Table of Contents

Clinical Studies

• Open Access

  EZH2 Expression Correlates With T-Cell Infiltration in Oral Leukoplakia and Predicts Cancer Transformation

  DIVYA GANESH, AMAL DAFAR, JULIA NIKLASSON, INGRID SANDBERG, PAULO BRAZ-SILVA, DIPAK SAPKOTA, JENNY ÖHMAN, DANIEL GIGLIO and BENGT HASSÉUS

  Anticancer Research April 2023, 43 (4) 1533-1542; DOI: https://doi.org/10.21873/anticanres.16302
• Open Access

  Gastric Linitis Plastica: Clinical Characteristics and Outcomes from the National Cancer Database

  ADIL AYUB, BURIA NAEEM, ALEXANDER PEREZ, DOUGLAS TYLER and V. SUZANNE KLIMBERG

  Anticancer Research April 2023, 43 (4) 1543-1548; DOI: https://doi.org/10.21873/anticanres.16303
• Open Access

  Outcome of Multidisciplinary Treatment of Merkel Cell Carcinoma of the Hand and Wrist

  SAMUEL E. BROIDA, KAREME D. ALDER, XIAO T. CHEN, STEVEN L. MORAN and MATTHEW T. HOUDEK

  Anticancer Research April 2023, 43 (4) 1549-1553; DOI: https://doi.org/10.21873/anticanres.16304
• Open Access

  Surgical Treatments for Ductal Carcinoma In Situ (DCIS) in Elderly Patients

  ORESTE CLAUDIO BUONOMO, MARCO PELLICCIARO, MARCO MATERAZZO, SIMONE BERARDI, PAOLA ELDA GIGLIOTTI, JONATHAN CASPI, ROSARIA MEUCCI, TOMMASO PERRETTA, ILARIA PORTARENA, MARIO DAURI, CHIARA ADRIANA PISTOLESE and GIANLUCA VANNI

  Anticancer Research April 2023, 43 (4) 1555-1562; DOI: https://doi.org/10.21873/anticanres.16305
• Open Access

  Prognostic Value of KRAS Exon-specific Mutations in Patients With Colorectal Cancer

  KENTARO ASAKO, TAMURO HAYAMA, YOJIRO HASHIGUCHI, TOSHIYA MIYATA, YOSHIHISA FUKUSHIMA, RYU SHIMADA, KENSUKE KANEKO, KEIJIRO NOZAWA, KEIJI MATSUDA and TAKEO FUKAGAWA

  Anticancer Research April 2023, 43 (4) 1563-1568; DOI: https://doi.org/10.21873/anticanres.16306
• Open Access

  Diagnostic Accuracy of Fecal Immunochemical Test (FIT) in Bleed-positive and Bleed-negative Colorectal Cancer (CRC) Among a Cohort of 5,090 Subjects who Participated in the Colorectal Neoplasia (CRN) Screening in Brazil

  MAARET ESKELINEN, JANNICA MEKLIN, DENISE PEIXOTO GUIMARAES, TUOMAS SELANDER, KARI SYRJÄNEN and MATTI ESKELINEN

  Anticancer Research April 2023, 43 (4) 1569-1580; DOI: https://doi.org/10.21873/anticanres.16307
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  Biphenotypic Sinonasal Sarcoma: Case Reports of Diagnostic Findings and Clinical Management of 3 Cases

  YOLANDA AUGUSTIN, SHANE ZAIDI, ROBIN L. JONES, CHARLOTTE BENSON, RICHARD SIMCOCK, CYRIL FISHER, KHIN THWAY, MAGNUS HALLIN and AISHA B. MIAH

  Anticancer Research April 2023, 43 (4) 1581-1589; DOI: https://doi.org/10.21873/anticanres.16308
• Open Access

  Visualization of Anorectal Lymphatic Flow Using Indocyanine Green Fluorescence Imaging: An Observational Study

