11-epi-Sinulariolide Acetate-induced Apoptosis in Oral Cancer Cells Is Regulated by FOXO Through Inhibition of PI3K/AKT Pathway

TING-SHOU CHANG; JEN-JIE LIN; KAI-CHUN CHENG; JUI-HSIN SU; YUN-YING SHE; YU-JEN WU

doi:10.21873/anticanres.16429

Research ArticleExperimental Studies

11-epi-Sinulariolide Acetate-induced Apoptosis in Oral Cancer Cells Is Regulated by FOXO Through Inhibition of PI3K/AKT Pathway

TING-SHOU CHANG, JEN-JIE LIN, KAI-CHUN CHENG, JUI-HSIN SU, YUN-YING SHE and YU-JEN WU

Anticancer Research June 2023, 43 (6) 2625-2634; DOI: https://doi.org/10.21873/anticanres.16429

TING-SHOU CHANG

1Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.;

2School of Medicine, National Defense Medical Center, Taipei, Taiwan, R.O.C.;

3Institute of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.;

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JEN-JIE LIN

4Yu Jun Biotechnology Co., Ltd., Kaohsiung, Taiwan, R.O.C.;

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KAI-CHUN CHENG

5Department of Ophthalmology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan, R.O.C.;

6Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.;

7Department of Ophthalmology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;

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JUI-HSIN SU

8National Museum of Marine Biology and Aquarium, Pingtung, Taiwan, R.O.C.;

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YUN-YING SHE

1Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.;

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YU-JEN WU

4Yu Jun Biotechnology Co., Ltd., Kaohsiung, Taiwan, R.O.C.;

9Department of Food and Nutrition, Meiho University, Pingtung, Taiwan, R.O.C.

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For correspondence: x00002180@meiho.edu.tw

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Anticancer Research

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11-epi-Sinulariolide Acetate-induced Apoptosis in Oral Cancer Cells Is Regulated by FOXO Through Inhibition of PI3K/AKT Pathway

TING-SHOU CHANG, JEN-JIE LIN, KAI-CHUN CHENG, JUI-HSIN SU, YUN-YING SHE, YU-JEN WU

Anticancer Research Jun 2023, 43 (6) 2625-2634; DOI: 10.21873/anticanres.16429

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11-epi-Sinulariolide Acetate-induced Apoptosis in Oral Cancer Cells Is Regulated by FOXO Through Inhibition of PI3K/AKT Pathway

TING-SHOU CHANG, JEN-JIE LIN, KAI-CHUN CHENG, JUI-HSIN SU, YUN-YING SHE, YU-JEN WU

Anticancer Research Jun 2023, 43 (6) 2625-2634; DOI: 10.21873/anticanres.16429

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Keywords

11-epi-sinulariolide acetate
oral squamous cell carcinoma
Sinularia flexibilis
PI3K/AKT/FOXO
apoptosis

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