Table of Contents

Clinical Studies

• Open Access

  A Phase I/II Investigation of Safety and Efficacy of Nivolumab and nab-Sirolimus in Patients With a Variety of Tumors With Genetic Mutations in the mTOR Pathway

  ERLINDA M. GORDON, NICOLE L. ANGEL, NADEZHDA OMELCHENKO, VICTORIA S. CHUA-ALCALA, ANIA MORADKHANI, DORIS QUON and STEVEN WONG

  Anticancer Research May 2023, 43 (5) 1993-2002; DOI: https://doi.org/10.21873/anticanres.16360
• Open Access

  Long-term Outcomes After Moderate Hypofractionated Proton Therapy for Centrally Located Non-small Cell Lung Cancer

  MASATOSHI NAKAMURA, HITOSHI ISHIKAWA, KAYOKO OHNISHI, KEIICHIRO BABA, TAISUKE SUMIYA, MOTOHIRO MURAKAMI, YUICHI HIROSHIMA, MASASHI MIZUMOTO, TOSHIYUKI OKUMURA and HIDEYUKI SAKURAI

  Anticancer Research May 2023, 43 (5) 2003-2013; DOI: https://doi.org/10.21873/anticanres.16361
• Open Access

  Prognostic Impact of Ras Mutation on Surgical Strategy in Rectal Cancer Patients Undergoing Neoadjuvant Treatment

  ELENA ORLANDI, ANDREA ROMBOLI, CHIARA CITTERIO, SERENA TRUBINI, STEFANO VECCHIA, MARIA ANGELA PALLADINO, PATRIZIO CAPELLI and LUIGI CAVANNA

  Anticancer Research May 2023, 43 (5) 2015-2024; DOI: https://doi.org/10.21873/anticanres.16362
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  Nowarta110 Topical Versus Placebo for the Treatment of Plantar Warts: A Phase I/II Randomized Controlled Clinical Trial

  MAHKAMEH YOUSEFPOUR, IRAJ ZAMANIAN, FERRE AKBARPOUR, WILLIAM H. FANG, BO HAN and BA X. HOANG

  Anticancer Research May 2023, 43 (5) 2025-2030; DOI: https://doi.org/10.21873/anticanres.16363
• Open Access

  Exploring the Patient Perspective of Bone Sarcoma Survivors Who Have Undergone Particle Radiotherapy Abroad

  LENA FAUSKE, NINA L. JEBSEN, HILDE BONDEVIK and ØYVIND S. BRULAND

  Anticancer Research May 2023, 43 (5) 2031-2039; DOI: https://doi.org/10.21873/anticanres.16364
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  Helical Tomotherapy of Lymph Node-negative Early-stage Breast Cancer After Breast-conserving Surgery: Long-term Results

  FELIX ZWICKER, RUDOLF KLEPPER, HENRIK HAUSWALD, SEBASTIAN HOEFEL, LUIS RAETHER, PETER E. HUBER, JUERGEN DEBUS and MICHAEL SCHEMPP

  Anticancer Research May 2023, 43 (5) 2041-2053; DOI: https://doi.org/10.21873/anticanres.16365
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  Survival Benefits of Laparoscopic Gastrectomy in Elderly Patients With Gastric Cancer: Focusing on Preoperative Nutritional and Inflammatory Status

  SHUHEI ITO, KIPPEI OHGAKI, TETSURO KAWAZOE, SHOTA SATO, SHUNJI IKEDA, KEISEI KAKIZOE, HUANLIN WANG, TOSHIHIKO NAKAMURA, SHINICHIRO MAEHARA, EISUKE ADACHI, YOICHI IKEDA and YOSHIHIKO MAEHARA

  Anticancer Research May 2023, 43 (5) 2055-2067; DOI: https://doi.org/10.21873/anticanres.16366
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  Tumor DNA in Peritoneal Lavage as a Novel Biomarker for Predicting Peritoneal Recurrence in Patients With Gastric Cancer

  NORIO YUKAWA, TAKESHI YAMADA, TORU AOYAMA, TEKKAN WOO, KOJI UEDA, AKIHISA MASTUDA, KENTARO HARA, KEISUKE KAZAMA, HIROSHI TAMAGAWA, TSUTOMU SATO, TAKASHI OSHIMA, AKIHIRO SUZUKI, HIROYUKI ABURATANI, SHUMPEI ISHIKAWA, AYA SAITO, MUNETAKA MASUDA, HIROSHI YOSHIDA and YASUSHI RINO