  KENTARO SATO, HIROYUKI KASAJIMA, KEN IMAIZUMI, MICHIHIRO KURUSHIMA, MINORU UMEHARA, YOSUKE TSURUGA, DAISUKE YAMANA, AYA SATO, KENTARO ICHIMURA, TAKUMU FUKASAWA, KEIICHIRO ITO, MARINA ISOKAWA and KAZUAKI NAKANISHI

  Anticancer Research April 2023, 43 (4) 1591-1598; DOI: https://doi.org/10.21873/anticanres.16309
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  Identification of Atezolizumab Plus Bevacizumab Prognostic Index via Recursive Partitioning Analysis in HCC: The ABE Index

  MARA PERSANO, MARGHERITA RIMINI, TOSHIFUMI TADA, GOKI SUDA, SHIGEO SHIMOSE, MASATOSHI KUDO, JAEKYUNG CHEON, FABIAN FINKELMEIER, HO YEONG LIM, JOSÉ PRESA, GIANLUCA MASI, CHANGHOON YOO, SARA LONARDI, TIZIANA PRESSIANI, FABIO PISCAGLIA, TAKASHI KUMADA, LORENZA RIMASSA, MARIO SCARTOZZI, STEFANO CASCINU, ANDREA CASADEI-GARDINI and HCC COLLABORATIVE GROUP

  Anticancer Research April 2023, 43 (4) 1599-1610; DOI: https://doi.org/10.21873/anticanres.16310
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  Comparison of Quality of Life and Injection Site Reactions After Switching from Degarelix 80 mg to 480 mg in Advanced Prostate Cancer: A Prospective Trial

  KEIICHIRO MIYAJIMA, TAKAFUMI YANAGISAWA, HIROTAKA SUZUKI, WATARU FUKUOKAYA, KEIGO SAKANAKA, KOKI OBAYASHI, JUN MIKI and TAKAHIRO KIMURA

  Anticancer Research April 2023, 43 (4) 1611-1621; DOI: https://doi.org/10.21873/anticanres.16311
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  The Japanese 5-5-500 Rule Predicts Prognosis of Hepatocellular Carcinoma After Hepatic Resection

  TERUYUKI TAKISHIMA, KOICHIRO HARUKI, TOMOHIKO TANIAI, KENEI FURUKAWA, TAKASHI HORIUCHI, SHINJI ONDA, MITSURU YANAGAKI, YOSHIHIRO SHIRAI, RYOGA HAMURA and TORU IKEGAMI

  Anticancer Research April 2023, 43 (4) 1623-1629; DOI: https://doi.org/10.21873/anticanres.16312
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  Elevation of the Neutrophil-to-Lymphocyte Ratio Is a Significant Postoperative Poor Prognostic Factor in Patients With Clinical T3-4 Centrally Located Primary Lung Cancer

  TAKUMA TSUKIOKA, NOBUHIRO IZUMI, HIROAKI KOMATSU, HIDETOSHI INOUE, RYUICHI ITO, SATOSHI SUZUKI and NORITOSHI NISHIYAMA

  Anticancer Research April 2023, 43 (4) 1631-1636; DOI: https://doi.org/10.21873/anticanres.16313
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  Optimization of Fluence Map for CyberKnife Raster Scanning Intensity Modulated Radiotherapy

  YUICHI AKINO, HIROYA SHIOMI, NOBUHISA MABUCHI, NORIHISA MASAI, RYOONG-JIN OH and KAZUHIKO OGAWA

  Anticancer Research April 2023, 43 (4) 1637-1642; DOI: https://doi.org/10.21873/anticanres.16314
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  Positive p16 Immunostaining Is an Independent Prognostic Variable for Disease-free Survival and Overall Survival in Patients With Squamous Cell Carcinoma of the Vulva Treated With Radical Surgery and Inguinofemoral Lymphadenectomy: An Italian Single Center Retrospective Study

  ANGIOLO GADDUCCI, ENRICO SIMONETTI, STEFANIA COSIO, ANTONIO FANUCCHI, VALENTINA DOLCI, CONCETTA LALISCIA, ANTONIO GIUSEPPE NACCARATO and SABINA PISTOLESI

