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Carbon Ion Radiotherapy Versus Perioperative Adjuvant Chemotherapy and Curative Surgery for Resectable Pancreatic Cancer

NAOTO YAMAMOTO, TAKASHI OSHIMA, SHINNOSUKE KAWAHARA, DAISHI TAKAHASHI, YUTO KAMIOKA, MASAAKI MURAKAWA, HIROYUKI KATOH, MAKOTO UENO and SOICHIRO MORINAGA
Anticancer Research February 2023, 43 (2) 809-815; DOI: https://doi.org/10.21873/anticanres.16222
NAOTO YAMAMOTO
1Department of Hepatobiliary and Pancreatic Surgery, Kanagawa Cancer Center, Yokohama, Japan;
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TAKASHI OSHIMA
2Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan;
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  • For correspondence: oshimat{at}kcch.jp
SHINNOSUKE KAWAHARA
1Department of Hepatobiliary and Pancreatic Surgery, Kanagawa Cancer Center, Yokohama, Japan;
3Department of Surgery, Yokohama City University, Yokohama, Japan;
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DAISHI TAKAHASHI
1Department of Hepatobiliary and Pancreatic Surgery, Kanagawa Cancer Center, Yokohama, Japan;
3Department of Surgery, Yokohama City University, Yokohama, Japan;
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YUTO KAMIOKA
1Department of Hepatobiliary and Pancreatic Surgery, Kanagawa Cancer Center, Yokohama, Japan;
3Department of Surgery, Yokohama City University, Yokohama, Japan;
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MASAAKI MURAKAWA
1Department of Hepatobiliary and Pancreatic Surgery, Kanagawa Cancer Center, Yokohama, Japan;
3Department of Surgery, Yokohama City University, Yokohama, Japan;
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HIROYUKI KATOH
4Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama, Japan;
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MAKOTO UENO
5Department of Gastroenterology, Kanagawa Cancer Center, Yokohama, Japan
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SOICHIRO MORINAGA
1Department of Hepatobiliary and Pancreatic Surgery, Kanagawa Cancer Center, Yokohama, Japan;
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    Figure 1.

    Comparison of progression-free survival (PFS) and overall survival (OS) between the carbon ion radiotherapy (CIRT) monotherapy group and the preoperative adjuvant chemotherapy (NAC) + curative surgery + adjuvant chemotherapy group before propensity score matching. (A) There is no significant difference in PFS between the CIRT monotherapy and the NAC + curative surgery + adjuvant chemotherapy group (p=0.733). (B) OS is better in the NAC + curative surgery + adjuvant chemotherapy group compared to the CIRT monotherapy group (p=0.006).

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    Figure 2.

    Comparison of progression-free survival (PFS) and overall survival (OS) between the carbon ion radiotherapy (CIRT) monotherapy group and preoperative adjuvant chemotherapy (NAC) + curative surgery + adjuvant chemotherapy group by propensity score matching. (A) There is no significant difference in PFS between the CIRT monotherapy and NAC + curative surgery + adjuvant chemotherapy groups (p=0.992). (B) OS is significantly better in the NAC + curative surgery + adjuvant chemotherapy group than in the CIRT monotherapy group (p=0.037).

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Anticancer Research: 43 (2)
Anticancer Research
Vol. 43, Issue 2
February 2023
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Carbon Ion Radiotherapy Versus Perioperative Adjuvant Chemotherapy and Curative Surgery for Resectable Pancreatic Cancer
NAOTO YAMAMOTO, TAKASHI OSHIMA, SHINNOSUKE KAWAHARA, DAISHI TAKAHASHI, YUTO KAMIOKA, MASAAKI MURAKAWA, HIROYUKI KATOH, MAKOTO UENO, SOICHIRO MORINAGA
Anticancer Research Feb 2023, 43 (2) 809-815; DOI: 10.21873/anticanres.16222

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Carbon Ion Radiotherapy Versus Perioperative Adjuvant Chemotherapy and Curative Surgery for Resectable Pancreatic Cancer
NAOTO YAMAMOTO, TAKASHI OSHIMA, SHINNOSUKE KAWAHARA, DAISHI TAKAHASHI, YUTO KAMIOKA, MASAAKI MURAKAWA, HIROYUKI KATOH, MAKOTO UENO, SOICHIRO MORINAGA
Anticancer Research Feb 2023, 43 (2) 809-815; DOI: 10.21873/anticanres.16222
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Keywords

  • pancreatic cancer
  • Carbon ion radiotherapy
  • perioperative adjuvant chemotherapy
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