  Anticancer Research May 2023, 43 (5) 2069-2076; DOI: https://doi.org/10.21873/anticanres.16367
• Open Access

  CD8-positive Tumor-infiltrating Lymphocytes and Prognosis in Radiotherapy for Uterine Cervical Squamous Cell Carcinoma

  YUHEI MIYASAKA, YUYA YOSHIMOTO, KEN ANDO, KAZUTOSHI MURATA, DAISUKE IRIE, HIRO SATO, SHIN-EI NODA, HAYATO IKOTA, TAKASHI NAKANO, HIDEAKI YOKOO and TATSUYA OHNO

  Anticancer Research May 2023, 43 (5) 2077-2084; DOI: https://doi.org/10.21873/anticanres.16368
• Open Access

  Relationship Between Safety and Cumulative Bevacizumab Dose in Patients With Metastatic Colorectal Cancer Who Received Long-term Bevacizumab Treatment

  SATOSHI FUKUDA, YUSUKE NIISATO, MIKI TSUJI, SOMA FUKUDA, YUYA HAGIWARA, TSUBASA ONODA, HIROSUMI SUZUKI, YOSHITAKA TANGE, TAKESHI YAMADA, YOSHIYUKI YAMAMOTO and TOSHIKAZU MORIWAKI

  Anticancer Research May 2023, 43 (5) 2085-2090; DOI: https://doi.org/10.21873/anticanres.16369
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  Comprehensive Genomic Profiling Detects Hereditary Cancers and Confers Survival Advantage in Patients With Gynaecological Cancers

  TOMOKO UEDA, HIROSHI TSUBAMOTO, YUMI TAKIMOTO, ROZE ISONO-TANIGUCHI, SACHIYO NARITA, KOHEI NAKAGAWA, YU WAKIMOTO, YUMIKO NISHIMURA, YOSHIKO MUROI, MASAYUKI NAGAHASHI, SEIICHI HIROTA, HIDEAKI SAWAI and HIROAKI SHIBAHARA

  Anticancer Research May 2023, 43 (5) 2091-2101; DOI: https://doi.org/10.21873/anticanres.16370
• Open Access

  Prevalence and Risk Factors of Emotional Distress in Patients With Prostate Cancer Assigned to External-beam Radiotherapy With or Without High-dose Rate Brachytherapy

  AHMED AL-SALOOL, TAMER SOROR, NATHAN Y. YU and DIRK RADES

  Anticancer Research May 2023, 43 (5) 2103-2109; DOI: https://doi.org/10.21873/anticanres.16371
• Open Access

  Prevalence of and Risk Factors for Emotional Distress in Patients Undergoing Radiotherapy for Lung Cancer

  DIRK RADES, AHMED AL-SALOOL, SABINE BOHNET and NATHAN Y. YU

  Anticancer Research May 2023, 43 (5) 2111-2118; DOI: https://doi.org/10.21873/anticanres.16372
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  Efficacy and Tolerability of Second-line Pembrolizumab With Radiation Therapy in Advanced Urothelial Carcinoma

  TAKESHI SANO, RIHITO AIZAWA, KATSUHIRO ITO, KIYONAO NAKAMURA, TAKASHI OGATA, MASASHI TAKEDA, AKIHIRO HAMADA, TAKASHI MATSUOKA, JIN KONO, YUKI KITA, KIMIHIKO MASUI, TAKAYUKI GOTO, ATSURO SAWADA, SHUSUKE AKAMATSU, OSAMU OGAWA, TAKASHI MIZOWAKI and TAKASHI KOBAYASHI

  Anticancer Research May 2023, 43 (5) 2119-2126; DOI: https://doi.org/10.21873/anticanres.16373
• Open Access

  Clinical Benefits of LigaSure™ for Surgical Amputation Without Tourniquet Use in Patients With Musculoskeletal Tumor

  MARTIN LOUIE S. BANGCOY, SHINJI MIWA, NORIO YAMAMOTO, KATSUHIRO HAYASHI, AKIHIKO TAKEUCHI, KENTARO IGARASHI, YUTA TANIGUCHI, SEI MORINAGA, YOHEI ASANO and HIROYUKI TSUCHIYA