  Anticancer Research April 2023, 43 (4) 1643-1648; DOI: https://doi.org/10.21873/anticanres.16315
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  Evaluation of the M371-Test Under Real-life Conditions for Diagnosis and Follow Up of Testicular Germ Cell Tumors

  STEFAN PYCHA, CAROLINA D’ELIA, CHRISTINE MIAN, CHRISTINE SCHWIENBACHER, ESTHER HANSPETER, MARGHERITA PALERMO, ARMIN PYCHA, HANSJÖRG DANUSER and EMANUELA TRENTI

  Anticancer Research April 2023, 43 (4) 1649-1653; DOI: https://doi.org/10.21873/anticanres.16316
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  Complete Response to Immune Checkpoint Inhibition in a Platinum Resistant Primary Ovarian Cancer Patient With Lynch Syndrome: A Case Report and Review of the Literature

  LUKAS CHINCZEWSKI, FELIX WILHELM FELDHAUS, WOLFGANG SCHMITT, IOANA BRAICU, EVA ROSER and JALID SEHOULI

  Anticancer Research April 2023, 43 (4) 1655-1662; DOI: https://doi.org/10.21873/anticanres.16317
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  Malnutrition in Head and Neck Cancer: A Patient-reported Outcome Study

  ANDREAS COFRÉ, STEFANIE WALTER, JENS BUENTZEL and JUTTA HÜBNER

  Anticancer Research April 2023, 43 (4) 1663-1673; DOI: https://doi.org/10.21873/anticanres.16318
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  Serum Thymidine Kinase 1 – Potential Prostate Cancer Biomarker: A Clinical Study

  JAKUB REZAC, LENKA HANOUSKOVA, STEPAN VESELY, KAREL KOTASKA, ALZBETA KANTOROVA, ANNA LINHARTOVA, VOJTECH FIALA, VIKTOR SOUKUP and OTAKAR CAPOUN

  Anticancer Research April 2023, 43 (4) 1675-1680; DOI: https://doi.org/10.21873/anticanres.16319
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  Real-world Data Study of the Efficacy and Toxicity of Nivolumab vs. Cetuximab and Predictors of Response to Nivolumab in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck in a European Population

  LOLA MACIA-RIVAS, CLARA LUZ FERNANDEZ-LAGUNA, CRISTINA ALVAREZ-ASTEINZA, IVAN MARAY, MONICA CARBAJALES-ALVAREZ and ANA LOZANO-BLAZQUEZ

  Anticancer Research April 2023, 43 (4) 1681-1688; DOI: https://doi.org/10.21873/anticanres.16320
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  Clinical Significance of Neutrophil-to-Lymphocyte Ratio/Serum Albumin Ratio in Patients With Metastatic Gastric or Gastroesophageal Junction Cancer Administered Trifluridine/Tipiracil

  ITARU HASHIMOTO, KAZUKI KANO, SHIZUNE ONUMA, HIDEAKI SUEMATSU, SHINSUKE NAGASAWA, KYOHEI KANEMATSU, KYOKO FURUSAWA, TOMOMI HAMAGUCHI, MAMORU WATANABE, KEI HAYASHI, MITSUHIRO FURUTA, YASUHIRO INOKUCHI, NOZOMU MACHIDA, TORU AOYAMA, TAKANOBU YAMADA, YASUSHI RINO, TAKASHI OGATA and TAKASHI OSHIMA

  Anticancer Research April 2023, 43 (4) 1689-1697; DOI: https://doi.org/10.21873/anticanres.16321
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  Feasibility of Computed Tomography-guided Percutaneous Renal Cryoablation Under Local Anesthesia: A Single Center Experience in Taiwan

  YEN-TING LIN, SIU-WAN HUNG, MING-CHENG LIU, KUN-YUAN CHIU, JYH-WEN CHAI and JIN-CHING LIN

  Anticancer Research April 2023, 43 (4) 1699-1708; DOI: https://doi.org/10.21873/anticanres.16322
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  Significance of MYB and NTRK Expression in Head and Neck Adenoid Cystic Carcinoma

