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Research ArticleClinical Studies

In Vivo Dosimetry in the Urethra During Prostate Carbon Ion Radiotherapy

SHINNOSUKE MATSUMOTO, NARUHIRO MATSUFUJI, YUSUKE KOBA and HIROSHI TSUJI
Anticancer Research May 2023, 43 (5) 2259-2264; DOI: https://doi.org/10.21873/anticanres.16389
SHINNOSUKE MATSUMOTO
1Department of Accelerator and Medical Physics, Institute for Quantum Medical Science, Quantum Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan;
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  • For correspondence: matsumoto.shinnosuke@tmu.ac.jp
NARUHIRO MATSUFUJI
1Department of Accelerator and Medical Physics, Institute for Quantum Medical Science, Quantum Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan;
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YUSUKE KOBA
2Department of Radiation Regulatory Science Research, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan;
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HIROSHI TSUJI
3QST-Hospital, Institute for Quantum Medical Science, Quantum Medical Science Directorate, National Institutes for Quantum Science and Technology, Chiba, Japan
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Abstract

Background/Aim: In vivo dosimetry can prevent dose delivery errors by directly measuring the dose of radiation administered to a patient. However, a method for in vivo dosimetry during carbon ion radiotherapy (CIRT) has not been established. Therefore, we investigated data from in vivo dosimetry of the urethra during CIRT for prostate cancer using small spherical diode dosimeters (SSDDs). Patients and Methods: This study included five patients enrolled in a clinical trial (jRCT identifier: jRCTs032190180) on which the use of four-fraction CIRT for prostate cancer was examined. The urethral dose during CIRT for prostate cancer was measured using the SSDDs inserted into the ureteral catheter. The relative error between the in vivo and calculated doses obtained using the Xio-N treatment planning system was determined. Additionally, a dose–response stability test for the in vivo dosimeter was performed under clinical conditions. Results: The relative error between the in vivo and calculated urethral doses ranged from 6 to 12%. The dose–response stability under clinical conditions of the measured dose was ≤1%. Therefore, an error >1% would be due to an interfractional patient setup error in the large dose gradient in the urethra. Conclusion: The usefulness of in vivo dosimetry using SSDDs in CIRT and SSDDs’ potential for detecting dose delivery errors during CIRT is herein highlighted.

Key Words:
  • Radiation dosimeters
  • prostate cancer
  • urinary catheters
  • in vivo dosimetry
  • Received December 17, 2022.
  • Revision received February 23, 2023.
  • Accepted March 1, 2023.
  • Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 43 (5)
Anticancer Research
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May 2023
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In Vivo Dosimetry in the Urethra During Prostate Carbon Ion Radiotherapy
SHINNOSUKE MATSUMOTO, NARUHIRO MATSUFUJI, YUSUKE KOBA, HIROSHI TSUJI
Anticancer Research May 2023, 43 (5) 2259-2264; DOI: 10.21873/anticanres.16389

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In Vivo Dosimetry in the Urethra During Prostate Carbon Ion Radiotherapy
SHINNOSUKE MATSUMOTO, NARUHIRO MATSUFUJI, YUSUKE KOBA, HIROSHI TSUJI
Anticancer Research May 2023, 43 (5) 2259-2264; DOI: 10.21873/anticanres.16389
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Keywords

  • Radiation dosimeters
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