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Research ArticleExperimental Studies

11-epi-Sinulariolide Acetate-induced Apoptosis in Oral Cancer Cells Is Regulated by FOXO Through Inhibition of PI3K/AKT Pathway

TING-SHOU CHANG, JEN-JIE LIN, KAI-CHUN CHENG, JUI-HSIN SU, YUN-YING SHE and YU-JEN WU
Anticancer Research June 2023, 43 (6) 2625-2634; DOI: https://doi.org/10.21873/anticanres.16429
TING-SHOU CHANG
1Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.;
2School of Medicine, National Defense Medical Center, Taipei, Taiwan, R.O.C.;
3Institute of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.;
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JEN-JIE LIN
4Yu Jun Biotechnology Co., Ltd., Kaohsiung, Taiwan, R.O.C.;
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KAI-CHUN CHENG
5Department of Ophthalmology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan, R.O.C.;
6Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.;
7Department of Ophthalmology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
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JUI-HSIN SU
8National Museum of Marine Biology and Aquarium, Pingtung, Taiwan, R.O.C.;
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YUN-YING SHE
1Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.;
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YU-JEN WU
4Yu Jun Biotechnology Co., Ltd., Kaohsiung, Taiwan, R.O.C.;
9Department of Food and Nutrition, Meiho University, Pingtung, Taiwan, R.O.C.
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  • For correspondence: x00002180@meiho.edu.tw
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Article Information

vol. 43 no. 6 2625-2634
DOI 
https://doi.org/10.21873/anticanres.16429
PubMed 
37247910

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received March 27, 2023
  • Revision received April 8, 2023
  • Accepted April 10, 2023
  • Published online May 29, 2023.

Copyright & Usage 
Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. TING-SHOU CHANG1,2,3,
  2. JEN-JIE LIN4,
  3. KAI-CHUN CHENG5,6,7,
  4. JUI-HSIN SU8,
  5. YUN-YING SHE1 and
  6. YU-JEN WU4,9⇑
  1. 1Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R.O.C.;
  2. 2School of Medicine, National Defense Medical Center, Taipei, Taiwan, R.O.C.;
  3. 3Institute of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.;
  4. 4Yu Jun Biotechnology Co., Ltd., Kaohsiung, Taiwan, R.O.C.;
  5. 5Department of Ophthalmology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan, R.O.C.;
  6. 6Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, R.O.C.;
  7. 7Department of Ophthalmology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
  8. 8National Museum of Marine Biology and Aquarium, Pingtung, Taiwan, R.O.C.;
  9. 9Department of Food and Nutrition, Meiho University, Pingtung, Taiwan, R.O.C.
  1. Correspondence to: Yu-Jen Wu, Department of Food Science and Nutrition, Mei-ho University, Pingguang Rd., No. 23, 91202, Pingtung, Taiwan, R.O.C. Tel: +886 87799821 (ext. 8105), Fax: +886 87797821, e-mail: x00002180{at}meiho.edu.tw
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11-epi-Sinulariolide Acetate-induced Apoptosis in Oral Cancer Cells Is Regulated by FOXO Through Inhibition of PI3K/AKT Pathway
TING-SHOU CHANG, JEN-JIE LIN, KAI-CHUN CHENG, JUI-HSIN SU, YUN-YING SHE, YU-JEN WU
Anticancer Research Jun 2023, 43 (6) 2625-2634; DOI: 10.21873/anticanres.16429

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11-epi-Sinulariolide Acetate-induced Apoptosis in Oral Cancer Cells Is Regulated by FOXO Through Inhibition of PI3K/AKT Pathway
TING-SHOU CHANG, JEN-JIE LIN, KAI-CHUN CHENG, JUI-HSIN SU, YUN-YING SHE, YU-JEN WU
Anticancer Research Jun 2023, 43 (6) 2625-2634; DOI: 10.21873/anticanres.16429
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Keywords

  • 11-epi-sinulariolide acetate
  • oral squamous cell carcinoma
  • Sinularia flexibilis
  • PI3K/AKT/FOXO
  • apoptosis
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