  THEODOROS PANTAZOPOULOS, DANAI LEVENTAKOU, NEKTARIOS KOUFOPOULOS, ABRAHAM POULIAKIS, PANAGIOTA ECONOMOPOULOU, CHRYSSOULA GLAVA, MARIA TZARDI, GEORGIA KAFIRI, CHRISTOS KITTAS, PENELOPE KORKOLOPOULOU, PETROULA ARAPANTONI-DADIOTI, HELEN SOTIRIOU, THEODOROS FILIPPIDIS, PAVLOS MARAGOUDAKIS, IOANNIS GIOTAKIS, IOANNIS G. PANAYIOTIDES, AMANDA PSYRRI and ALEXANDROS DELIDES

  Anticancer Research April 2023, 43 (4) 1709-1717; DOI: https://doi.org/10.21873/anticanres.16323
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  Surgical Outcomes After Pulmonary Resection With Typical or Atypical Bronchoplasty in Patients With Primary Lung Cancer

  TAKUMA TSUKIOKA, NOBUHIRO IZUMI, HIROAKI KOMATSU, HIDETOSHI INOUE, RYUICHI ITO, SATOSHI SUZUKI and NORITOSHI NISHIYAMA

  Anticancer Research April 2023, 43 (4) 1719-1724; DOI: https://doi.org/10.21873/anticanres.16324
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  Effect of Adjuvant Systemic Chemotherapy on Intravesical Recurrence After Radical Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

  NORIYA YAMAGUCHI, SHUICHI MORIZANE, TETSUYA YUMIOKA, RYUTARO SHIMIZU, SHOGO TERAOKA, HIDETO IWAMOTO, KATSUYA HIKITA, MASASHI HONDA and ATSUSHI TAKENAKA

  Anticancer Research April 2023, 43 (4) 1725-1730; DOI: https://doi.org/10.21873/anticanres.16325
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  TP53 Signature Score Predicts Prognosis and Immune Response in Triple-negative Breast Cancer

  MAI ONISHI, SHIGEO YAMAGUCHI, XUAN WEN, MIN HAN, HIDENORI KIDO, TOMOYUKI ARUGA, SHIN-ICHIRO HORIGUCHI and SHUNSUKE KATO

  Anticancer Research April 2023, 43 (4) 1731-1739; DOI: https://doi.org/10.21873/anticanres.16326
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  Incidence and Risk of Venous Thromboembolism in Patients With Resectable Pancreatic Cancer Receiving Neoadjuvant Chemotherapy

  MARIKO KAMIYA, SHINNOSUKE KAWAHARA, YUTO KAMIOKA, MASAAKI MURAKAWA, TORU AOYAMA, SATOSHI KOBAYASHI, MAKOTO UENO, NAOTO YAMAMOTO, TAKASHI OSHIMA, NORIO YUKAWA, YASUSHI RINO, MUNETAKA MASUDA and SOICHIRO MORINAGA

  Anticancer Research April 2023, 43 (4) 1741-1747; DOI: https://doi.org/10.21873/anticanres.16327
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  Prognostic Value of Radiomics Analysis of Skeletal Muscle After Radical Irradiation of Esophageal Cancer

  KAZUMA IWASHITA, HIKARU KUBOTA, RIKU NISHIOKA, YUKI EMOTO, DAISUKE KAWAHARA, TAKEAKI ISHIHARA, DAISUKE MIYAWAKI, IKUNO NISHIBUCHI, YASUSHI NAGATA and RYOHEI SASAKI

  Anticancer Research April 2023, 43 (4) 1749-1760; DOI: https://doi.org/10.21873/anticanres.16328
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  A Multidisciplinary Treatment Strategy With Conversion Surgery for Hepatocellular Carcinoma

