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Research ArticleClinical Studies

Elevated Preoperative Serum Vascular Endothelial Growth Factor Does Not Predict Poor Outcomes in Curatively Resected Non-metastatic Colorectal Cancer Treated Without Neoadjuvant Therapy

NOZOMU NAKAI, ANRI MAEDA, TAKESHI YANAGITA, TAKUYA SUZUKI, YUZO MAEDA, TAKAHISA HIROKAWA, KAZUYOSHI SHIGA, MASAYASU HARA, HIROKI TAKAHASHI, RYO OGAWA, YOICHI MATSUO and SHUJI TAKIGUCHI
Anticancer Research May 2023, 43 (5) 2333-2341; DOI: https://doi.org/10.21873/anticanres.16398
NOZOMU NAKAI
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
2Department of Surgery, Toyokawa City Hospital, Toyokawa, Japan
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  • For correspondence: nozomu1981@gmail.com
ANRI MAEDA
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
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TAKESHI YANAGITA
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
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TAKUYA SUZUKI
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
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YUZO MAEDA
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
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TAKAHISA HIROKAWA
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
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KAZUYOSHI SHIGA
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
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MASAYASU HARA
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
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HIROKI TAKAHASHI
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
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RYO OGAWA
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
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YOICHI MATSUO
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
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SHUJI TAKIGUCHI
1Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School, Nagoya, Japan;
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Abstract

Background/Aim: Vascular endothelial growth factor (VEGF) influences colorectal cancer (CRC) progression and is a key target in the treatment for metastatic CRC. However, the oncological impact of preoperative circulating VEGF in non-metastatic CRC (non-mCRC) has not been clearly elucidated. Herein, we have investigated the prognostic significance of elevated preoperative serum VEGF concentration in curatively resected non-mCRC without neoadjuvant therapy. Patients and Methods: A total of 474 patients with pStage I-III CRC who underwent curative resection without neoadjuvant therapy were included. The relationship between preoperative serum VEGF concentration and clinicopathologic characteristics, overall survival (OS), and recurrence-free survival (RFS) were investigated. Results: The median follow-up duration was 47.4 months. No significant relationship between preoperative VEGF and clinicopathologic characteristics including tumor markers, pStage, and lymphovascular invasion was identified; however, VEGF values were wide-ranged in every pStage. Patients were categorized into four groups as follows: VEGF < median, median to 75th percentile, 75th percentile to 90th percentile, and ≥90th percentile. A tendency for a difference in 5-year OS (p=0.064) and RFS (p=0.089) was observed among the groups; however, OS and RFS were not correlated with VEGF elevation. In multivariate analyses, VEGF ≥90th percentile was paradoxically associated with better RFS. Conclusion: Preoperative elevated serum VEGF concentration was associated with neither worse clinicopathological characteristics nor worse long-term outcomes in curatively resected non-mCRC. The prognostic value of preoperative circulating VEGF in initially resectable non-mCRC remains limited.

Key Words:
  • Non-metastatic colorectal cancer
  • vascular endothelial growth factor
  • Received February 12, 2023.
  • Revision received February 22, 2023.
  • Accepted February 23, 2023.
  • Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 43 (5)
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Elevated Preoperative Serum Vascular Endothelial Growth Factor Does Not Predict Poor Outcomes in Curatively Resected Non-metastatic Colorectal Cancer Treated Without Neoadjuvant Therapy
NOZOMU NAKAI, ANRI MAEDA, TAKESHI YANAGITA, TAKUYA SUZUKI, YUZO MAEDA, TAKAHISA HIROKAWA, KAZUYOSHI SHIGA, MASAYASU HARA, HIROKI TAKAHASHI, RYO OGAWA, YOICHI MATSUO, SHUJI TAKIGUCHI
Anticancer Research May 2023, 43 (5) 2333-2341; DOI: 10.21873/anticanres.16398

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Elevated Preoperative Serum Vascular Endothelial Growth Factor Does Not Predict Poor Outcomes in Curatively Resected Non-metastatic Colorectal Cancer Treated Without Neoadjuvant Therapy
NOZOMU NAKAI, ANRI MAEDA, TAKESHI YANAGITA, TAKUYA SUZUKI, YUZO MAEDA, TAKAHISA HIROKAWA, KAZUYOSHI SHIGA, MASAYASU HARA, HIROKI TAKAHASHI, RYO OGAWA, YOICHI MATSUO, SHUJI TAKIGUCHI
Anticancer Research May 2023, 43 (5) 2333-2341; DOI: 10.21873/anticanres.16398
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Keywords

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