  Anticancer Research May 2023, 43 (5) 2127-2133; DOI: https://doi.org/10.21873/anticanres.16374
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  Vacuum-assisted Evacuation (VAEv) of Symptomatic and/or Voluminous Breast Haematomas Following Surgeries and Percutaneous Procedures

  ROSARIA MEUCCI, ORESTE CLAUDIO BUONOMO, TOMMASO PERRETTA, GUGLIELMO MANENTI, GIANLUCA VANNI, ELEONORA LOMBARDO, MARIA LINA SERIO, FRANCESCA DI PIETRO, MARCO PELLICCIARO, FRANCESCA MONTESANTO, CHIARA PALOMBI, FLAVIA RUFI, MARCO MATERAZZO and CHIARA ADRIANA PISTOLESE

  Anticancer Research May 2023, 43 (5) 2135-2143; DOI: https://doi.org/10.21873/anticanres.16375
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  Clinical Significance of Cancer Stem Cell Markers in Primary and Metastatic Tissues in Patients With Breast Cancer

  TAKASHI YAMANAKA, TAKASHI OSHIMA, DAISUKE MURAYAMA, SAKI OKAMOTO, AI MATSUI, MIO YASUKAWA, YUKA MATSUBARA, SOJI TODA, YUKIHIKO HIROSHIMA, TORU AOYAMA, NOBUYASU SUGANUMA, YASUSHI RINO, AYA SAITO, YOHEI MIYAGI, HIROYUKI IWASAKI and TOSHINARI YAMASHITA

  Anticancer Research May 2023, 43 (5) 2145-2154; DOI: https://doi.org/10.21873/anticanres.16376
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  Moderately Hypofractionated Radio(chemo)therapy With Simultaneous Integrated Boost for Recurrent, Previously Irradiated, High-grade Glioma

  PASCAL GRAEN, HANS CHRISTIANSEN, MANOLIS POLEMIKOS, CONSTANTIN HEETFELD, FRIEDRICH FEUERHAKE, BETTINA WIESE and ROLAND MERTEN

  Anticancer Research May 2023, 43 (5) 2155-2160; DOI: https://doi.org/10.21873/anticanres.16377
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  Reducing the Use of Frozen Section for Sentinel Node Biopsy in Breast Carcinoma: Feasibility and Outcome

  TOMMASO SUSINI, ILARIA NESI, IRENE RENDA, MILO GIANI, JACOPO NORI, ERMANNO VANZI and SIMONETTA BIANCHI

  Anticancer Research May 2023, 43 (5) 2161-2170; DOI: https://doi.org/10.21873/anticanres.16378
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  Dorsal Subcutaneous Fat Thickness as a Risk Factor for Pancreatic Fistula After Gastric Cancer Surgery

  HIRONARI MIYAMOTO, MAMI YOSHII, HIROAKI TANAKA, SATOSHI NISHI, SOTA DEGUCHI, YUICHIRO MIKI, TATSURO TAMURA, TAKAHIRO TOYOKAWA, SHIGERU LEE and KIYOSHI MAEDA

  Anticancer Research May 2023, 43 (5) 2171-2178; DOI: https://doi.org/10.21873/anticanres.16379
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  New Scale Predicting Distant Recurrence in Locally Advanced Lower Rectal Cancer Patients After Neoadjuvant Chemoradiotherapy

  RYOSUKE NAKAGAWA, TSUTOMU KUMAMOTO, FUMI MAEDA, KIMITAKA TANI, HIROKA KONDO, KURODO KOSHINO, YUKA KANEKO, YOSHIKO BAMBA, SHIMPEI OGAWA, YUJI INOUE, MICHIO ITABASHI and SHIGEKI YAMAGUCHI

  Anticancer Research May 2023, 43 (5) 2179-2184; DOI: https://doi.org/10.21873/anticanres.16380
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  Influence of Smoking History on the Effectiveness of Immune-checkpoint Inhibitor Therapy for Non-small Cell Lung Cancer: Analysis of Real-world Data

