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Research ArticleClinical Studies

Long-term Outcomes of Early-stage Non-stomach Gastrointestinal Mucosa-associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy

EIKO ITO, ICHIRO OGINO, MADOKA SUGIURA, SHIGENOBU WATANABE, YOSHIBUMI TAYAMA, SHOKO TAKANO and MASAHARU HATA
Anticancer Research June 2023, 43 (6) 2851-2857; DOI: https://doi.org/10.21873/anticanres.16454
EIKO ITO
1Department of Radiation Oncology, Yokohama City University Medical Center, Yokohama, Japan;
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  • For correspondence: e_itoh@yokohama-cu.ac.jp
ICHIRO OGINO
1Department of Radiation Oncology, Yokohama City University Medical Center, Yokohama, Japan;
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MADOKA SUGIURA
2Department of Radiation Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;
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SHIGENOBU WATANABE
3Department of Radiation Oncology, Fujisawa City Hospital, Yokohama, Japan
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YOSHIBUMI TAYAMA
2Department of Radiation Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;
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SHOKO TAKANO
2Department of Radiation Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;
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MASAHARU HATA
2Department of Radiation Oncology, Yokohama City University Graduate School of Medicine, Yokohama, Japan;
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Abstract

Background/Aim: Non-stomach gastrointestinal mucosa-associated lymphoid tissue (MALT) lymphoma is rare, and there are only a few reports regarding radiation therapy (RT) for non-stomach gastrointestinal MALT lymphoma. There has been no established cure and no reports on RT use with long-term follow-up. Herein, we report a retrospective long-term investigation of early-stage non-stomach gastrointestinal MALT lymphoma. Our aim was to evaluate whether RT is a valid treatment option for this disease. Patients and Methods: We retrospectively analyzed 6 patients who were diagnosed with early-stage non-stomach gastrointestinal MALT lymphoma and received RT. The median age was 66 years (range=38-89 years). The primary tumor originated from the duodenum in 2 patients and from the rectum in 4 patients. The RT dose was 30-34 Gy in 15-20 fractions to the involved site or field, depending on the case. Results: The median follow-up time was 89.5 months (range=6-170). All patients had complete remission within 3 months after RT. The 5-year overall survival and progression-free survival rates were 83.3% and 100%, respectively. During the observation period, no patient had a confirmed recurrence. One patient died of causes unrelated to cancer or treatment. There were no late toxicities by RT. Conclusion: Our results show good long-term local control and no late toxicities requiring treatment. Moderate-dose RT was appropriate and well tolerated for early-stage non-stomach gastrointestinal MALT lymphoma.

Key Words:
  • Early-stage MALT lymphoma
  • duodenal MALT lymphoma
  • rectal MALT lymphoma
  • radiation therapy
  • long-term outcomes
  • Received March 30, 2023.
  • Revision received April 15, 2023.
  • Accepted April 21, 2023.
  • Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 43 (6)
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June 2023
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Long-term Outcomes of Early-stage Non-stomach Gastrointestinal Mucosa-associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy
EIKO ITO, ICHIRO OGINO, MADOKA SUGIURA, SHIGENOBU WATANABE, YOSHIBUMI TAYAMA, SHOKO TAKANO, MASAHARU HATA
Anticancer Research Jun 2023, 43 (6) 2851-2857; DOI: 10.21873/anticanres.16454

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Long-term Outcomes of Early-stage Non-stomach Gastrointestinal Mucosa-associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy
EIKO ITO, ICHIRO OGINO, MADOKA SUGIURA, SHIGENOBU WATANABE, YOSHIBUMI TAYAMA, SHOKO TAKANO, MASAHARU HATA
Anticancer Research Jun 2023, 43 (6) 2851-2857; DOI: 10.21873/anticanres.16454
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Keywords

  • Early-stage MALT lymphoma
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  • rectal MALT lymphoma
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  • long-term outcomes
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