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Research ArticleClinical Studies

Pelvic Neoadjuvant Radiotherapy for Stage M1a Rectal Adenocarcinoma Patients Treated With Systemic Therapy Followed by Proctectomy and Metastasectomy: A Nationwide Retrospective Cohort Study

TAO-WEI KE, SHENG-CHI CHANG, HUNG-CHANG CHEN, HWEI-MING WANG, WILLIAM TZU-LIANG CHEN, YI-CHANG CHEN, MING-HAO HSIEH, YUAN-YAO TSAI, CHENG-WEI HUANG, YU-MIN LIAO, CHE-HUNG LIN, CHUN-LIN HUANG, LIANG-CHI CHEN and CHUN-RU CHIEN
Anticancer Research April 2023, 43 (4) 1843-1851; DOI: https://doi.org/10.21873/anticanres.16338
TAO-WEI KE
1Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
2School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan, R.O.C.;
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SHENG-CHI CHANG
1Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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HUNG-CHANG CHEN
1Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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HWEI-MING WANG
1Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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WILLIAM TZU-LIANG CHEN
1Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
3Department of Surgery, China Medical University Hsinchu Hospital, Hsinchu, Taiwan, R.O.C.;
4School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.;
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YI-CHANG CHEN
1Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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MING-HAO HSIEH
1Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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YUAN-YAO TSAI
1Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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CHENG-WEI HUANG
1Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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YU-MIN LIAO
5Division of Hematology and Oncology, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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CHE-HUNG LIN
5Division of Hematology and Oncology, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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CHUN-LIN HUANG
6Department of Medical Imaging, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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LIANG-CHI CHEN
7Department of Pathology, China Medical University Hospital, Taichung, Taiwan, R.O.C.;
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CHUN-RU CHIEN
4School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan, R.O.C.;
8Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan, R.O.C.
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  • For correspondence: d16181@gmail.com
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Abstract

Background/Aim: The effect of pelvic neoadjuvant radiotherapy (nRT) for stage M1a rectal adenocarcinoma patients treated with systemic therapy followed by proctectomy and metastasectomy was scarcely investigated in the literatures. Patients and Methods: The eligible rectal cancer patients diagnosed between 2011-2019 were identified via the Taiwan Cancer Registry. In the primary analysis, we used propensity score weighting to balance observable potential confounders and compared the hazard ratio (HR) of death for the nRT group vs. without RT group. We also compared the incidence of rectal cancer mortality (IRCM) and performed various supplementary analyses. Results: Our primary analyses included 145 patients. nRT was associated with improved OS (HR=0.51, p=0.01). The numerical trends remained similar for IRCM and in supplementary analyses. Conclusion: nRT was associated with improved OS in our study population.

Key Words:
  • Pelvic neoadjuvant radiotherapy
  • rectal adenocarcinoma
  • systemic therapy
  • Received January 30, 2023.
  • Revision received February 13, 2023.
  • Accepted February 16, 2023.
  • Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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Anticancer Research: 43 (4)
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April 2023
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Pelvic Neoadjuvant Radiotherapy for Stage M1a Rectal Adenocarcinoma Patients Treated With Systemic Therapy Followed by Proctectomy and Metastasectomy: A Nationwide Retrospective Cohort Study
TAO-WEI KE, SHENG-CHI CHANG, HUNG-CHANG CHEN, HWEI-MING WANG, WILLIAM TZU-LIANG CHEN, YI-CHANG CHEN, MING-HAO HSIEH, YUAN-YAO TSAI, CHENG-WEI HUANG, YU-MIN LIAO, CHE-HUNG LIN, CHUN-LIN HUANG, LIANG-CHI CHEN, CHUN-RU CHIEN
Anticancer Research Apr 2023, 43 (4) 1843-1851; DOI: 10.21873/anticanres.16338

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Pelvic Neoadjuvant Radiotherapy for Stage M1a Rectal Adenocarcinoma Patients Treated With Systemic Therapy Followed by Proctectomy and Metastasectomy: A Nationwide Retrospective Cohort Study
TAO-WEI KE, SHENG-CHI CHANG, HUNG-CHANG CHEN, HWEI-MING WANG, WILLIAM TZU-LIANG CHEN, YI-CHANG CHEN, MING-HAO HSIEH, YUAN-YAO TSAI, CHENG-WEI HUANG, YU-MIN LIAO, CHE-HUNG LIN, CHUN-LIN HUANG, LIANG-CHI CHEN, CHUN-RU CHIEN
Anticancer Research Apr 2023, 43 (4) 1843-1851; DOI: 10.21873/anticanres.16338
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Keywords

  • Pelvic neoadjuvant radiotherapy
  • rectal adenocarcinoma
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