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Research ArticleClinical Studies

Efficacy of Nivolumab and Pembrolizumab in Platinum-sensitive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

GAI YAMASHITA, ISAKU OKAMOTO, TATSUYA ITO, KUNIHIKO TOKASHIKI, TAKURO OKADA and KIYOAKI TSUKAHARA
Anticancer Research August 2023, 43 (8) 3679-3683; DOI: https://doi.org/10.21873/anticanres.16550
GAI YAMASHITA
Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan
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ISAKU OKAMOTO
Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan
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  • For correspondence: isaku{at}tokyo-med.ac.jp
TATSUYA ITO
Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan
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KUNIHIKO TOKASHIKI
Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan
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TAKURO OKADA
Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan
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KIYOAKI TSUKAHARA
Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan
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    Figure 1.

    Study schema.

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    Figure 2.

    Overall-survival (OS) for the whole patient cohort. Median OS is 16.9 months (range=3.1-51.6 months) (95%CI=9.1 months to 20.3 months) in the nivolumab group, and the median OS is 19.2 months (range=1.0-28.3 months) [95% confidence interval (95%CI)=−6.6 months to not calculable (N/C)] in the pembrolizumab group.

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    Figure 3.

    Progression-free survival (PFS) for the whole patient cohort. Median PFS is 4.8 months (range=1.6-51.6 months) [95% confidence interval (95%CI)=2.8 months to not calculable (N/C)] in the nivolumab group. Median OS is 9.3 months (range=1.0-28.3 months) (95%CI=2.2 months to N/C) in the pembrolizumab group.

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Anticancer Research: 43 (8)
Anticancer Research
Vol. 43, Issue 8
August 2023
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Efficacy of Nivolumab and Pembrolizumab in Platinum-sensitive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
GAI YAMASHITA, ISAKU OKAMOTO, TATSUYA ITO, KUNIHIKO TOKASHIKI, TAKURO OKADA, KIYOAKI TSUKAHARA
Anticancer Research Aug 2023, 43 (8) 3679-3683; DOI: 10.21873/anticanres.16550

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Efficacy of Nivolumab and Pembrolizumab in Platinum-sensitive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
GAI YAMASHITA, ISAKU OKAMOTO, TATSUYA ITO, KUNIHIKO TOKASHIKI, TAKURO OKADA, KIYOAKI TSUKAHARA
Anticancer Research Aug 2023, 43 (8) 3679-3683; DOI: 10.21873/anticanres.16550
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Keywords

  • nivolumab
  • pembrolizumab
  • platinum sensitive
  • recurrent or metastatic head and neck squamous cell carcinoma
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