Pharmacokinetics and Pharmacodynamics of Glucarpidase Rescue Treatment After High-dose Methotrexate Therapy Based on Modeling and Simulation

TOSHIMI KIMURA; YUTAKA FUKAYA; YUKIHIRO HAMADA; KENICHI YOSHIMURA; HIROSHI KAWAMOTO

doi:10.21873/anticanres.16351

Article Information

vol. 43 no. 5 1919-1924

DOI

https://doi.org/10.21873/anticanres.16351

PMID

37097666

Published By

International Institute of Anticancer Research

Print ISSN

0250-7005

Online ISSN

1791-7530

History

Received February 27, 2023
Revision received March 12, 2023
Accepted March 15, 2023
Published online April 25, 2023.

Copyright © 2023 The Author(s). Published by the International Institute of Anticancer Research. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).

Author Information

TOSHIMI KIMURA¹,
YUTAKA FUKAYA² ⇑,
YUKIHIRO HAMADA²,
KENICHI YOSHIMURA³ and
HIROSHI KAWAMOTO⁴

¹Department of Pharmacy, Juntendo University Hospital, Tokyo, Japan;
²Department of Pharmacy, Tokyo Women’s Medical University Hospital, Tokyo, Japan;
³Center for Integrated Medical Research, Hiroshima University Hospital, Hiroshima, Japan;
⁴Department of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan

Correspondence to: Yutaka Fukaya, Department of Pharmacy, Tokyo Women’s Medical University Hospital, 8-1 Kawada-cho, Shinjyuku-ku, Tokyo 162-8666, Japan. Tel.: +81 333538111, Fax: +81 352697385, e-mail: fukaya.yutaka{at}twmu.ac.jp

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