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Research ArticleExperimental Studies

SOX10 Inhibits T Cell Recognition by Inducing Expression of the Immune Checkpoint Molecule PD-L1 in A375 Melanoma Cells

KENTA SASAKI, YOSHIHIKO HIROHASHI, KENJI MURATA, TOMOYUKI MINOWA, MUNEHIDE NAKATSUGAWA, AIKO MURAI, YUKA MIZUE, TERUFUMI KUBO, TAKAYUKI KANASEKI, TOMOHIDE TSUKAHARA, SADAHIRO IWABUCHI, SHINICHI HASHIMOTO, HISASHI UHARA, AKEMI ISHIDA-YAMAMOTO and TOSHIHIKO TORIGOE
Anticancer Research April 2023, 43 (4) 1477-1484; DOI: https://doi.org/10.21873/anticanres.16296
KENTA SASAKI
1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;
2Department of Dermatology, Asahikawa Medical University School of Medicine, Hokkaido, Japan;
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YOSHIHIKO HIROHASHI
1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;
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  • For correspondence: hirohash{at}sapmed.ac.jp
KENJI MURATA
1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;
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TOMOYUKI MINOWA
1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;
3Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan;
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MUNEHIDE NAKATSUGAWA
4Department of Pathology, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan;
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AIKO MURAI
1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;
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YUKA MIZUE
1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;
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TERUFUMI KUBO
1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;
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TAKAYUKI KANASEKI
1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;
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TOMOHIDE TSUKAHARA
1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;
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SADAHIRO IWABUCHI
5Department of Molecular Pathophysiology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan
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SHINICHI HASHIMOTO
5Department of Molecular Pathophysiology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan
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HISASHI UHARA
3Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan;
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AKEMI ISHIDA-YAMAMOTO
2Department of Dermatology, Asahikawa Medical University School of Medicine, Hokkaido, Japan;
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TOSHIHIKO TORIGOE
1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;
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  • For correspondence: torigoe{at}sapmed.ac.jp
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Article Information

vol. 43 no. 4 1477-1484
DOI 
https://doi.org/10.21873/anticanres.16296
PMID 
36974807

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received December 29, 2022
  • Revision received January 5, 2023
  • Accepted January 23, 2023
  • Published online March 27, 2023.

Copyright & Usage 
Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. KENTA SASAKI1,2,
  2. YOSHIHIKO HIROHASHI1⇑,
  3. KENJI MURATA1,
  4. TOMOYUKI MINOWA1,3,
  5. MUNEHIDE NAKATSUGAWA4,
  6. AIKO MURAI1,
  7. YUKA MIZUE1,
  8. TERUFUMI KUBO1,
  9. TAKAYUKI KANASEKI1,
  10. TOMOHIDE TSUKAHARA1,
  11. SADAHIRO IWABUCHI5,
  12. SHINICHI HASHIMOTO5,
  13. HISASHI UHARA3,
  14. AKEMI ISHIDA-YAMAMOTO2 and
  15. TOSHIHIKO TORIGOE1⇑
  1. 1Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan;
  2. 2Department of Dermatology, Asahikawa Medical University School of Medicine, Hokkaido, Japan;
  3. 3Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan;
  4. 4Department of Pathology, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan;
  5. 5Department of Molecular Pathophysiology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan
  1. Correspondence to: Yoshihiko Hirohashi and Toshihiko Torigoe, Department of Pathology, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-Ku, Sapporo, Hokkaido 060-8556, Japan. Tel: +81 116112111 (ext. 26920), Fax: +81 116432310, e-mail: hirohash{at}sapmed.ac.jp (YH)
  2. Correspondence to: Toshihiko Torigoe, Department of Pathology, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-Ku, Sapporo, Hokkaido 060-8556, Japan. Tel: +81 116112111 (ext. 26920), Fax: +81 116432310, torigoe{at}sapmed.ac.jp (TT)
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Anticancer Research: 43 (4)
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SOX10 Inhibits T Cell Recognition by Inducing Expression of the Immune Checkpoint Molecule PD-L1 in A375 Melanoma Cells
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SOX10 Inhibits T Cell Recognition by Inducing Expression of the Immune Checkpoint Molecule PD-L1 in A375 Melanoma Cells
KENTA SASAKI, YOSHIHIKO HIROHASHI, KENJI MURATA, TOMOYUKI MINOWA, MUNEHIDE NAKATSUGAWA, AIKO MURAI, YUKA MIZUE, TERUFUMI KUBO, TAKAYUKI KANASEKI, TOMOHIDE TSUKAHARA, SADAHIRO IWABUCHI, SHINICHI HASHIMOTO, HISASHI UHARA, AKEMI ISHIDA-YAMAMOTO, TOSHIHIKO TORIGOE
Anticancer Research Apr 2023, 43 (4) 1477-1484; DOI: 10.21873/anticanres.16296

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SOX10 Inhibits T Cell Recognition by Inducing Expression of the Immune Checkpoint Molecule PD-L1 in A375 Melanoma Cells
KENTA SASAKI, YOSHIHIKO HIROHASHI, KENJI MURATA, TOMOYUKI MINOWA, MUNEHIDE NAKATSUGAWA, AIKO MURAI, YUKA MIZUE, TERUFUMI KUBO, TAKAYUKI KANASEKI, TOMOHIDE TSUKAHARA, SADAHIRO IWABUCHI, SHINICHI HASHIMOTO, HISASHI UHARA, AKEMI ISHIDA-YAMAMOTO, TOSHIHIKO TORIGOE
Anticancer Research Apr 2023, 43 (4) 1477-1484; DOI: 10.21873/anticanres.16296
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