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Research ArticleExperimental Studies

Improved Algorithm for Estimation of Linear Energy Transfer in Carbon Ion Radiotherapy Plans

MAI ANAKURA, YOSHIKI KUBOTA, TAKAHIRO OIKE, AKIHIKO MATSUMURA, MAKOTO SAKAI, NOBUYUKI KANEMATSU, MUTSUMI TASHIRO and TATSUYA OHNO
Anticancer Research July 2023, 43 (7) 2975-2984; DOI: https://doi.org/10.21873/anticanres.16468
MAI ANAKURA
1Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan;
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YOSHIKI KUBOTA
2Gunma University Heavy Ion Medical Center, Gunma, Japan;
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TAKAHIRO OIKE
1Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan;
2Gunma University Heavy Ion Medical Center, Gunma, Japan;
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  • For correspondence: oiketakahiro@gunma-u.ac.jp
AKIHIKO MATSUMURA
2Gunma University Heavy Ion Medical Center, Gunma, Japan;
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MAKOTO SAKAI
2Gunma University Heavy Ion Medical Center, Gunma, Japan;
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NOBUYUKI KANEMATSU
3Department of Accelerator and Medical Physics, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
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MUTSUMI TASHIRO
2Gunma University Heavy Ion Medical Center, Gunma, Japan;
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TATSUYA OHNO
1Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan;
2Gunma University Heavy Ion Medical Center, Gunma, Japan;
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Abstract

Background/Aim: This study aimed to develop an improved algorithm for linear energy transfer (LET) estimation in carbon ion radiotherapy (CIRT) using relative biological effectiveness (RBE) and to establish a clinical pipeline for LET assessment. Materials and Methods: New approximation functions for LET versus RBE were developed for the overkill region. LET estimation performance was examined at two facilities (A and B) using archival- and Monte Carlo simulation-derived LET data, respectively, as a reference. A clinical pipeline for LET assessment was developed using Python and treatment planning systems (TPS). Results: In dataset A, LET estimation accuracy in the overkill region was improved by 80.0%. In dataset B, estimation accuracy was 2.3%±0.67% across 5 data points examined. LET distribution and LET-volume histograms were visualized for multiple CIRT plans. Conclusion: The new algorithm showed a greater LET estimation performance at multiple facilities using the same TPS. A clinical pipeline for LET assessment was established.

Key Words:
  • Carbon ion radiotherapy
  • linear energy transfer
  • estimation
  • relative biological effectiveness
  • treatment planning
  • Received March 18, 2023.
  • Revision received May 6, 2023.
  • Accepted May 8, 2023.
  • Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 43 (7)
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July 2023
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Improved Algorithm for Estimation of Linear Energy Transfer in Carbon Ion Radiotherapy Plans
MAI ANAKURA, YOSHIKI KUBOTA, TAKAHIRO OIKE, AKIHIKO MATSUMURA, MAKOTO SAKAI, NOBUYUKI KANEMATSU, MUTSUMI TASHIRO, TATSUYA OHNO
Anticancer Research Jul 2023, 43 (7) 2975-2984; DOI: 10.21873/anticanres.16468

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Improved Algorithm for Estimation of Linear Energy Transfer in Carbon Ion Radiotherapy Plans
MAI ANAKURA, YOSHIKI KUBOTA, TAKAHIRO OIKE, AKIHIKO MATSUMURA, MAKOTO SAKAI, NOBUYUKI KANEMATSU, MUTSUMI TASHIRO, TATSUYA OHNO
Anticancer Research Jul 2023, 43 (7) 2975-2984; DOI: 10.21873/anticanres.16468
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Keywords

  • carbon ion radiotherapy
  • linear energy transfer
  • estimation
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  • treatment planning
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