Lymph Node Metastasis in Extraperitoneal Rectal Cancer After Neoadjuvant Therapy: An Unsolved Problem?

ALICE LA FRANCA; EDOARDO MARIA MUTTILLO; ISABELLA MADAFFARI; FANNY MASSIMI; GIUSEPPE LONGO; ALICE CECCACCI; ILARIA ANGELICONE; FLAVIA DE GIACOMO; ISABELLA SPERDUTI; GENOVEFFA BALDUCCI; MATTIA FALCHETTO OSTI; PAOLO MERCANTINI

doi:10.21873/anticanres.16450

Research ArticleClinical Studies

Lymph Node Metastasis in Extraperitoneal Rectal Cancer After Neoadjuvant Therapy: An Unsolved Problem?

ALICE LA FRANCA, EDOARDO MARIA MUTTILLO, ISABELLA MADAFFARI, FANNY MASSIMI, GIUSEPPE LONGO, ALICE CECCACCI, ILARIA ANGELICONE, FLAVIA DE GIACOMO, ISABELLA SPERDUTI, GENOVEFFA BALDUCCI, MATTIA FALCHETTO OSTI and PAOLO MERCANTINI

Anticancer Research June 2023, 43 (6) 2813-2820; DOI: https://doi.org/10.21873/anticanres.16450

ALICE LA FRANCA

1Department of Medical Surgical Science and Translational Medicine, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;

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EDOARDO MARIA MUTTILLO

1Department of Medical Surgical Science and Translational Medicine, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;

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For correspondence: edoardomaria.muttillo{at}uniroma1.it

ISABELLA MADAFFARI

1Department of Medical Surgical Science and Translational Medicine, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;

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FANNY MASSIMI

1Department of Medical Surgical Science and Translational Medicine, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;

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GIUSEPPE LONGO

1Department of Medical Surgical Science and Translational Medicine, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;

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ALICE CECCACCI

1Department of Medical Surgical Science and Translational Medicine, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;

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ILARIA ANGELICONE

2Radiotherapy Oncology, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;

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FLAVIA DE GIACOMO

2Radiotherapy Oncology, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;

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ISABELLA SPERDUTI

3Biostatistical Unit – Clinical Trials Center, IRCCS Regina Elena National Cancer Institute, Rome, Italy

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GENOVEFFA BALDUCCI

1Department of Medical Surgical Science and Translational Medicine, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;

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MATTIA FALCHETTO OSTI

2Radiotherapy Oncology, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;

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PAOLO MERCANTINI

1Department of Medical Surgical Science and Translational Medicine, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;

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vol. 43 no. 6 2813-2820

DOI

https://doi.org/10.21873/anticanres.16450

PMID

37247907

Published By

International Institute of Anticancer Research

Print ISSN

0250-7005

Online ISSN

1791-7530

History

Received March 15, 2023
Revision received April 2, 2023
Accepted April 5, 2023
Published online May 29, 2023.

Author Information

ALICE LA FRANCA¹,*,
EDOARDO MARIA MUTTILLO¹ ⇑*,
ISABELLA MADAFFARI¹,
FANNY MASSIMI¹,
GIUSEPPE LONGO¹,
ALICE CECCACCI¹,
ILARIA ANGELICONE²,
FLAVIA DE GIACOMO²,
ISABELLA SPERDUTI³,
GENOVEFFA BALDUCCI¹,
MATTIA FALCHETTO OSTI² and
PAOLO MERCANTINI¹

¹Department of Medical Surgical Science and Translational Medicine, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;
²Radiotherapy Oncology, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy;
³Biostatistical Unit – Clinical Trials Center, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Correspondence to: Edoardo Maria Muttillo, MD, Department of Medical Surgical Science and Translational Medicine, Sant’ Andrea Hospital, Sapienza University of Rome, Rome, Italy. Tel.: +39 3345451425, e-mail: edoardomaria.muttillo{at}uniroma1.it

↵* These Authors contributed equally to this study.

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Lymph Node Metastasis in Extraperitoneal Rectal Cancer After Neoadjuvant Therapy: An Unsolved Problem?

Anticancer Research Jun 2023, 43 (6) 2813-2820; DOI: 10.21873/anticanres.16450

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Lymph Node Metastasis in Extraperitoneal Rectal Cancer After Neoadjuvant Therapy: An Unsolved Problem?

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Keywords

Rectal cancer
organ-sparing surgery
lymph node metastasis
watch and wait
neoadjuvant chemoradiotherapy
complete pathological response
clinical complete response

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