Research ArticleClinical Studies

Helical Tomotherapy of Lymph Node-negative Early-stage Breast Cancer After Breast-conserving Surgery: Long-term Results

FELIX ZWICKER, RUDOLF KLEPPER, HENRIK HAUSWALD, SEBASTIAN HOEFEL, LUIS RAETHER, PETER E. HUBER, JUERGEN DEBUS and MICHAEL SCHEMPP
Anticancer Research May 2023, 43 (5) 2041-2053; DOI: https://doi.org/10.21873/anticanres.16365

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Figures

  • Figure 1.
    Figure 1.

    An example of the dose distribution in adjuvant radiotherapy (whole breast with integrated boost of the tumour bed; 50.4/64.4Gy in 28 fractions) of a female patient with right-sided lymph node negative early breast cancer after breast-conserving surgery using helical tomotherapy is shown. In the computer-tomography slice, the planning target volume (PTV) of the whole left breast is marked with red outlines and of the boost volume/tumour bed is marked with violet outlines. The relative isodoses of the described median PTV dose (50.4 Gy) are shown.

  • Figure 2.
    Figure 2.

    Kaplan-Meier curve for local control (LC) in all patients (n=219) (A), or according to grade (G1, G2, G3) (B), tumour stage (T1, T2) (C) and receptor expression [hormone-positive and human epidermal growth factor receptor 2 (HER2)-negative, HER2 positive (3+), and triple negative] (D).

  • Figure 3.
    Figure 3.

    Kaplan-Meier curve for metastasis free survival (MFS) in all patients (n=219) (A), or according to grade (G1, G2, G3) (B), tumour stage (T1, T2) (C) and receptor expression [hormone-positive and human epidermal growth factor receptor 2 (HER2)-negative, HER2-positive (3+), and triple negative] (D).

  • Figure 4.
    Figure 4.

    Kaplan-Meier curve for overall survival (OS) in all patients (n=219) (A), or according to grade (G1, G2, G3) (B), tumour stage (T1, T2) (C) and to receptor expression [hormone positive and human epidermal growth factor receptor 2 (HER2)-negative, HER2-positive (3+), and triple negative] (D).

  • Figure 5.
    Figure 5.

    Kaplan-Meier curve for tumour specific survival (TSS) in all patients (n=219) (A), or according to grade (G1, G2, G3) (B), tumour stage (T1, T2) (C) and to receptor expression [hormone positive and human epidermal growth factor receptor 2 (HER2) negative, HER2-positive (3+), and triple negative] (D).

  • Figure 6.
    Figure 6.

    Kaplan-Meier curve for secondary malignoma free survival (SMFS) regarding all patients (n=219).

Tables

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Helical Tomotherapy of Lymph Node-negative Early-stage Breast Cancer After Breast-conserving Surgery: Long-term Results
FELIX ZWICKER, RUDOLF KLEPPER, HENRIK HAUSWALD, SEBASTIAN HOEFEL, LUIS RAETHER, PETER E. HUBER, JUERGEN DEBUS, MICHAEL SCHEMPP
Anticancer Research May 2023, 43 (5) 2041-2053; DOI: 10.21873/anticanres.16365
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