  KENJI NAKAHAMA, MOTOHIRO IZUMI, NAOKI YOSHIMOTO, MITSURU FUKUI, AKIRA SUGIMOTO, HIROAKI NAGAMINE, KOICHI OGAWA, KENJI SAWA, YOKO TANI, HIROYASU KANEDA, SHIGEKI MITSUOKA, TETSUYA WATANABE, KAZUHISA ASAI and TOMOYA KAWAGUCHI

  Anticancer Research May 2023, 43 (5) 2185-2197; DOI: https://doi.org/10.21873/anticanres.16381
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  The Suppressive Effect of NF-kB Activation After Eicosapentaenoic Acid Intake Before Surgery

  HISAKO KUBOTA, TOSHIHIRO HIRAI, AYAKO OGO, HIDEO MATSUMOTO, MASAHARU HIGASHIDA, SHUNJI ENDO, YOSHINORI FUJIWARA and TOMIO UENO

  Anticancer Research May 2023, 43 (5) 2199-2202; DOI: https://doi.org/10.21873/anticanres.16382
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  Clinical Impact of Laparoscopic Surgery on the Long-term Survival of Advanced Gastric Cancer Patients With Regard to Facilitating Doublet Adjuvant Chemotherapy

  KOSHIRO MORINO, MICHIHIRO YAMAMOTO, RYOSUKE YAMANAKA, YUTA IWASAKI, NOZOMU NAKANISHI, TOSHIHIKO GOTO, HIROKAZU TANAKA, RYO MATSUSUE and TAKAFUMI MACHIMOTO

  Anticancer Research May 2023, 43 (5) 2203-2209; DOI: https://doi.org/10.21873/anticanres.16383
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  Transanal Total Mesorectal Excision for Extended Surgery in the Early Stage After Introduction

  SHUNJIN RYU, TAKAHIRO KITAGAWA, KEISUKE GOTO, ATSUSHI NAGASHIMA, TAKEHIRO KOBAYASHI, JUNICHI SHIMADA, RYUSUKE ITO and YUKIO NAKABAYASHI

  Anticancer Research May 2023, 43 (5) 2211-2217; DOI: https://doi.org/10.21873/anticanres.16384
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  N2 Lymph Node Metastasis Is a Useful Predictor of Recurrence in Patients With Stage III Rectal Cancer Undergoing Adjuvant Chemotherapy Using Tegafur–uracil/leucovorin

  SHOTARO MIYASHITA, TAKAYUKI SHIMIZU, MITSURU ISHIZUKA, MAIKO NIKI, YUSUKE NISHI, NORISUKE SHIBUYA, HIROYUKI HACHIYA, TAKATSUGU MATSUMOTO, YUHKI SAKURAOKA, TAKAYUKI SHIRAKI, SHOZO MORI, YUKIHIRO ISO, ATSUSHI IRISAWA and TAKU AOKI

  Anticancer Research May 2023, 43 (5) 2219-2225; DOI: https://doi.org/10.21873/anticanres.16385
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  Emotional Distress in Head-and-neck Cancer Patients Scheduled for Chemoradiation or Radiotherapy Alone

  AHMED AL-SALOOL, TAMER SOROR, NATHAN Y. YU, CHRISTIAN IDEL, KARL L. BRUCHHAGE, SAMER G. HAKIM and DIRK RADES

  Anticancer Research May 2023, 43 (5) 2227-2233; DOI: https://doi.org/10.21873/anticanres.16386
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  Breast Cancer and SARS-Cov2: Lessons from a Pandemic

  MARIE GOSSET, JOCELYN GAL, RENAUD SCHIAPPA, CHRISTOPHER HELWIG, IRIS BONOMO, YANN DELPECH and EMMANUEL BARRANGER

  Anticancer Research May 2023, 43 (5) 2235-2241; DOI: https://doi.org/10.21873/anticanres.16387
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  Clinical Outcomes Beyond 1L EGFR-TKI Progression in mNSCLC: Final Results of the Real-World Study ‘LUNGFUL’