  HIRONORI SHIOZAKI, KENEI FURUKAWA, KOICHIRO HARUKI, MICHINORI MATSUMOTO, TADASHI UWAGAWA, SHINJI ONDA, YUTO YAMAHATA, SHUNTA ISHIZAKI, KYOHEI ABE, SHUICHI FUJIOKA, YUICHI NAKASEKO, TOMOYOSHI OKAMOTO and TORU IKEGAMI

  Anticancer Research April 2023, 43 (4) 1761-1766; DOI: https://doi.org/10.21873/anticanres.16329
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  Predictors of Postoperative Gain in Ambulatory Function After Decompressive Surgery for Metastatic Spinal Cord Compression

  HIDEYUKI KINOSHITA, HIROTO KAMODA, YOKO HAGIWARA, SEIKO KINOSHITA, SEIJI OHTORI and TSUKASA YONEMOTO

  Anticancer Research April 2023, 43 (4) 1767-1773; DOI: https://doi.org/10.21873/anticanres.16330
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  Association of STAT3, CYP3A5, and ABCG2 Polymorphisms With Osimertinib-induced Adverse Events in NSCLC Patients

  MASAAKI TANDA, KAZUHIRO YAMAMOTO, TOMOKI HORI, HIROKI NISHIGUCHI, MIKI YAGI, MICHIKO SHIMIZU, TORU KONISHI, TOMONORI OZAKI, NATSUE YOSHIOKA, MOTOKO TACHIHARA, TAKEFUMI ITO, SHIGEKI IKUSHIMA, TOMOHIRO OMURA and IKUKO YANO

  Anticancer Research April 2023, 43 (4) 1775-1783; DOI: https://doi.org/10.21873/anticanres.16331
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  Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comparison Between Mismatch Repair Protein Immunostaining and Microsatellite Instability Testing

  HYUNJIN KIM and HYUN-SOO KIM

  Anticancer Research April 2023, 43 (4) 1785-1795; DOI: https://doi.org/10.21873/anticanres.16332
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  Effect of Interstitial Lung Abnormality on Concurrent Chemoradiotherapy-treated Stage III Non-small Cell Lung Cancer Patients

  WON GI JEONG, YUN-HYEON KIM, SUNG-JA AHN, JAE-UK JEONG, BYUNG CHAN LEE, ICK JOON CHO and YONG-HYUB KIM

  Anticancer Research April 2023, 43 (4) 1797-1807; DOI: https://doi.org/10.21873/anticanres.16333
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  Complete Cycles of Radium-223 Improve Overall Survival in Patients With Metastatic Castration-resistant Prostate Cancer: A Retrospective Study

  HAN-CHUNG YANG, LI-WEN CHANG, JIAN-RI LI, SHIAN-SHIANG WANG, CHENG-KUANG YANG, CHUAN-SHU CHEN, KEVIN LU, CHENG-CHE CHEN, SHU-CHI WANG, CHIA-YEN LIN, CHEN-LI CHENG, YEN-CHUAN OU, KUN-YUAN CHIU and SHENG-CHUN HUNG

  Anticancer Research April 2023, 43 (4) 1809-1816; DOI: https://doi.org/10.21873/anticanres.16334
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  Conversion Surgery for Unresectable Pancreatic Cancer Treated With FOLFIRINOX or Gemcitabine Plus Nab-paclitaxel

  YASUSHI IDE, TAIGA OTSUKA, MOTOTSUGU SHIMOKAWA, FUTA KOGA, YUJIRO UEDA, JUNICHI NAKAZAWA, AZUSA KOMORI, SATOSHI OTSU, SHIHO ARIMA, MASARU FUKAHORI, AKITAKA MAKIYAMA, YUDAI SHINOHARA, SHOHEI UENO, HIROKI TAGUCHI, TAKUYA HONDA, TARO SHIBUKI, KENTA NIO, NORIO URESHINO, TOSHIHIKO MIZUTA, KENJI MITSUGI and TSUYOSHI SHIRAKAWA

