Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues 2025
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

Post-resection Cavity Lavage of High Grade Glioma With a Novel Drug Combination: A Case Report

SIBHI GANAPATHY, NEELAM K. VENKATARAMANA, SHAILESH AV RAO, ANMOL NAGARAJ, GEORGE PANAYOTOU, CHRISTOS PANOTOPOULOS and GUNNAR RONQUIST
Anticancer Research August 2023, 43 (8) 3583-3588; DOI: https://doi.org/10.21873/anticanres.16537
SIBHI GANAPATHY
1Department of Neurosurgery, St. Johns Medical College, Bangalore, India;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
NEELAM K. VENKATARAMANA
2BRAINS Super Speciality Hospital, Bangalore, India;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SHAILESH AV RAO
1Department of Neurosurgery, St. Johns Medical College, Bangalore, India;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
ANMOL NAGARAJ
2BRAINS Super Speciality Hospital, Bangalore, India;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
GEORGE PANAYOTOU
3Biomedical Sciences Research Center “Alexander Fleming”, Vari, Greece;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
CHRISTOS PANOTOPOULOS
2BRAINS Super Speciality Hospital, Bangalore, India;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: chpanot@gmail.com
GUNNAR RONQUIST
4Department of Medical Sciences, Clinical Chemistry, University of Uppsala, Uppsala, Sweden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: gunnar.ronquist@akademiska.se
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

This article has a correction. Please see:

  • Corrigenda - December 01, 2023

Abstract

Background: High grade gliomas are the most common and most lethal primary cancers of the central nervous system. Case Report: We herein present a case report of a long-term surviving 36-year-old female diagnosed with high grade glioma, for which she underwent neurosurgery with a gross total removal of the tumor. Shortly thereafter (<3 months) she was readmitted in a desolate state due to a large recurrence. After Ethical Committee approval, proper explanation, and consent from spouse, she was subjected to a reoperation involving a post-operative infusion into the excised tumor cavity, containing a mixture of a non-physiological amino acid in millimolar concentration and a proapoptotic drug in micromolar concentration. The patient tolerated the treatment well and was discharged in a stable state thereafter. A series of follow ups revealed successive clinical improvements and after 4-6 months, she had recovered with mild left hemiparesis, meaning that she was able to carry out activities of daily living independently. Now, 5.5 years later, after the recurrence and the infusion therapy, she continues to have a mild left hemiparesis and her MRI with contrast shows no evidence of tumor. Conclusion: Continuous intratumoral infusion therapy with an artificial amino acid combined with a proapoptotic drug results in complete glioma cell lysis both in vitro and in vivo.

Key Words:
  • Glioma
  • diaminobutyric acid
  • prazosin
  • drug combination
  • amino acids
  • Received May 31, 2023.
  • Revision received June 27, 2023.
  • Accepted June 28, 2023.
  • Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
View Full Text

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.

patientACCESS

patientACCESS - Patients desiring access to articles
PreviousNext
Back to top

In this issue

Anticancer Research: 43 (8)
Anticancer Research
Vol. 43, Issue 8
August 2023
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Post-resection Cavity Lavage of High Grade Glioma With a Novel Drug Combination: A Case Report
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
16 + 0 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
Post-resection Cavity Lavage of High Grade Glioma With a Novel Drug Combination: A Case Report
SIBHI GANAPATHY, NEELAM K. VENKATARAMANA, SHAILESH AV RAO, ANMOL NAGARAJ, GEORGE PANAYOTOU, CHRISTOS PANOTOPOULOS, GUNNAR RONQUIST
Anticancer Research Aug 2023, 43 (8) 3583-3588; DOI: 10.21873/anticanres.16537

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
Post-resection Cavity Lavage of High Grade Glioma With a Novel Drug Combination: A Case Report
SIBHI GANAPATHY, NEELAM K. VENKATARAMANA, SHAILESH AV RAO, ANMOL NAGARAJ, GEORGE PANAYOTOU, CHRISTOS PANOTOPOULOS, GUNNAR RONQUIST
Anticancer Research Aug 2023, 43 (8) 3583-3588; DOI: 10.21873/anticanres.16537
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Case Report
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

  • Corrigenda
  • PubMed
  • Google Scholar

Cited By...

  • Elimination of High-grade Gliomas Through Induced Cytolysis, Elucidated by Two Patient Cases
  • Google Scholar

More in this TOC Section

  • Tumor Budding Grade and T Stage as Recurrence Predictors of High-risk Stage II Colorectal Cancer
  • Pathologic Complete Response (pCR) in Patient With Myxofibrosarcoma Who Underwent Neoadjuvant Radiation Concurrent to Complementary and Alternative Medicine
  • Machine Learning Model to Guide Empirical Antimicrobial Therapy in Febrile Neutropenic Patients With Hematologic Malignancies
Show more Clinical Studies

Similar Articles

Keywords

  • Glioma
  • diaminobutyric acid
  • prazosin
  • drug combination
  • amino acids
Anticancer Research

© 2025 Anticancer Research

Powered by HighWire