  GIANNIS MOUNTZIOS, ANNA KOUMARIANOU, HELENA LINARDOU, ANASTASIOS BOUTIS, DIMITRIOS MAVROUDIS, EPAMINONDAS SAMANTAS, IPPOKRATIS KORANTZIS, ELIAS ATHANASIADIS, EVANGELOS G. FERGADIS, SOFIA LAMPAKI, VASSILIS GEORGOULIAS, SOFIA BAKA, MICHALIS V. KARAMOUZIS, IOANNIS BOUKOVINAS, CHARALAMPOS ANDREADIS, AGGELIKI RAPTI, NIKOLAOS KOULOURIS, GEORGE PENTHEROUDAKIS, MARIOS E. FROUDARAKIS, ALVERTOS SOMARAKIS, ELEFTHERIA ANASTASOPOULOU, ALEXANDRA KARADIMOU, FOTEINI PAPAGEORGIOU, ZOE PAPAREPA, ARISTEIDIS NIKOLAOU, CHRISTINA PAPISTA and KONSTANTINOS N. SYRIGOS

  Anticancer Research May 2023, 43 (5) 2243-2258; DOI: https://doi.org/10.21873/anticanres.16388
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  In Vivo Dosimetry in the Urethra During Prostate Carbon Ion Radiotherapy

  SHINNOSUKE MATSUMOTO, NARUHIRO MATSUFUJI, YUSUKE KOBA and HIROSHI TSUJI

  Anticancer Research May 2023, 43 (5) 2259-2264; DOI: https://doi.org/10.21873/anticanres.16389
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  Effectiveness of Spacers in Brachytherapy With ¹⁹⁸Au Grains for Patients With Buccal Mucosa Cancer

  MASARU KONISHI, JUNICHI HIROKAWA, SHOTA MIYOSHI, TSUYOSHI KATSUTA, NOBUKI IMANO, IKUNO NISHIBUCHI, YUJI MURAKAMI, KIICHI SHIMABUKURO, TAKEO NAKASHIMA, YUKI TAKEUCHI, NAOYA KAKIMOTO and YASUSHI NAGATA

  Anticancer Research May 2023, 43 (5) 2265-2271; DOI: https://doi.org/10.21873/anticanres.16390
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  Laparoscopic Liver Resection Procedure Attenuates Organ-space Surgical Site Infection Compared With Open Procedure: A Propensity Score-matched Analysis

  KENICHIRO ARAKI, NORIFUMI HARIMOTO, AKIRA WATANABE, MARIKO TSUKAGOSHI, NORIHIRO ISHII, KEI HAGIWARA, RYO MURANUSHI, KOUKI HOSHINO, TAKAOMI SEKI and KEN SHIRABE

  Anticancer Research May 2023, 43 (5) 2273-2280; DOI: https://doi.org/10.21873/anticanres.16391
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  Epithelial-mesenchymal Transition Factor and Its Association With Mammographic Density and Breast Cancer Prognosis

  EUN YOUNG KIM and SANGJEONG AHN

  Anticancer Research May 2023, 43 (5) 2281-2292; DOI: https://doi.org/10.21873/anticanres.16392
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  Efficacy and Cost-effectiveness of Pegfilgrastim for Preventing Febrile Neutropenia During Docetaxel, Cisplatin, and 5-Fluorouracil Therapy for Esophageal Cancer

  TAKANORI KUROGOCHI, AKIRA MATSUMOTO, YUYA NYUMURA, YUICHIRO TANISHIMA, TOMOKO NAKAYOSHI, TOMOYOSHI OKAMOTO, FUMIAKI YANO and KEN ETO

  Anticancer Research May 2023, 43 (5) 2293-2298; DOI: https://doi.org/10.21873/anticanres.16393
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  Prognostic Impact of Malnutrition Diagnosed by the GLIM Criteria for Resected Extrahepatic Cholangiocarcinoma

  YUKI OKAZOE, HIROAKI YANAGIMOTO, DAISUKE TSUGAWA, MASAYUKI AKITA, RIKI ASAKURA, SATOSHI OMIYA, TAKESHI URADE, YOSHIHIDE NANNO, KENJI FUKUSHIMA, HIDETOSHI GON, SHOHEI KOMATSU, KAORI KURAMITSU, TADAHIRO GOTO, SADAKI ASARI, HIROCHIKA TOYAMA, MASAHIRO KIDO, TETSUO AJIKI and TAKUMI FUKUMOTO

  Anticancer Research May 2023, 43 (5) 2299-2308; DOI: https://doi.org/10.21873/anticanres.16394
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  Poor Renal Function and a High Modified Glasgow Prognostic Score Are Predictive Factors for Nedaplatin/5-Fluorouracil Combination Therapy-induced Febrile Neutropenia

