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Research ArticleExperimental Studies

TU-100 Antagonizes the M2 Polarization Phenotype of Macrophages in the Tumor Microenvironment by Suppressing the TLR4/NF-GraphicB/STAT3 Axis

SHUHAI CHEN, YUJI MORINE, YU SAITO, SHINICHIRO YAMADA, HIROKI TERAOKU, TETSUYA IKEMOTO and MITSUO SHIMADA
Anticancer Research May 2023, 43 (5) 1985-1992; DOI: https://doi.org/10.21873/anticanres.16359
SHUHAI CHEN
Department of Surgery, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan
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YUJI MORINE
Department of Surgery, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan
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  • For correspondence: ymorine@tokushima-u.ac.jp
YU SAITO
Department of Surgery, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan
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SHINICHIRO YAMADA
Department of Surgery, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan
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HIROKI TERAOKU
Department of Surgery, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan
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TETSUYA IKEMOTO
Department of Surgery, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan
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MITSUO SHIMADA
Department of Surgery, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan
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Article Information

vol. 43 no. 5 1985-1992
DOI 
https://doi.org/10.21873/anticanres.16359
PubMed 
37097685

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received March 13, 2023
  • Revision received March 23, 2023
  • Accepted March 24, 2023
  • Published online April 25, 2023.

Copyright & Usage 
Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. SHUHAI CHEN,
  2. YUJI MORINE⇑,
  3. YU SAITO,
  4. SHINICHIRO YAMADA,
  5. HIROKI TERAOKU,
  6. TETSUYA IKEMOTO and
  7. MITSUO SHIMADA
  1. Department of Surgery, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan
  1. Correspondence to: Dr. Yuji Morine, Department of Surgery, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. Tel: +81 886339276, Fax: +81 886319698, e-mail: ymorine{at}tokushima-u.ac.jp.
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Anticancer Research: 43 (5)
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TU-100 Antagonizes the M2 Polarization Phenotype of Macrophages in the Tumor Microenvironment by Suppressing the TLR4/NF-GraphicB/STAT3 Axis
SHUHAI CHEN, YUJI MORINE, YU SAITO, SHINICHIRO YAMADA, HIROKI TERAOKU, TETSUYA IKEMOTO, MITSUO SHIMADA
Anticancer Research May 2023, 43 (5) 1985-1992; DOI: 10.21873/anticanres.16359

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TU-100 Antagonizes the M2 Polarization Phenotype of Macrophages in the Tumor Microenvironment by Suppressing the TLR4/NF-GraphicB/STAT3 Axis
SHUHAI CHEN, YUJI MORINE, YU SAITO, SHINICHIRO YAMADA, HIROKI TERAOKU, TETSUYA IKEMOTO, MITSUO SHIMADA
Anticancer Research May 2023, 43 (5) 1985-1992; DOI: 10.21873/anticanres.16359
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Keywords

  • tumor-associated macrophages
  • M2 polarization
  • tumor microenvironment
  • toll-like receptor 4
  • nuclear factor-B
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