Skip to main content

Main menu

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics

User menu

  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Anticancer Research
  • Other Publications
    • Anticancer Research
    • In Vivo
    • Cancer Genomics & Proteomics
  • Register
  • Subscribe
  • My alerts
  • Log in
  • My Cart
Anticancer Research

Advanced Search

  • Home
  • Current Issue
  • Archive
  • Info for
    • Authors
    • Editorial Policies
    • Subscribers
    • Advertisers
    • Editorial Board
    • Special Issues
  • Journal Metrics
  • Other Publications
    • In Vivo
    • Cancer Genomics & Proteomics
    • Cancer Diagnosis & Prognosis
  • More
    • IIAR
    • Conferences
    • 2008 Nobel Laureates
  • About Us
    • General Policy
    • Contact
  • Visit us on Facebook
  • Follow us on Linkedin
Research ArticleClinical Studies

CDX2-positive Cancer of Unknown Primary With Upper-body Paralysis Was Dramatically Improved by Colorectal Cancer Chemotherapy

HIDEKO AKAGI, YUSAKU TANAKA, KOHEI WADA, MIANAMI TAKAHASHI, KOUDAI YOSHIDA and HIDEHARU DOMOTO
Anticancer Research June 2023, 43 (6) 2879-2884; DOI: https://doi.org/10.21873/anticanres.16458
HIDEKO AKAGI
1Department of Oncology, Keiyu Hospital, Yokohama, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: h-akagi{at}keiyu-hosipital.com
YUSAKU TANAKA
2Department of Gastroenterology, Keiyu Hospital, Yokohama, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KOHEI WADA
3Department of Rehabilitation, Keiyu Hospital, Yokohama, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MIANAMI TAKAHASHI
4Department of Palliative Care, Keiyu Hospital, Yokohama, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
KOUDAI YOSHIDA
5Department of Orthopedics, Keiyu Hospital, Yokohama, Japan;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
HIDEHARU DOMOTO
6Department of Pathology, Keiyu Hospital, Yokohama, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Figure 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1.

    Manual muscle test (MMT) of the right and left upper extremities. A) At the initial visit to our hospital, the MMT scores of the deltoid, biceps, and triceps muscles of the right upper extremity were all 5/5. Despite posterior stabilization, muscle weakness in the right upper limb progressed, and the right extremities could hardly move. However, chemotherapy dramatically improved the patient’s muscle weakness. With the continuation of chemotherapy, the movement of the upper right limb gradually improved. The squares represent biceps, the triangles represent triceps, and the arrows represent deltoid. B) At the initial visit to our hospital, the MMT scores of the left deltoid and triceps muscles of the left upper extremity was 2/5, while the score of the left biceps muscle was 1/5. The left upper extremity was originally recognized to have lost muscle strength earlier, and the muscle strength of the left upper extremity took longer to improve in comparison to the muscle strength of the right upper extremity. Nevertheless, chemotherapy gradually improved the movement of his left extremity. The squares represent biceps, the triangles represent triceps, and the arrows represent deltoid.

  • Figure 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2.

    Osteolytic masses extended to the vertebral arch in the C5, C6, C7, and Th3 vertebral bodies (arrow).

  • Figure 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 3.

    Thickening of the sigmoid colon was observed from the rectal area, and the boundary with the surrounding fat was unclear on computed tomography, suggesting colorectal cancer (arrow).

  • Figure 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 4.

    Pathology of colorectal cancer and vertebra. A) Pathology of colorectal cancer. 1. Atypical cells grew in alveolar foci. Glandular formation was unclear, suggesting poorly differentiated adenocarcinoma (HE staining, ×200). 2. Cytokeratin 7 (CK7) negative (CK7 staining). 3. Cytokeratin 20 (CK20) negative (CK20 staining). Most colorectal cancers are CK7-negative and CK20-positive; thus, this case was not typical. B) Pathology of vertebra. 1. The tumor proliferated like an alveolus with some small glandular formations, suggesting moderately to poorly differentiated adenocarcinoma (HE staining, ×200). It was suspected that it was a metastatic lesion, but at this point it was not known where the metastasis came from. 2. CK7 negative (CK7 staining, ×200). 3. CK20 negative (CK20 staining, ×200). Negative results for CK7 and CK20 were consistent with colorectal cancer findings. 4. CDX2 positive. Diffuse nuclear positivity (CK20 staining, ×200). A positive CDX2 resulted in a diagnosis of colorectal cancer.

PreviousNext
Back to top

In this issue

Anticancer Research: 43 (6)
Anticancer Research
Vol. 43, Issue 6
June 2023
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Ed Board (PDF)
  • Front Matter (PDF)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Anticancer Research.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
CDX2-positive Cancer of Unknown Primary With Upper-body Paralysis Was Dramatically Improved by Colorectal Cancer Chemotherapy
(Your Name) has sent you a message from Anticancer Research
(Your Name) thought you would like to see the Anticancer Research web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
5 + 5 =
Solve this simple math problem and enter the result. E.g. for 1+3, enter 4.
Citation Tools
CDX2-positive Cancer of Unknown Primary With Upper-body Paralysis Was Dramatically Improved by Colorectal Cancer Chemotherapy
HIDEKO AKAGI, YUSAKU TANAKA, KOHEI WADA, MIANAMI TAKAHASHI, KOUDAI YOSHIDA, HIDEHARU DOMOTO
Anticancer Research Jun 2023, 43 (6) 2879-2884; DOI: 10.21873/anticanres.16458

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Reprints and Permissions
Share
CDX2-positive Cancer of Unknown Primary With Upper-body Paralysis Was Dramatically Improved by Colorectal Cancer Chemotherapy
HIDEKO AKAGI, YUSAKU TANAKA, KOHEI WADA, MIANAMI TAKAHASHI, KOUDAI YOSHIDA, HIDEHARU DOMOTO
Anticancer Research Jun 2023, 43 (6) 2879-2884; DOI: 10.21873/anticanres.16458
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Case Report
    • Discussion
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Related Articles

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Feasibility of Minimally Invasive Surgery for Locally Advanced Gastric Cancer After Neoadjuvant Chemotherapy: A Four-arm Comparative Study
  • Prior Radiotherapy Improves Progression-free Survival in Patients With Advanced Hepatocellular Carcinoma Treated With Tremelimumab–Durvalumab
  • Optimizing Biopsy Decisions in PI-RADS 3-4 Lesions: Integrating PSA-derived Biomarkers to Reduce Unnecessary Procedures
Show more Clinical Studies

Keywords

  • Caudal-related homeobox transcription factor 2 (CDX2)
  • CRC
  • chemotherapy
  • metastatic spinal tumor
  • spinal cord compression
  • cetuximab
  • manual muscle testing
Anticancer Research

© 2026 Anticancer Research

Powered by HighWire