  Anticancer Research April 2023, 43 (4) 1817-1826; DOI: https://doi.org/10.21873/anticanres.16335
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  Impact of Anatomical Position Errors on Dose Distribution in Head and Neck Radiotherapy and Robust Image Registration Against Anatomical Changes

  KOUTA HIROTAKI, KENTO TOMIZAWA, SHUNSUKE MORIYA, MASASHI ITO and TAKEJI SAKAE

  Anticancer Research April 2023, 43 (4) 1827-1834; DOI: https://doi.org/10.21873/anticanres.16336
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  Prognostic Impact of a Novel Albumin-Platelet Index as Selection Criterion for Hepatic Resection in Intermediate Stage Hepatocellular Carcinoma

  KYOHEI YUGAWA, TAKASHI MAEDA, SHIGEYUKI NAGATA, AKIHIRO SAKAI, KENJI TAKETANI, SHOHEI YAMAGUCHI, KOZO KONISHI and KENKICHI HASHIMOTO

  Anticancer Research April 2023, 43 (4) 1835-1842; DOI: https://doi.org/10.21873/anticanres.16337
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  Pelvic Neoadjuvant Radiotherapy for Stage M1a Rectal Adenocarcinoma Patients Treated With Systemic Therapy Followed by Proctectomy and Metastasectomy: A Nationwide Retrospective Cohort Study

  TAO-WEI KE, SHENG-CHI CHANG, HUNG-CHANG CHEN, HWEI-MING WANG, WILLIAM TZU-LIANG CHEN, YI-CHANG CHEN, MING-HAO HSIEH, YUAN-YAO TSAI, CHENG-WEI HUANG, YU-MIN LIAO, CHE-HUNG LIN, CHUN-LIN HUANG, LIANG-CHI CHEN and CHUN-RU CHIEN

  Anticancer Research April 2023, 43 (4) 1843-1851; DOI: https://doi.org/10.21873/anticanres.16338
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  Life-threatening Airway Complication After Radioactive Iodine Treatment: A Case Report and Review of the Literature

  FREDRIK LANDSTRÖM, JANA SANDBERG and JOHAN REIZENSTEIN

  Anticancer Research April 2023, 43 (4) 1853-1855; DOI: https://doi.org/10.21873/anticanres.16339
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  Treatment of Mediastinal Endometrial Carcinoma Developed from Extragenital Endometriosis and Simultaneous Rectal Adenocarcinoma in a 55-year-old Woman

  KLARA DORMAN, DANMEI ZHANG, WOLFGANG G. KUNZ, MARTIN ANGELE, JENS NEUMANN, ALEXANDER BURGES, MICHAEL VON BERGWELT-BAILDON, VOLKER HEINEMANN, STEFAN BOECK and CLEMENS GIESSEN-JUNG

  Anticancer Research April 2023, 43 (4) 1857-1861; DOI: https://doi.org/10.21873/anticanres.16340
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  A Laparoscopically Treated Case of Peritoneal Dissemination Mimicking Liver Metastases from Distal Cholangiocarcinoma Four Years After the Initial Pancreaticoduodenectomy

  KENSUKE YAMAMURA, TORU BEPPU, KOICHI KINOSHITA, KAZUKI MATSUMURA, ERI ODA, YASUNORI NAGAYAMA, TOSHIHIKO MOTOHARA, HIDEAKI MIYAMOTO, FUJIO MATSUMURA, RIN YAMADA, YOSHIHIKO KOMOHARA, HIROHISA OKABE, TATSUNORI MIYATA and TAKATOSHI ISIKO

  Anticancer Research April 2023, 43 (4) 1863-1867; DOI: https://doi.org/10.21873/anticanres.16341
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  Giant Cell Angiofibroma in the Buccal Mucosa – A Rising Entity?

  FLORIAN DUDDE, FILIP BARBAREWICZ, THOMAS TELSCHOW, ADRIAN ZU KNYPHAUSEN and KAI-OLAF HENKEL

  Anticancer Research April 2023, 43 (4) 1869-1871; DOI: https://doi.org/10.21873/anticanres.16342