  JUNYA HASHIZUME, MADOKA NAMBU, HIROO NAKAGAWA, HITOMI HARASAWA and YUKINOBU KODAMA

  Anticancer Research May 2023, 43 (5) 2309-2316; DOI: https://doi.org/10.21873/anticanres.16395
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  Does Multidisciplinary Therapy at a Sarcoma Center Improve the Prognosis of Patients With Soft Tissue Sarcoma? A Retrospective Case Study at a Single Institute

  TSUKASA YONEMOTO, HIROTO KAMODA, YOKO HAGIWARA and HIDEYUKI KINOSHITA

  Anticancer Research May 2023, 43 (5) 2317-2321; DOI: https://doi.org/10.21873/anticanres.16396
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  Clinicopathological Significance and Predictive Value of High Intratumoral Tumor Budding in Patients With Breast Carcinoma Treated With Neoadjuvant Chemotherapy

  JINAH CHU, HYUN-SOO KIM and SUNG-IM DO

  Anticancer Research May 2023, 43 (5) 2323-2332; DOI: https://doi.org/10.21873/anticanres.16397
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  Elevated Preoperative Serum Vascular Endothelial Growth Factor Does Not Predict Poor Outcomes in Curatively Resected Non-metastatic Colorectal Cancer Treated Without Neoadjuvant Therapy

  NOZOMU NAKAI, ANRI MAEDA, TAKESHI YANAGITA, TAKUYA SUZUKI, YUZO MAEDA, TAKAHISA HIROKAWA, KAZUYOSHI SHIGA, MASAYASU HARA, HIROKI TAKAHASHI, RYO OGAWA, YOICHI MATSUO and SHUJI TAKIGUCHI

  Anticancer Research May 2023, 43 (5) 2333-2341; DOI: https://doi.org/10.21873/anticanres.16398
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  Dual Biomarker Combining DNA Damage Repair Gene Mutations and PD-L1 Expression for Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer

  HYERA KIM, DONG HYUN LIM, YONG SHIK KWON, MI AE KIM and KEON UK PARK

  Anticancer Research May 2023, 43 (5) 2343-2349; DOI: https://doi.org/10.21873/anticanres.16399
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  Emetogenicity and Risk Factors of Nausea and Vomiting in Patients With Metastatic Colorectal Cancer Receiving Trifluridine/Tipiracil and Bevacizumab Chemotherapy

  SERIKA MATSUOKA, HIRONORI FUJII, HIROTOSHI IIHARA, KOICHI OHATA, CHIEMI HIROSE, DAICHI WATANABE, SHIORI SADAKA, SHIGERU KIYAMA, AKITAKA MAKIYAMA, TAKAO TAKAHASHI, RYO KOBAYASHI, NOBUHISA MATSUHASHI and AKIO SUZUKI

  Anticancer Research May 2023, 43 (5) 2351-2357; DOI: https://doi.org/10.21873/anticanres.16400
• Open Access

  Liver Metastases of Unknown Primary Renal Cell Carcinoma Treated With Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors: A Case Report and Literature Review

  DAVIDE BIMBATTI, NICOLÒ CAVASIN, FRANCESCA GALUPPINI, ALESSANDRO RAGO, GAETANO RAMONDO, ELEONORA LAI, MICHELE DIONESE, ELISA ERBETTA, UMBERTO BASSO and MARCO MARUZZO

  Anticancer Research May 2023, 43 (5) 2359-2365; DOI: https://doi.org/10.21873/anticanres.16401
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  Metastatic Adenocarcinoma of the Lung Presenting as a Presternal Cutaneous Mass: Case Report and Brief Literature Review

  HASNA KERROUCH, MARIE DANSET, NAOUFAL HJIRA and JEAN KANITAKIS

  Anticancer Research May 2023, 43 (5) 2367-2370; DOI: https://doi.org/10.21873/anticanres.16402
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  Successful Prevention of Tumour Lysis Syndrome in HER2-positive Breast Cancer: Case Report and Literature Review

  SACHIE OMORI, TOMOKO SHIGECHI, KANA KAWAGUCHI, HIDEKI IJICHI, EIJI OKI and TOMOHARU YOSHIZUMI

  Anticancer Research May 2023, 43 (5) 2371-2377; DOI: https://doi.org/10.21873/anticanres.16403