, ISBN: 978-0-443-19185-5.

Academic Press, Elsevier, Cambridge, MA, USA.

Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field. Chapters in this release include: An overview on receptor endocytosis and signaling, Signaling molecules: Importance in health and disease conditions, Emerging tools for studying of receptor endocytosis and signaling, Endocytosis of EGFR: Signalling in cancer, Endocytosis of AT1 and AT2 receptors: Signalling in the kidney, Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants, Endocytosis of Insulin receptor: Signalling in the regulation of glucose homeostasis, Endocytosis of VEGFR: Role in the regulation of angiogenesis, and more.

Other sections in this new release include: Lymphocyte and monocyte/macrophage receptors mediating immune recognition of tumors, Lymphocyte and monocyte/macrophage receptors triggering immune suppression of tumor immunity, Prion receptors and prion internalization and intra- and inter-cellular transport, Multifunctional role of the ubiquitin proteasome pathway in phagocytosis, Adrenoceptors and SCD1 in adipocytes/adipose tissues: the expression and variation in health and obesity, Frizzled receptors and SFRP5 in lipid metabolism: current findings and potential applications.

Key Features: Provides the authority and expertise of leading contributors from an international board of authors; Presents the latest release in the Progress in Molecular Biology and Translational Science series; Includes the latest information on Receptor Endocytosis and Signaling in Health and Disease.

Proteomics. A Promising Approach for Cancer Research. 1st Edition.

Edited by S. Ali, S. Majid, M. Rehman.

2023, pp 412, USD 140.25, ISBN: 978-0-323-95072-5.

Academic Press, Elsevier, Cambridge, MA, USA.

Proteomics: A Promising Approach for Cancer Research provides an updated overview of scientific knowledge, achievements and findings in the field of cancer proteomics. The book discusses topics such as the use of proteomics in cancer biology and drug discovery, its role in surgical oncology, applications of mass spectrometry, target proteomics, single-cell proteomics, and next-generation proteomics. In addition, it discusses proteomics and phosphor-proteomics in cancer precision medicine; translation of proteomics research into clinical application; and challenges and future developments of the field. This will be a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical field who are interested in the potential of proteomics in cancer research and treatment.

The field of cancer proteomics is very dynamic, with emerging trends related to clinical solutions developed in recent years, therefore this book’s content helps readers get up-to-speed on the topic to easily apply learnings into their research or clinical practice.

Key Features: Provides up-to-date information on current cancer proteomics research developed globally; Presents basic research aspects to clinical implications of proteomics on cancer diagnosis and potential treatments; Discusses challenges and future developments of the field to leverage further research and applicability in clinical setting.

Epigenetics in Organ Specific Disorders. 1st Edition.

Edited by C. Boosani, R. Goswami.

2022, pp 666, USD 131.25, ISBN: 978-0-128-23931-5.

Academic Press, Elsevier, Cambridge, MA, USA.

Epigenetics in Organ Specific Disorders, a new volume in the Translational Epigenetics series, provides a foundational overview and nuanced analysis of epigenetic gene regulation distinct to each organ type and organ specific disorders, fully elucidating the epigenetics pathways that promote and regulate disease. After a brief introduction, chapter authors compare epigenetic regulations across normal and disease conditions in different organ tissues, exploring similarities and contrasts. The role of epigenetic mechanisms in stem cells, cell-matrix interactions and cell proliferation, cell migration, cellular apoptosis, necrosis, pyknosis, tumor suppression, and immune responses across different organ types are examined in-depth. Organ specific epigenetic mechanisms and biomarkers of early use in developing drugs, which can selectively target the organ of interest, are also explored to enable new precision therapies.

Key Features: Identifies unique epigenetic mechanisms that occur in normal and disease conditions in each organ, examining differences and similarities; Explores organ specific epigenetic mechanisms to enable drug discovery and development; Features chapter contributions from leading researchers in the field.

Overcoming Resistance to EGFR Inhibitors in EGFR-Mutant NSCLC.

Edited by A.C. Faber.

2023, pp 150, USD 148.75, ISBN: 978-0-12-822833-3.

Academic Press, Elsevier, Cambridge, MA, USA.

Overcoming Resistance to EGFR Inhibitors in EGFR-Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, and the clinical strategies to identify these mechanisms and implement newer therapeutic strategies to combat resistance to improve patient survival.

The book covers resistance mechanisms to EGFR inhibitors in EGFR-mutant lung cancer and therapeutic strategies being explored to overcome resistance. As resistance to EGFR inhibitors is often through reactivation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as MEK pathway inhibitors in BRAF-mutant melanoma and

ALK inhibitors in ALK translocated lung cancer. This book also discusses current clinical trials involving EGFR inhibitors in EGFR-mutant lung cancer and explains the methodology of detection of resistance mechanisms in the lung cancer clinic. This book is a valuable resource for cancer researchers, clinicians, graduate students, and other members of the biomedical field who are interested in learning the most recent and promising treatments for lung cancer.

Key Features: Presents historical context of how NSCLC and SCLC has been treated, with an emphasis on NSCLC, and of how and why EGFR inhibitors have been implemented; Discusses critical biological resistance mechanisms to first-, second-, and third-generation EGFR inhibitors; Encompasses the current state of affairs of clinical trials to address drug resistance.

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